Efficacy of oral afoxolaner against Amblyomma maculatum infestations in dogs

Open Access

Table 3

Efficacy of afoxolaner against Amblyomma maculatum infestations 72 hours after treatment and subsequent weekly infestations.

	Day	Day 3	Day 10	Day 17	Day 24	Day 31	Day 38
Study #1	LSC (AM untreated control group)	36.3	35.5	40.8	35.8	32.9	35.5
	LST (AM afoxolaner treated group)	0.0	0.8	0.6	0.4	0.8	1.9
	% efficacy¹	100.0	97.7	98.5	98.9	97.0	94.6
	p-value²	<.0001	<.0001	<.0001	<.0001	<.0001	<.0001
Study #2	AM control group	40.6	–	38.5	–	34.7	–
	AM treated group	0.2	–	0.0	–	0.4	–
	% efficacy¹	99.5	–	100.0	–	98.8	–
	p-value²	<.0001	–	<.0001	–	<.0001	–

The percent reduction was calculated as 100 × [(LS_C − LS_T)/LS_C], where LS_C was the least square arithmetic mean of the live tick counts among the untreated control dogs and LS_T was the least square arithmetic mean of the live tick counts among the IVP-treated dogs.

p-value: Linear mixed model with treatment as a fixed effect and block as a random effect.

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