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All issues Volume 32 (2025) Parasite, 32 (2025) 71 References
Open Access
Issue
Parasite
Volume 32, 2025
Article Number 71
Number of page(s) 10
DOI https://doi.org/10.1051/parasite/2025066
Published online 24 November 2025
  1. Allen MJ, Morby AP, White GF. 2004. Cooperativity in the binding of the cationic biocide polyhexamethylene biguanide to nucleic acids. Biochemical and Biophysical Research Communications, 318(2), 397–404. [CrossRef] [PubMed] [Google Scholar]
  2. Allen MJ, White GF, Morby AP. 2006. The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide. Microbiology, 152(4), 989–1000. [CrossRef] [PubMed] [Google Scholar]
  3. Auran JD, Starr MB, Jakobiec FA. 1987. Acanthamoeba keratitis. Cornea, 6(1), 2–26. [CrossRef] [PubMed] [Google Scholar]
  4. Bahrami S, Asadi Z, Zarei M, Hamidinejat H, Henriquez FL. 2023. Exposure to sublethal concentrations of chlorine enhances the cytotoxicity of Acanthamoeba castellanii. Parasitology Research, 122(6), 1371–1380. [Google Scholar]
  5. Brown T, Cursons R, Keys E. 1982. Amoebae from antarctic soil and water. Applied and Environmental Microbiology, 44(2), 491–493. [CrossRef] [PubMed] [Google Scholar]
  6. Broxton P, Woodcock P, Gilbert P. 1983. A study of the antibacterial activity of some polyhexamethylene biguanides towards Escherichia coli ATCC 8739. Journal of Applied Bacteriology, 54(3), 345–353. [CrossRef] [Google Scholar]
  7. Corsaro D. 2022. Acanthamoeba mannose and laminin binding proteins variation across species and genotypes. Microorganisms, 10(11), 2162. [Google Scholar]
  8. Dart JK, Papa V, Rama P, Knutsson KA, Ahmad S, Hau S, Sanchez S, Franch A, Birattari F, Leon P. 2024. The Orphan Drug for Acanthamoeba Keratitis (ODAK) Trial: PHMB 0.08%(Polihexanide) and placebo versus PHMB 0.02% and propamidine 0.1%. Ophthalmology, 131(3), 277–287. [Google Scholar]
  9. Di Zazzo A, Varacalli G, De Gregorio C, Coassin M, Bonini S. 2022. Therapeutic corneal transplantation in Acanthamoeba keratitis: penetrating versus lamellar keratoplasty. Cornea, 41(3), 396–401. [Google Scholar]
  10. Dudley R, Alsam S, Khan NA. 2008. The role of proteases in the differentiation of Acanthamoeba castellanii. FEMS Microbiology Letters, 286(1), 9–15. [Google Scholar]
  11. Garate M, Cao Z, Bateman E, Panjwani N. 2004. Cloning and characterization of a novel mannose-binding protein of Acanthamoeba. Journal of Biological Chemistry, 279(28), 29849–29856. [Google Scholar]
  12. Heidemann DG, Verdier DD, Dunn SP, Stamler JF. 1990. Acanthamoeba keratitis associated with disposable contact lenses. American Journal of Ophthalmology, 110(6), 630–634. [Google Scholar]
  13. Hong Y-C, Lee W-M, Kong H-H, Jeong H-J, Chung D-I. 2004. Molecular cloning and characterization of a cDNA encoding a laminin-binding protein (AhLBP) from Acanthamoeba healyi. Experimental Parasitology, 106(3–4), 95–102. [Google Scholar]
  14. Huang F-C, Shih M-H, Chang K-F, Huang J-M, Shin J-W, Lin W-C. 2017. Characterizing clinical isolates of Acanthamoeba castellanii with high resistance to polyhexamethylene biguanide in Taiwan. Journal of Microbiology. Immunology and Infection, 50(5), 570–577. [Google Scholar]
  15. Huang J-M, Ko P-J, Huang C-L, Wen P-W, Chen C-H, Shih M-H, Lin W-C, Huang F-C. 2021. Cytochrome P450 monooxygenase of Acanthamoeba castellanii participates in resistance to polyhexamethylene biguanide treatment. Parasite, 28, 77. [Google Scholar]
  16. Jeong HJ, Lee SJ, Kim JH, Xuan YH, Lee KH, Park SK, Choi SH, Chung DI, Kong HH, Ock MS. 2007. Acanthamoeba: keratopathogenicity of isolates from domestic tap water in Korea. Experimental Parasitology, 117(4), 357–367. [Google Scholar]
  17. Jeong HJ, Yu HS. 2005. The role of domestic tap water in Acanthamoeba contamination in contact lens storage cases in Korea. Korean Journal of Parasitology, 43(2), 47. [Google Scholar]
  18. John T, Desai D, Sahm D. 1989. Adherence of Acanthamoeba castellanii cysts and trophozoites to unworn soft contact lenses. American Journal of Ophthalmology, 108(6), 658–664. [Google Scholar]
  19. Kamaruzzaman NF, Chong SQ, Edmondson-Brown KM, Ntow-Boahene W, Bardiau M, Good L. 2017. Bactericidal and anti-biofilm effects of polyhexamethylene biguanide in models of intracellular and biofilm of Staphylococcus aureus isolated from bovine mastitis. Frontiers in Microbiology, 8, 1518. [CrossRef] [PubMed] [Google Scholar]
  20. Kao P-M, Hsu B-M, Chen N-H, Huang K-H, Huang C-C, Ji D-D, Chen J-S, Lin W-C, Huang S-W, Chiu Y-C. 2012. Molecular detection and comparison of Acanthamoeba genotypes in different functions of watersheds in Taiwan. Environmental Monitoring and Assessment, 184, 4335–4344. [Google Scholar]
  21. Kilvington S. 1993. Acanthamoeba trophozoite and cyst adherence to four types of soft contact lens and removal by cleaning agents. Eye, 7(4), 535–538. [Google Scholar]
  22. Kim W-T, Kong H-H, Ha Y-R, Hong Y-C, Jeong HJ, Yu HS, Chung D-I. 2006. Comparison of specific activity and cytopathic effects of purified 33 kDa serine proteinase from Acanthamoeba strains with different degree of virulence. Korean Journal of Parasitology, 44(4), 321. [Google Scholar]
  23. Lee G-H, Lee J-E, Park M-K, Yu H-S. 2016. Adhesion of Acanthamoeba on silicone hydrogel contact lenses. Cornea, 35(5), 663–668. [Google Scholar]
  24. Li M-L, Shih M-H, Huang F-C, Tseng S-H, Chen C-C. 2012. Treatment of early Acanthamoeba keratitis with alcohol-assisted epithelial debridement. Cornea, 31(4), 442–446. [CrossRef] [PubMed] [Google Scholar]
  25. Lim N, Goh D, Bunce C, Xing W, Fraenkel G, Poole TR, Ficker L. 2008. Comparison of polyhexamethylene biguanide and chlorhexidine as monotherapy agents in the treatment of Acanthamoeba keratitis. American Journal of Ophthalmology, 145(1), 130–135. [CrossRef] [PubMed] [Google Scholar]
  26. Lorenzo-Morales J, Khan NA, Walochnik J. 2015. An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment, Parasite, 22, 10. [CrossRef] [EDP Sciences] [PubMed] [Google Scholar]
  27. Loufouma-Mbouaka A, Martín-Pérez T, Köhsler MDanisman Z, Schwarz M, Mazumdar R, Samba-Louaka A, Walochnik J. 2024. Characterization of novel extracellular proteases produced by Acanthamoeba castellanii after contact with human corneal epithelial cells and their relevance to pathogenesis. Parasites & Vectors, 17(1), 242. [Google Scholar]
  28. Maciver SK, Asif M, Simmen MW, Lorenzo-Morales J. 2013. A systematic analysis of Acanthamoeba genotype frequency correlated with source and pathogenicity: T4 is confirmed as a pathogen-rich genotype. European Journal of Protistology, 49(2), 217–221. [Google Scholar]
  29. McCulley JP, Alizadeh H, Niederkorn JY. 1995. Acanthamoeba keratitis. Eye & Contact Lens, 21(1), 73–76. [Google Scholar]
  30. Mikić IM, Cigić L, Kero D, Govorko DK, Mehičić GP, Andrašević AT, Simeon P. 2018. Antimicrobial effectiveness of polyhexamethylene biguanide on Enterococcus faecalis, Staphylococcus epidermidis and Candida albicans. Medicinski Glasnik, 15(2), 132–138. [Google Scholar]
  31. Moon E-K, Chung D-I, Hong Y-C, Kong H-H. 2008. Characterization of a serine proteinase mediating encystation of Acanthamoeba. Eukaryotic Cell, 7(9), 1513–1517. [Google Scholar]
  32. Moon E-K, Hong Y, Chung D-I, Kong H-H. 2012. Cysteine protease involving in autophagosomal degradation of mitochondria during encystation of Acanthamoeba. Molecular and Biochemical Parasitology, 185(2), 121–126. [CrossRef] [PubMed] [Google Scholar]
  33. Ng S-L, Nordin A, Abd Ghafar N, Suboh Y, Ab Rahim N, Chua K-H. 2017. Acanthamoeba-mediated cytopathic effect correlates with MBP and AhLBP mRNA expression. Parasites & Vectors, 10, 625. [Google Scholar]
  34. Pinna A. 2002. Acanthamoeba and disinfecting contact lens solutions. British Journal of Ophthalmology, 86(12), 1461–1462. [Google Scholar]
  35. Preston T, King C. 1984. Amoeboid locomotion of Acanthamoeba castellanii with special reference to cell-substratum interactions. Microbiology, 130(9), 2317–2323. [Google Scholar]
  36. Putaporntip C, Kuamsab N, Nuprasert W, Rojrung R, Pattanawong U, Tia T, Yanmanee S, Jongwutiwes S. 2021. Analysis of Acanthamoeba genotypes from public freshwater sources in Thailand reveals a new genotype, T23 Acanthamoeba bangkokensis sp. nov. Scientific Reports, 11(1), 17290. [Google Scholar]
  37. Rivera WL, Adao DEV. 2009. 18S ribosomal DNA genotypes of Acanthamoeba species isolated from contact lens cases in the Philippines. Parasitology Research, 105, 1119–1124. [Google Scholar]
  38. Rodríguez MA, Martínez-Higuera A, Valle-Solis MI, Hernandes-Alejandro M, Chávez-Munguía B, Figueroa-Gutiérrez AH, Salas-Casas A. 2018. A putative calcium-ATPase of the secretory pathway family may regulate calcium/manganese levels in the Golgi apparatus of Entamoeba histolytica. Parasitology Research, 117, 3381–3389. [Google Scholar]
  39. Stothard DR, Schroeder-Diedrich JM, Awwad MH, Gast RJ, Ledee DR, Rodriguez-Zaragoza S, Dean CL, Fuerst PA, Byers TJ. 1998. The evolutionary history of the genus Acanthamoeba and the identification of eight new 18S rRNA gene sequence types. Journal of Eukaryotic Microbiology, 45(1), 45–54. [Google Scholar]
  40. Varga JH, Wolf TC, Jensen HG, Parmley VC, Rowsey JJ. 1993. Combined treatment of Acanthamoeba keratitis with propamidine, neomycin, and polyhexamethylene biguanide. American Journal of Ophthalmology, 115(4), 466–470. [CrossRef] [PubMed] [Google Scholar]
  41. Visvesvara GS, Moura H, Schuster FL. 2007. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunology & Medical Microbiology, 50(1), 1–26. [CrossRef] [Google Scholar]
  42. Voyatzis G, McElvanney A. 2007. Bilateral Acanthamoeba keratitis in an experienced two-weekly disposable contact lens wearer. Eye & Contact Lens, 33(4), 201–202. [Google Scholar]
  43. Walls G, Noonan L, Wilson E, Holland D, Briggs S. 2013. Successful use of locally applied polyhexamethylene biguanide as an adjunct to the treatment of fungal osteomyelitis. Canadian Journal of Infectious Diseases and Medical Microbiology, 24(2), 109–112. [CrossRef] [PubMed] [Google Scholar]
  44. Wang L, Asem EK, McLaughlin GL. 1994. Calcium enhances Acanthamoeba polyphaga binding to extracellular matrix proteins. Investigative Ophthalmology & Visual Science, 35(5), 2421–2426. [Google Scholar]
  45. Wang Z, Wu D, Tachibana H, Feng M, X-j Cheng. 2020. Identification and biochemical characterisation of Acanthamoeba castellanii cysteine protease 3. Parasites & Vectors, 13, 592. [Google Scholar]
  46. Werthen M, Davoudi M, Sonesson A, Nitsche D, Mörgelin M, Blom K, Schmidtchen A. 2004. Pseudomonas aeruginosa-induced infection and degradation of human wound fluid and skin proteins ex vivo are eradicated by a synthetic cationic polymer. Journal of Antimicrobial Chemotherapy, 54(4), 772–779. [CrossRef] [PubMed] [Google Scholar]

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