Sequence analyses of CpLTL. (A) Domain organization of CpLTL protein using SMART. SP: signal peptide, TM: transmembrane domain. (B) Amino acid sequences of apicomplexan parasite LTLs were aligned with CpLTL using the Clustal W algorithm. The metal-binding sites were marked with a red arrow, and the carbohydrate-binding sites were marked with a black arrow. Amino acid identities with orthologs from other Cryptosporidium species and apicomplexan parasites.