Table 2
Efficacy and resistance ratios (RR) for promastigotes and intracellular amastigotes of L. tropica under increasing drug pressure.
| Generation | 1 |
5 |
10 |
15 |
||||
|---|---|---|---|---|---|---|---|---|
| Promastigotes |
||||||||
| IC50 ± SE (μM) | RR* ± SE | IC50 ± SE (μM) | RR ± SE | IC50 ± SE (μM) | RR ± SE | IC50 ± SE (μM) | RR ± SE | |
| PER | 1.72 ± 0.01 | 1.00 ± 0.00 | 4.25 ± 0.04 | 2.47 ± 0.04 | 15.58 ± 0.13 | 9.06 ± 0.12 | 34.56 ± 0.21 | 20.09ab# ± 0.24 |
| IVM | 0.70 ± 0.08 | 1.00 ± 0.00 | 1.75 ± 0.01 | 2.52 ± 0.28 | 5.17 ± 0.09 | 7.46 ± 0.81 | 13.90 ± 0.34 | 20.02ab ± 1.81 |
| MOX | 0.59 ± 0.03 | 1.00 ± 0.00 | 0.92 ± 0.01 | 1.56 ± 0.06 | 3.08 ± 0.07 | 5.24 ± 0.26 | 10.11 ± 0.08 | 17.23a ± 0.64 |
| AFO | 0.60 ± 0.02 | 1.00 ± 0.00 | 0.95 ± 0.04 | 1.59 ± 0.10 | 3.38 ± 0.03 | 5.63 ± 0.16 | 10.36 ± 0.04 | 17.28a ± 0.50 |
| ML | 1.51 ± 0.18 | 1.00 ± 0.00 | 3.52 ± 0.49 | 2.34 ± 0.22 | 13.68 ± 0.79 | 9.21 ± 1.66 | 30.83 ± 1.30 | 20.60b ± 1.72 |
| Intracellular amastigotes |
||||||||
| IC50 ± SE (μM) |
RR* ± SE |
IC50 ± SE (μM) |
RR ± SE |
IC50 ± SE (μM) |
RR ± SE |
IC50 ± SE (μM) |
RR ± SE |
|
| PER | 2.13 ± 0.08 | 1.00 ± 0.00 | 4.86 ± 0.04 | 2.29 ± 0.07 | 7.87 ± 0.08 | 3.71 ± 0.16 | 12.15 ± 0.06 | 5.72b ± 0.18 |
| IVM | 1.32 ± 0.12 | 1.00 ± 0.00 | 2.22 ± 0.09 | 1.69 ± 0.21 | 4.35 ± 0.13 | 3.31 ± 0.37 | 6.18 ± 0.05 | 4.70ab ± 0.46 |
| MOX | 0.95 ± 0.11 | 1.00 ± 0.00 | 1.24 ± 0.03 | 1.32 ± 0.16 | 3.07 ± 0.05 | 3.26 ± 0.40 | 4.31 ± 0.06 | 4.59a ± 0.60 |
| AFO | 1.14 ± 0.06 | 1.00 ± 0.00 | 1.67 ± 0.02 | 1.47 ± 0.07 | 3.82 ± 0.02 | 3.36 ± 0.18 | 5.58 ± 0.04 | 4.91ab ± 0.29 |
| ML | 2.34 ± 0.11 | 1.00 ± 0.00 | 3.14 ± 0.02 | 1.34 ± 0.06 | 6.86 ± 0.12 | 2.94 ± 0.10 | 16.83 ± 0.10 | 7.21b ± 0.36 |
# Values within the same column with different superscript letters are significantly different (p < 0.05) according to Tukey’s HSD test. *Resistance ratios (RRs) were calculated by dividing the IC50 value of the generation under investigation by the IC50 value of the parental strain (first generation).
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