Open Access
Review

Table 2

Enzyme targets and specific compounds targeted towards Cryptosporidium.

Related enzymatic targets Targeted compounds References
Lactate dehydrogenases (LDH) NSC10447 and NSC158011, Gossypol and FX11 [115, 201]
Calcium-dependent protein kinas 1 (CDPK1) BKI-1517, BKI-1553 [34, 163]
BKI-1534, BKI-1649, BKI-1294, BKI-1369 [91]
Other BKI analogues scaffolded with 5-aminopyrazole-4-carboxamide and pyrrolopyrimidine [88, 90]
Plasmodium lipid kinase (PI(4)K) KDU731 [130]
Nucleoside diphosphate kinase (NDK) Ellagic acid [32]
Inosine monophosphate dehydrogenase (IMPDH) P131 [147]
Thymidylate-synthetase Dihydrofolate Reductase (TS-DHFR) Modified pyrimidine derivatives [110]
tRNA synthetases BRD7929 [177]
Compound 2093 [29]
Compound 5 [22]
Subtilisin-like serine protease 1(SUB1) Peptidic boronic acids [117]
Cysteine Protease (Cryptopains) K11777 [143]
Long-chain fatty acyl-coenzyme A synthetase (LC-ACS) Triacsin C, R134 [39, 72]

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