Evaluation of immune protection against Toxoplasma gondii infection in mice induced by a multi-antigenic DNA vaccine containing TgGRA24, TgGRA25 and TgMIC6

Open Access

Table 1

Mean cyst burden per mouse brain 4 weeks after challenge with 20 cysts of Toxoplasma gondii Pru strain per mouse.

Group (n = 3)	No of brain cysts (Means ± SD)	Reduction (%)
Blank control	3011 ± 101^*	–
pVAX I	2967 ± 110^*	1.4
PBS	2980 ± 112^*	1.03
pVAX-GRA24	2137 ± 99^**	29.03
pVAX-GRA25	1780 ± 129^**	40.88
pVAX-MIC6	1876 ± 113^**	37.70
pVAX-GRA24 + pVAX-GRA25	1564 ± 102^**	48.06
pVAX-GRA24 + pVAX-GRA25 + pVAX-MIC6	1334 ± 96^**	55.37

No statistically significant difference (p > 0.05) between different immunized groups from the same measurement.

^**

Statistically significant difference (p < 0.05).

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