Immunoprotection evaluation of the recombinant N-terminal domain of Cys-loop receptors against Rhipicephalus (Boophilus) microplus tick infestation

Open Access

Table 1

Control of R. microplus infestations in cattle vaccinated with the recombinant antigens.

Animal	Total tick number			Tick weight (g)^a			Egg weight (g)^b			Egg fertility (%)^c
Animal	Control	rGluCl	rGlyR	Control	rGluCl	rGlyR	Control	rGluCl	rGlyR	Control	rGluCl	rGlyR
1	6854	3614	3764	7.09	6.51	6.14	3.70	3.60	3.33	85.81	83.81	83.49
2	5399	3851	4938	6.55	5.73	7.11	3.48	3.02	3.67	84.12	80.16	84.90
3	2957	3733	3050	5.52	5.20	5.54	2.91	2.79	3.01	83.53	83.43	81.78
Mean ± SD	5070 ± 1607	3732 ± 96	3917 ± 778	6.39 ± 0.65	5.81 ± 0.54	6.26 ± 0.65	3.36 ± 0.33	3.14 ± 0.34	3.34 ± 0.27	84.49 ± 0.97	82.47 ± 1.64	83.39 ± 1.28
% reduction	–	26.39*	22.74*	–	9.08	2.03	–	6.55	0.59	–	2.39	1.3
t-test^d	*P < 0.05
% efficacy^e	rGluCl – 33%
% efficacy^e	rGlyR – 25%

Mean weight of 20 tick specimens.

Mean egg weight from 20 tick specimens.

Mean hatching percentage of eggs from 20 tick specimens.

Total tick number, tick weight, egg weight and egg fertility values were compared by Student’s t-test with unequal variance between vaccinated and control groups (*p < 0.05).

Vaccine efficacy was calculated as 100[1 − (CRT × CRO × CRF)], where CRT, CRO and CRF are the reduction in the number of adult female ticks, oviposition and egg fertility as compared to the control group, respectively.

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