Table 4
Features of children who recovered from persistent early-appearing anaemia and who subsequently progressed to late-appearing anaemia.
Patient (gender, age) | Parasitaemia (μL−1) | Pre-treatment HCT (%) | Antimalarial treatment | PRRD2 | PCT (days) | Nadir HCT at PEAA (%)b,c | Anaemia recovery time (day) | Time to LAA (day)d | Nadir HCT at LAA (%)b,c | HCT on day 42 (%) | Time between recovery and LAA (day) |
---|---|---|---|---|---|---|---|---|---|---|---|
AD57 (M, 24m) | 53,678 | 36 | DHP | 53,678 | 2 | 25 | 33 | 42 | 27 | 27 | 7 |
AD67 (F, 38m) | 23,670 | 30 | AA | 23,670 | 1 | 26 | 13 | 35 | 26 | 30 | 21 |
IM/E/47 (F, 59m) | 4846 | 30 | AA | 4846 | 2 | 26 | 20 | 35 | 28 | 28 | 14 |
IM/E/50 (F, 14m) | 151,733 | 30 | AA | 151,733 | 2 | 25 | 20 | 42 | 25 | 25 | 21 |
IM/E/66 (F, 59m) | 27,965 | 30 | AL | 27,965 | 1 | 26 | 13 | 21 | 28 | 28 | 7 |
KN/EN/90 (F, 24m) | 30,166 | 30 | DHP | 30,166 | 1 | 23 | 13 | 35 | 29 | 38 | 21 |
KW10 (F, 42m) | 120,050 | 34 | AL | 5002 | 3 | 23 | 20 | 28 | 29 | 32 | 7 |
SK18 (M, 16m) | 4842 | 33 | AL | 4842 | 2 | 26 | 13 | 35 | 25 | 26 | 21 |
SK31 (F, 27m) | 8538 | 31 | AL | 94.87 | 3 | 20 | 13 | 28 | 20 | 25 | 14 |
SK46 (F, 19m) | 2004 | 31 | AA | 11.93 | 3 | 24 | 19 | 28 | 23 | – | 7 |
Mean (95% CI) | 19,473 a | 31.5 (30–33) | 5413 a | 1.8 (1.3–2.5) | 24.4 (23–25.8) | 16.9 (13.5–21.1) | 32.3 (27.7–37.6) | 26 (23.9–28) | 27.8 (25.6–32) | 12 (8.6–18.1) |
m, month; AA, artesunate-amodiaquine; AL, artemether-lumefantrine; DHP, dihydroartemisinin-piperaquine; PCT, parasite clearance time; HCT, haematocrit; CI, confidence interval; PEAA, persistent early-appearing anaemia; LAA, late-appearing anaemia.
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