Table 6
Haplotypes (H1 to H12) observed and their frequency according to IMD and IMU groups in patients infected with S. haematobium. Haplotype H1 has only wild-type alleles at the segregation sites, but the other haplotypes (H2 to H12) have at least one mutant allele at one of the segregation sites (see highlighted in black).
| Haplotype TNF-α (dbSNP ID number) | −1031 T > C (rs1799964) | −863 C > A (rs1800630) | −857 C > T (rs1799724) | −308 G > A (rs1800629) | −113 C > G (rs3093660) | +87 G > T (rs2228088) | +489 G > A (rs1800610) | N | IMD |
IMU |
Fisher test p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Frequency (N) | Frequency (N) | ||||||||||
| H1 | T | C | C | G | C | G | G | 44 | 10% (8) | 43% (36) | 2.509e–09 |
| H2 | T | C | C | A | C | G | G | 10 | 4% (3) | 8% (7) | 0.18 |
| H3 | C | A | C | G | C | G | G | 4 | 1% (1) | 4% (3) | 0.49 |
| H4 | T | C | C | G | G | G | G | 6 | 5% (4) | 2% (2) | 0.57 |
| H5 | T | C | C | G | C | T | G | 4 | 1% (1) | 4% (3) | 0.49 |
| H6 | T | C | T | G | C | G | A | 1 | 0% (0) | 1% (1) | NA |
| H7 | T | A | C | G | C | G | G | 6 | 5% (4) | 2% (2) | 0.57 |
| H8 | C | C | C | G | C | G | G | 4 | 4% (3) | 1% (1) | 0.49 |
| H9 | T | C | T | G | C | G | G | 2 | 0% (0) | 2% (2) | 0.33 |
| H10 | T | C | C | G | C | G | A | 1 | 0% (0) | 1% (1) | NA |
| H11 | C | C | C | G | C | T | G | 1 | 1% (1) | 0% (0) | NA |
| H12 | T | A | C | A | C | G | G | 1 | 1% (1) | 0% (0) | NA |
N = sequence number; IMU = infected with morbidity undetected on ultrasound; IMD = infected with morbidity detected on ultrasound. NA = not applicable.
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