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All issues Volume 28 (2021) Parasite, 28 (2021) 25 Full HTML

Table 2

Efficacy of NexGard® Combo against Amblyomma americanum.

Study Group n Arithmetic means (AM) of live ticks and % efficacy 72 h after treatment or subsequent infestations
Day 3 Day 10 Day 17 Day 24 Day 33
#1 Control1 10 AM 18.8 24.0 23.7 22.7 25.0
Novel formulation2 10 AM 0.1 0.4 1.7 1.3 2.1
% efficacy3 99.5 98.1 93.0 94.1 91.6
p-value4 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
p-value dead ticks <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
#2 Control1 10(9)5 AM 27.0 – 32.1 – 26.3
Novel formulation2 10 AM 0.2 – 0.0 – 0.0
% efficacy3 99.3 – 100.0 – 100.0
p-value4 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
P-value Dead ticks <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
1

Cats were treated topically once on Day 0, each with 0.12 mL/kg mineral oil.

2

Cats were treated topically once on Day 0, each with 0.12 mL/kg of the novel formulation, providing 1.44 mg/kg esafoxolaner, 0.48 mg/kg eprinomectin, and 10.0 mg/kg praziquantel.

3

Percent efficacy = 100[(C − T)/C], where T and C are arithmetic means (AM) of the novel formulation and control groups, respectively.

4

p-value = two-sided probability value from analysis of variance using the MIXED model to compare the novel formulation group with the control group.

5

Ten cats on Day 3, then 9 cats on Days 17 and 33, because one cat died on Day 15 with acute cytauxzoonosis.

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