Open Access
Issue
Parasite
Volume 33, 2026
Article Number 14
Number of page(s) 18
DOI https://doi.org/10.1051/parasite/2026013
Published online 23 March 2026
  1. Abdellahi M, Ndir O, Niang S.. 2016. Évaluation de la prévalence des bilharzioses auprès des enfants de 5 à 14 ans après plusieurs années de traitement de masse dans le bassin du fleuve Sénégal. Santé Publique, 28(4), 535–540. [Google Scholar]
  2. Abel L, Dessein AJ. 1997. The impact of host genetics on susceptibility to human infectious diseases. Current opinion in Immunology, 9(4), 509–516. [Google Scholar]
  3. Agniwo P, Sidibé B, Diakité A, Niaré SD, Guindo H, Akplogan A, Ibikounlé M, Boissier J, Dabo A. 2023. Ultrasound aspects and risk factors associated with urogenital schistosomiasis among primary school children in Mali. Infectious Diseases of Poverty, 12(1), 40. [CrossRef] [PubMed] [Google Scholar]
  4. Amoani B, Adu B, Frempong MT, Sarkodie-Addo T, Nuvor SV, Wilson MD, Gyan B. 2019. Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana. PLoS One, 14(9), e0222382. [Google Scholar]
  5. Asuming-Brempong E, Gyan B, Amoah AS, van der Puije W, Bimi L, Boakye D, Ayi I. 2015. Relationship between eosinophil cationic protein and infection intensity in a schistosomiasis endemic community in Ghana. Research and reports in Tropical Medicine, 6, 1–10. [Google Scholar]
  6. Ayabina DV, Clark J, Bayley H, Lamberton PH, Toor J, Hollingsworth TD. 2021. Gender-related differences in prevalence, intensity and associated risk factors of Schistosoma infections in Africa: A systematic review and meta-analysis. PLoS Neglected Tropical Diseases, 15(11), e0009083. [Google Scholar]
  7. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21(2), 263–265. [CrossRef] [PubMed] [Google Scholar]
  8. Bethony JM, Quinnell RJ. 2008. Genetic epidemiology of human schistosomiasis in Brazil. Acta Tropica, 108(2–3), 166–174. [Google Scholar]
  9. Bintou L, Sodio B, Sacko M. 2019. Persistance de la schistosomiase urinaire en zones endémiques soumises aux traitements de masse répétés au Mali. International Journal of Biological and Chemical Sciences, 13(1), 369–381. [Google Scholar]
  10. Bocanegra C, Pintar Z, Mendioroz J, Serres X, Gallego S, Nindia A, Aznar ML, Soriano-Arandes A, Salvador F, Gil E. 2018. Ultrasound evolution of pediatric urinary schistosomiasis after treatment with praziquantel in a highly endemic area. American Journal of Tropical Medicine and Hygiene, 99(4), 1011. [Google Scholar]
  11. Boissier J, Mouahid G, Moné H. 2019. Rose JB, Jiménez-Cisneros B, Schistosoma spp., in: Global Water Pathogen Project, Michigan State University, E. Lansing, MI, UNESCO. [Google Scholar]
  12. Boix E, Torrent M, Sánchez D, Nogues MV. 2008. The antipathogen activities of eosinophil cationic protein. Current pharmaceutical biotechnology, 9(3), 141–152. [Google Scholar]
  13. Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Freeman C, Galichet L. 2009. A review of human carcinogens – Part B: biological agents. Lancet Oncology, 10(4), 321–322. [Google Scholar]
  14. Burke M, Jones M, Gobert G, Li Y, Ellis M, McManus D. 2009. Immunopathogenesis of human schistosomiasis. Parasite Immunology, 31(4), 163–176. [Google Scholar]
  15. Cheever AW, Duvall RH. 1981. Bladder calcification and obstructive uropathy in a gibbon infected with Schistosoma haematobium. American Journal of Tropical Medicine and Hygiene, 30(3), 604–608. [Google Scholar]
  16. Cheever AW, Hoffmann KF, Wynn TA. 2000. Immunopathology of schistosomiasis mansoni in mice and men. Immunology Today, 21(9), 465–466. [Google Scholar]
  17. Cheever AW, Young SW, Shehata A. 1975. Calcification of Schistosoma haematobium eggs: relation of radiologically demonstrable calcification to eggs in tissues and passage of eggs in urine. Transactions of the Royal Society of Tropical Medicine and Hygiene, 69(4), 410–414. [Google Scholar]
  18. Colley D, Secor W. 2014. Immunology of human schistosomiasis. Parasite Immunology, 36(8), 347–357. [CrossRef] [PubMed] [Google Scholar]
  19. Colley DG, Bustinduy AL, Secor WE, King CH. 2014. Human schistosomiasis. Lancet, 383(9936), 2253–2264. [CrossRef] [PubMed] [Google Scholar]
  20. Dessein A, Rihet P, Demeure C, Couissinier P, Bacellar O, Carvalho EM, Kohlstaedt S, Dessein H, Souza A, Prata A. 1992. Facteurs génétiques et immunologiques déterminant la résistance à la bilharziose en région d’endémie. Médecine Sciences, 8, 108–118. [Google Scholar]
  21. Dessein H, Duflot N, Romano A, Opio C, Pereira V, Mola C, Kabaterene N, Coutinho A, Dessein A. 2020 Genetic algorithms identify individuals with high risk of severe liver disease caused by schistosomes. Human Genetics, 139, 821–831. [Google Scholar]
  22. Edgar RC. 2004. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Research, 32(5), 1792–1797. [CrossRef] [PubMed] [Google Scholar]
  23. El-Tahan RR, Ghoneim AM, El-Mashad N. 2016. TNF-α gene polymorphisms and expression. Springerplus, 5, 1–7. [CrossRef] [PubMed] [Google Scholar]
  24. Elmadani AE, Hamdoun AO, Monis A, Karamino NE, Gasmelseed N. 2013. Ultrasound findings in urinary shistosomaisis infection in school children in the Gezira State Central Sudan. Saudi Journal of Kidney Diseases and Transplantation, 24(1), 162–167. [Google Scholar]
  25. Eriksson J, Reimert CM, Kabatereine NB, Kazibwe F, Ireri E, Kadzo H, Eltahir HB, Mohamed AO, Vennervald BJ, Venge P. 2007. The 434 (G > C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection. International Journal for Parasitology, 37(12), 1359–1366. [Google Scholar]
  26. Fall CB, Lambert S, Léger E, Yasenev L, Garba AD, Diop SD, Borlase A, Catalano S, Faye B, Walker M. 2021. Hybridized zoonotic Schistosoma infections result in hybridized morbidity profiles: A clinical morbidity study amongst co-infected human populations of Senegal. Microorganisms, 9(8), 1776. [Google Scholar]
  27. Fettrelet T, Gigon L, Karaulov A, Yousefi S, Simon H-U. 2021. The enigma of eosinophil degranulation. International Journal of Molecular Sciences, 22(13), 7091. [Google Scholar]
  28. Fulkerson PC, Rothenberg ME. 2013. Targeting eosinophils in allergy, inflammation and beyond. Nature reviews Drug Discovery, 12(2), 117–129. [Google Scholar]
  29. Fumagalli M, Pozzoli U, Cagliani R, Comi GP, Bresolin N, Clerici M, Sironi M. 2010. The landscape of human genes involved in the immune response to parasitic worms. BMC Evolutionary Biology, 10, 1–15. [Google Scholar]
  30. Gaye AM, Doh K, Thiam I, Bentefouet L, Woto-Gaye G. 2016. Bilharziose et cancer: une association fortuite ou une relation de cause à effet. Bulletin du Cancer, 103(9), 806–807. [Google Scholar]
  31. Gryseels B, Polman K, Clerinx J, Kestens L. 2006. Human schistosomiasis. Lancet, 368(9541), 1106–1118. [CrossRef] [PubMed] [Google Scholar]
  32. Gurarie D, Yoon N, Li E, Ndeffo-Mbah M, Durham D, Phillips AE, Aurelio HO, Ferro J, Galvani AP, King CH. 2015. Modelling control of Schistosoma haematobium infection: predictions of the long-term impact of mass drug administration in Africa. Parasites & vectors, 8(1), 1–14. [Google Scholar]
  33. Hesse M, Piccirillo CA, Belkaid Y, Prufer J, Mentink-Kane M, Leusink M, Cheever AW, Shevach EM, Wynn TA. 2004. The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. Journal of Immunology, 172(5), 3157–3166. [Google Scholar]
  34. Huyse T, Van den Broeck F, Hellemans B, Volckaert F, Polman K. 2013. Hybridisation between the two major African schistosome species of humans. International Journal for Parasitology, 43(8), 687–689. [CrossRef] [PubMed] [Google Scholar]
  35. IA RC. 2012. IARC. Biological Agents: Monographs on the evaluation of carcinogenic risks to humans. International Agency for Research on Cancer, Lyon, France, 100B, 499. [Google Scholar]
  36. Imarenezor E, Nmorsi O, Brown S, Abhadionmhen OYaO. 2016. Interleukin (IL)–10 and tumour necrosis factor–alpha (TNF–α) profiles of individuals with Schistosoma haematobium infection in Ewan community, Edo state, Nigeria. FUW Trends in Science & Technology Journal, 1, 24–26. [Google Scholar]
  37. Joekes E, McMonnies K, Blanshard A, Mutuku FM, Ireri E, Mungai P, Stothard JR, Bustinduy AL, King CH. 2023. A 14-year follow-up of ultrasound-detected urinary tract pathology associated with urogenital schistosomiasis in women living in the Msambweni region of coastal Kenya. Transactions of The Royal Society of Tropical Medicine and Hygiene, 117(9), 637–644. [Google Scholar]
  38. Jönsson UB, Byström J, Stålenheim G, Venge P. 2002. Polymorphism of the eosinophil cationic protein‐gene is related to the expression of allergic symptoms. Clinical & Experimental Allergy, 32(7), 1092–1095. [Google Scholar]
  39. Kamdem SD, Moyou-Somo R, Brombacher F, Nono JK. 2018. Host regulators of liver fibrosis during human schistosomiasis. Frontiers in Immunology, 9, 2781. [Google Scholar]
  40. King CH. 2002 Ultrasound monitoring of structural urinary tract disease in Schistosoma haematobium infection. Memórias do Instituto Oswaldo Cruz, 97, 149–152. [Google Scholar]
  41. King CL, Malhotra I, Mungai P, Wamachi A, Kioko J, Muchiri E, Ouma JH. 2001. Schistosoma haematobium induced urinary tract morbidity correlates with increased tumor necrosis factor-α and diminished interleukin-10 production. Journal of Infectious Diseases, 184(9), 1176–1182. [Google Scholar]
  42. Kumar S, Stecher G, Tamura K. 2016. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Molecular Biology and Evolution, 33(7), 1870–1874. [CrossRef] [PubMed] [Google Scholar]
  43. Kwok AJ, Mentzer A, Knight JC. 2021. Host genetics and infectious disease: new tools, insights and translational opportunities. Nature Reviews Genetics, 22(3), 137–153. [Google Scholar]
  44. Leutscher P, Raharisolo C, Pecarrere J, Ravaoalimalala V, Serieye J, Rasendramino M, Vennervald B, Feldmeier H, Esterre P. 1997. Schistosoma haematobium induced lesions in the female genital tract in a village in Madagascar. Acta Tropica, 66(1), 27–33. [Google Scholar]
  45. Leutscher P, Ramarokoto C-E, Reimert C, Feldmeier H, Esterre P, Vennervald BJ. 2000. Community-based study of genital schistosomiasis in men from Madagascar. Lancet, 355(9198), 117–118. [Google Scholar]
  46. Leutscher PD, Reimert CM, Vennervald BJ, Ravaoalimalala VE, Ramarokoto CE, Serieye J, Raobelison A, Rasendramino M, Christensen NO, Esterre P.. 2000. Morbidity assessment in urinary schistosomiasis infection through ultrasonography and measurement of eosinophil cationic protein (ECP) in urine. Tropical Medicine & International Health, 5(2), 88–93. [Google Scholar]
  47. Lundy SK, Lukacs NW. 2013. Chronic schistosome infection leads to modulation of granuloma formation and systemic immune suppression. Frontiers in Immunology, 4, 39. [CrossRef] [PubMed] [Google Scholar]
  48. Ma SM, Adamu B. 2015. Pattern of urinary bladder sonographic findings in patients evaluated for urinary schistosomiasis. West African Journal of Radiology, 22(2), 92–96. [Google Scholar]
  49. Magak P, Chang-CojulunA, Kadzo H, Ireri E, Muchiri E, Kitron U, King CH. 2015. Case–control study of posttreatment regression of urinary tract morbidity among adults in Schistosoma haematobium endemic communities in Kwale County, Kenya. American Journal of Tropical Medicine and Hygiene, 93(2), 371. [Google Scholar]
  50. Mahmoud AA. 1982. The ecology of eosinophils in schistosomiasis. Journal of Infectious Diseases, 145(5), 613–622. [Google Scholar]
  51. Marquet S, Abel L, Hillaire D, Dessein A. 1999. Full results of the genome-wide scan which localises a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31–q33. European Journal of Human Genetics, 7(1), 88–97. [Google Scholar]
  52. Marume A, Chimponda T, Vengesai A, Mushayi C, Mann J, Mduluza T. 2021. Effects of TNF-α and IL-10–819 T > C single nucleotide polymorphisms on urogenital schistosomiasis in preschool children in Zimbabwe. African Journal of Laboratory Medicine, 10(1), 1–7. [Google Scholar]
  53. Masamba P, Kappo AP. 2021. Immunological and biochemical interplay between cytokines, oxidative stress and schistosomiasis. International Journal of Molecular Sciences, 22(13), 7216. [Google Scholar]
  54. Mawa PA, Kincaid-Smith J, Tukahebwa EM, Webster JP, Wilson S. 2021. Schistosomiasis morbidity hotspots: Roles of the human host, the parasite and their interface in the development of severe morbidity. Frontiers in Immunology, 12, 751. [Google Scholar]
  55. McLaren DJ, McKean J, Olsson I, Venge P, Kay A. 1981. Morphological studies on the killing of schistosomula of Schistosoma mansoni by human eosinophil and neutrophil cationic proteins in vitro. Parasite Immunology, 3(4), 359–373. [Google Scholar]
  56. McLaren DJ, Peterson C, Venge P. 1984. Schistosoma mansoni: further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro. Parasitology, 88(3), 491–503. [Google Scholar]
  57. McManus D, Dunne DW, Sacko M, Utzinger J, Vennervald BJ, Zhou X-N. 2018. Schistosomiasis. Nature Reviews Diseases Primers, 4, 13. [Google Scholar]
  58. Mewamba EM, Noyes H, Tiofack AAZ, Kamga RMN, Kamdem CN, Mengoue LET, Ofon E, Ngassam RIK, Nyangiri O, Bucheton B. Association between polymorphisms of IL4, IL13, IL10, STAT6 and IFNG genes, cytokines and immunoglobulin E levels with high burden of Schistosoma mansoni in children from schistosomiasis endemic areas of Cameroon. Infection, Genetics and Evolution, 111, 105416. [Google Scholar]
  59. Mewamba EM, Nyangiri OA, Noyes HA, Egesa M, Matovu E, Simo G. 2021. The genetics of human schistosomiasis infection intensity and liver disease: A review. Frontiers in Immunology, 12, 613468. [Google Scholar]
  60. Midzi N, Mduluza T, Mudenge B, Foldager L, Leutscher PD. 2017. Decrease in seminal HIV-1 RNA load after praziquantel treatment of urogenital schistosomiasis coinfection in HIV-positive men an observational study. Open Forum Infectious Diseases. US: Oxford University Press. [Google Scholar]
  61. Midzi N, Ndhlovu PD, Nyanga L, Kjetland E, Reimert C, Vennervald B, Gomo E, Mudenge G, Friis H, Gundersen S. 2003. Assessment of eosinophil cationic protein as a possible diagnostic marker for female genital schistosomiasis in women living in a Schistosoma haematobium endemic area. Parasite Immunology, 25(11–12), 581–588. [Google Scholar]
  62. Midzi N, Ndhlovu PD, Nyanga L, Kjetland EF, Reimert CM, Vennervald BJ, Gomo E, Mudenge G, Friis H, Gundersen SG, Mduluza T. 2003. Assessment of eosinophil cationic protein as a possible diagnostic marker for female genital schistosomiasis in women living in a Schistosoma haematobium endemic area., Parasite Immunology, 25(11–12), 581–588. [Google Scholar]
  63. Molfino N, Gossage D, Kolbeck R, Parker J, Geba G. 2012. Molecular and clinical rationale for therapeutic targeting of interleukin‐5 and its receptor. Clinical & Experimental Allergy, 42(5), 712–737. [Google Scholar]
  64. Müller-Myhsok B, Stelma FF, Guisse-Sow F, Muntau B, Thye T, Burchard GD, Gryseels B, Horstmann RD. 1997. Further evidence suggesting the presence of a locus, on human chromosome 5q31–q33, influencing the intensity of infection with Schistosoma mansoni. American Journal of Human Genetics, 61(2), 452. [Google Scholar]
  65. Mutapi F, Burchmore R, Mduluza T, Midzi N, Turner CMR, Maizels RM. 2008. Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population. Journal of Infectious Diseases, 198(2), 167–175. [Google Scholar]
  66. Mutengo MM, Mduluza T, Kelly P, Mwansa JC, Kwenda G, Musonda P, Chipeta J. 2018. Low IL‐6, IL‐10, and TNF‐α and high IL‐13 cytokine levels are associated with severe hepatic fibrosis in Schistosoma mansoni chronically exposed individuals. Journal of Parasitology Research, 2018(1), 9754060. [Google Scholar]
  67. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM. 2017. A guiding map for inflammation. Nature Immunology, 18(8), 826–831. [Google Scholar]
  68. Olveda DU, Ross AG. 2017. Chronic schistosomiasis, in: Schistosoma. CRC Press. pp. 368–386. [Google Scholar]
  69. Onzo-Aboki A, Ibikounlé M, Boko PM, Savassi BS, Doritchamou J, Siko EJ, Daré A, Batcho W, Massougbodji A, Tougoue JJ. 2019. Human schistosomiasis in Benin: Countrywide evidence of Schistosoma haematobium predominance. Acta Tropica, 191, 185–197. [Google Scholar]
  70. Palumbo E. 2007. Association between schistosomiasis and cancer: a review. Infectious Diseases in Clinical Practice, 15(3), 145–148. [Google Scholar]
  71. Pereira MC, Oliveira DT, Olivieri EH, Rogatto SR, Carvalho AL, Landman G, Kowalski LP. 2010. The 434 (G > C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas. Journal of Oral Pathology & Medicine, 39(1), 56–62. [Google Scholar]
  72. Perera DJ, Koger-Pease C, Paulini K, Daoudi M, Ndao M. 2024. Beyond schistosomiasis: unraveling co-infections and altered immunity. Clinical Microbiology Reviews, 37(1), e00098-23. [Google Scholar]
  73. Peters P, Mahmoud AA, Warren K, Ouma J, Siongok TA. 1976. Field studies of a rapid, accurate means of quantifying Schistosoma haematobium eggs in urine samples. Bulletin of the World Health Organization, 54(2), 159. [Google Scholar]
  74. Pinot de Moira A, Fulford AJ, Kabatereine NB, Ouma JH, Booth M, Dunne DW. 2010. Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: the influence of age, sex, ethnicity and IgE. PLoS Neglected Tropical Diseases, 4(9), e820. [CrossRef] [PubMed] [Google Scholar]
  75. Randrianasolo BS, Jourdan PM, Ravoniarimbinina P, Ramarokoto CE, Rakotomanana F, Ravaoalimalala VE, Gundersen SG, Feldmeier H, Vennervald BJ, Van Lieshout L. 2015. Gynecological manifestations, histopathological findings, and schistosoma-specific polymerase chain reaction results among women with Schistosoma haematobium infection: a cross-sectional study in Madagascar. Journal of Infectious Diseases, 212(2), 275–284. [Google Scholar]
  76. Reimert C, Venge P, Kharazmi A, Bendtzen K. 1991. Detection of eosinophil cationic protein (ECP) by an enzyme-linked immunosorbent assay. Journal of Immunological Methods, 138(2), 285–290. [Google Scholar]
  77. Reimert CM, Fitzsimmons CM, Joseph S, Mwatha JK, Jones FM, Kimani G, Hoffmann KF, Booth M, Kabatereine NB, Dunne DW, Vennervald BJ. 2006. Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with Praziquantel. Clinical and Vaccine Immunology, 13(5), 584–593. [Google Scholar]
  78. Reimert CM, Mshinda HM, Hatz CF, Kombe Y, Nkulila T, Poulsen LK, Christensen N, Vennervald B. 2000. Quantitative assessment of eosinophiluria in Schistosoma haematobium infections: a new marker of infection and bladder morbidity. American Journal of Tropical Medicine and Hygiene, 62(1), 19–28. [Google Scholar]
  79. Richter J, Botelho M, Holtfreter M, Akpata R, El Scheich T, Neumayr A, Brunetti E, Hatz C, Dong Y, Dietrich CF. 2016 Ultrasound assessment of schistosomiasis. Zeitschrift für Gastroenterologie, 54(07), 653–660. [Google Scholar]
  80. Richter J, Hatz C, Campagne G, Bergquist N, Jenkins JM. 2000. Ultrasound in schistosomiasis: a practical guide to the standard use of ultrasonography for assessment of schistosomiasis-related morbidity: Second international workshop, October 22–26 1996. Niamey, Niger: World Health Organization [Google Scholar]
  81. Rollinson D, Southgate VR. 1987. The genus Schistosoma: a taxonomic appraisal, in: The biology of schistosomes from genes to latrines, Academic: London. pp. 350. [Google Scholar]
  82. Ross A, Bartley P, Sleigh A. 2002. Schistosomiasis. New England Journal of Medicine, 346, 1212–1220. [Google Scholar]
  83. Rozas J, Ferrer-Mata A, Sánchez-DelBarrio JC, Guirao-Rico S, Librado P, Ramos-Onsins SE, Sánchez-Gracia A. 2017. DnaSP 6: DNA sequence polymorphism analysis of large data sets. Molecular Biology and Evolution, 34(12), 3299–3302. [CrossRef] [PubMed] [Google Scholar]
  84. Sakyi SA, Amoani B, Opoku S, Dzata L, Aniagyei W, Senu E, Dankwa K, Wilson MD. 2022. Assessing the role of eosinophil-mediated immune response markers in detecting hookworm infection: A case-control study in Kintampo, Ghana. Health Science Reports, 5(4), e674. [Google Scholar]
  85. Savassi BA, Dobigny G, Etougbétché JR, Avocegan TT, Quinsou FT, Gauthier P, Ibikounlé M, Moné H, Mouahid G. 2021. Mastomys natalensis (Smith, 1834) as a natural host for Schistosoma haematobium (Bilharz, 1852) Weinland, 1858 x Schistosoma bovis Sonsino, 1876 introgressive hybrids. Parasitology Research, 120(5), 1755–1770. [CrossRef] [PubMed] [Google Scholar]
  86. Savassi BAES, Mouahid G, Lasica C, Mahaman SK, Garcia A, Courtin D, Allienne JF, Ibikounlé M, Moné H. 2020. Cattle as natural host for Schistosoma haematobium (Bilharz, 1852) Weinland, 1858 x Schistosoma bovis Sonsino, 1876 interactions, with new cercarial emergence and genetic patterns. Parasitology Research, 119(7), 2189–2205. [CrossRef] [PubMed] [Google Scholar]
  87. Shebel HM, Elsayes KM, Abou El Atta HM, Elguindy YM, El-Diasty TA. Genitourinary schistosomiasis: life cycle and radiologic-pathologic findings. Radiographics, 32(4), 1031–1046. [Google Scholar]
  88. Shen Z, Luo H. 2025 The impact of schistosomiasis on the Global Disease Burden: a systematic analysis based on the 2021 Global Burden of Disease study. Parasite, 32, 12. [Google Scholar]
  89. Silva PCV, Gomes AV, de Britto LRPB, de Lima ELS, da Silva JL, Montenegro SML, Muniz MTC, Domingues ALC. 2017. Influence of a TNF-α polymorphism on the severity of schistosomiasis periportal fibrosis in the northeast of Brazil. Genetic Testing and Molecular Biomarkers, 21(11), 658–662. [Google Scholar]
  90. Trienekens SC, Faust CL, Meginnis K, Pickering L, Ericsson O, Nankasi A, Moses A, Tukahebwa EM, Lamberton PH. 2020. Impacts of host gender on Schistosoma mansoni risk in rural Uganda — A mixed-methods approach PLoS Neglected Tropical Diseases, 14(5), e0008266. [Google Scholar]
  91. Trulson A, Byström J, Engström Å, Larsson R, Venge P. 2007. The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post‐translational modifications. Clinical & Experimental Allergy, 37(2), 208–218. [Google Scholar]
  92. Wamachi AN, Mayadev JS, Mungai PL, Magak PL, Ouma JH, Magambo JK, Muchiri EM, Koech DK, King CH, King C. 2004. Increased ratio of tumor necrosis factor-α to interleukin-10 production is associated with Schistosoma haematobium-induced urinary-tract morbidity. Journal of Infectious Diseases, 190(11), 2020–2030. [Google Scholar]
  93. Wang X, Tang Q, Bergquist R, Zhou X, Qin Z. 2023. The cytokine profile in different stages of schistosomiasis japonica. Pathogens, 12(10), 1201. [Google Scholar]
  94. WHO. 2002. Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. World Health Organization. [Google Scholar]
  95. WHO. 2011. Report of a meeting to review the results of studies on the treatment of schistosomiasis in preschool-age children. p. 32. [Google Scholar]
  96. WHO. 2020. Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. World Health Organization. [Google Scholar]
  97. WHO. 2022. Ending the neglect to attain the sustainable development goals: One health: approach for action against neglected tropical diseases 2021–2030. World Health Organization. [Google Scholar]
  98. WHO. 2022. WHO guideline on control and elimination of human schistosomiasis. World Health Organization. [Google Scholar]
  99. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. 1997. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proceedings of the National Academy of Sciences, 94(7), 3195–3199. [Google Scholar]
  100. Wilson MS, Mentink-Kane MM, Pesce JT, Ramalingam TR, Thompson R, Wynn TA. 2007. Immunopathology of schistosomiasis. Immunology and cell Biology, 85(2), 148–154. [Google Scholar]
  101. Wilson RA, Coulson PS. 2009. Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite’s armour. Trends in Parasitology, 25(9), 423–431. [Google Scholar]
  102. Woolhouse ME, Dye C, Etard J-F, Smith T, Charlwood J, Garnett G, Hagan P, Hii Jx, Ndhlovu P, Quinnell R. 1997. Heterogeneities in the transmission of infectious agents: implications for the design of control programs. Proceedings of the National Academy of Sciences, 94(1), 338–342. [Google Scholar]
  103. Wynn TA, Thompson RW, Cheever AW, Mentink‐Kane MM. 2004. Immunopathogenesis of schistosomiasis. Immunological Reviews, 201(1), 156–167. [Google Scholar]

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