Repositioning of moxidectin: a promising approach in cutaneous leishmaniasis therapy

Open Access

Table 1

Efficacy of antiparasitic drugs against all developmental stages of L. tropica.

	Ivermectin	Permethrin	Moxidectin	Afoxolaner	Miltefosine	p-value
	IC₅₀ ± SE (μM)
Promastigotes	0.69 ± 0.04^a#	1.72 ± 0.01^b	0.58 ± 0.01^a	0.6 ± 0.01^a	1.57 ± 0.03^c	<0.05
Axenic amastigotes	0.64 ± 0.00^a	1.05 ± 0.02^b	0.52 ± 0.01^c	0.63 ± 0.00^a	1.1 ± 0.04^b	<0.05
Intracellular amastigotes	1.32 ± 0.07^a	2.12 ± 0.04^c	0.94 ± 0.06^b	1.13 ± 0.03^ab	2.33 ± 0.06^c	<0.05
	CC₅₀ ± SE (μM)
THP-1 cells	60.44 ± 0.99^a	42.66 ± 0.58^b	60.29 ± 0.39^a	60.70 ± 1.06^a	62.33 ± 0.79^a	<0.05
	Selectivity Index*
	45.67 ± 2.45^a	20.07 ± 0.5^c	63.49 ± 4.3^b	53.29 ± 1.87^ab	26.75 ± 0.79^c	<0.05

Values within the same row with different superscript letters are significantly different (p < 0.05) according to Tukey’s HSD test. *Selectivity Index was calculated as the ratio of CC₅₀ (THP-1 cells) to IC₅₀ (intracellular amastigotes).

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