Bar graphs show the mean±sd fold change in gene expression when compared to the WT. All conditions were performed in triplicate in three independent experiments. Blue corresponds to AAPO; Orange to PAPO-I; Grey to PAPO-II; and Yellow to AQP. LD AQP KO: AQP knock-out; LD AQP EOEs: AQP episomal overexpression; LD AQP KO AB: AQP add-back; LD PAPO-I KO: PAPO-I knock-out. Statistically significant p < 0.005 (*p = 0.0388; ****p = <0.0001) are indicated.