| Issue |
Parasite
Volume 32, 2025
|
|
|---|---|---|
| Article Number | 42 | |
| Number of page(s) | 18 | |
| DOI | https://doi.org/10.1051/parasite/2025035 | |
| Published online | 04 July 2025 | |
Supplementary material
Supplementary Note 1: Functional characterization of differentially expressed gene families. Access here
Supplementary Table 1: Average binding free energies calculated from molecular dynamics (MD) simulations for moxidectin (MOX) and the chloride channel of Leishmania tropica. Access here
Supplementary Table 2: Top 10 upregulated and downregulated genes in L. tropica promastigotes following moxidectin (MOX) exposure, with corresponding log2 fold change values and statistical significance. Access here
Supplementary Table 3: Top 10 upregulated and downregulated genes in L. tropica intracellular amastigotes following moxidectin (MOX) exposure, with corresponding log2 fold change values and statistical significance. Access here
Supplementary Table 4: List of differentially expressed genes within the seven assembled gene sets, including ABC transporters, HSP70, cytochrome c oxidase, NADH-cytochrome b5 reductase, aquaporins, major facilitator superfamily (MFS), and chloride channels. Access here
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Supplementary Figure 1:
Differential gene expression profiles in L. tropica promastigotes and amastigotes following moxidectin (MOX) exposure. |
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Supplementary Figure 2:
Gene set enrichment analysis (GSEA) plots for ABC transporters in intracellular amastigotes of L. tropica. |
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Supplementary Figure 3:
Gene set enrichment analysis (GSEA) plots for ABC transporters in promastigotes of L. tropica. |
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Supplementary Figure 4:
Gene set enrichment analysis (GSEA) plots for aquaporins in intracellular amastigotes of L. tropica. |
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Supplementary Figure 5:
Gene set enrichment analysis (GSEA) plots for aquaporins in promastigotes of L. tropica. |
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Supplementary Figure 6:
Gene set enrichment analysis (GSEA) plots for chloride channels in intracellular amastigotes of L. tropica. |
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Supplementary Figure 7:
Gene set enrichment analysis (GSEA) plots for chloride channels in promastigotes of L. tropica. |
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Supplementary Figure 8:
Gene set enrichment analysis (GSEA) plots for cytochrome c oxidase in intracellular amastigotes of L. tropica. |
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Supplementary Figure 9:
Gene set enrichment analysis (GSEA) plots for cytochrome c oxidase in promastigotes of L. tropica. |
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Supplementary Figure 10:
Gene set enrichment analysis (GSEA) plots for HSP70 in intracellular amastigotes of L. tropica. |
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Supplementary Figure 11:
Gene set enrichment analysis (GSEA) plots for HSP70 in promastigotes of L. tropica. |
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Supplementary Figure 12:
Gene set enrichment analysis (GSEA) plots for major facilitator superfamily (MFS) proteins in intracellular amastigotes of L. tropica. |
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Supplementary Figure 13:
Gene set enrichment analysis (GSEA) plots for major facilitator superfamily (MFS) proteins in promastigotes of L. tropica. |
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Supplementary Figure 14:
Gene set enrichment analysis (GSEA) plots for NADH-cytochrome b5 reductase in intracellular amastigotes of L. tropica. |
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Supplementary Figure 15:
Gene set enrichment analysis (GSEA) plots for NADH-cytochrome b5 reductase in promastigotes of L. tropica. |
© L. Al Samra et al., published by EDP Sciences, 2025
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