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Table 3

List of compounds from Asteraceae commonly reported for their antiparasitic properties.

Plant1 Name of the compounds/group Organism tested References
Acanthospermum hispidum DC. Sesquiterpenic lactones Plasmodium falciparum [34]
Acmella ciliate (Kunth) Cass. Spilanthol Trypanosoma brucei rhodesiense and Plasmodium falciparum [137]
Ageratum conyzoides (L.) L. Methoxylated flavonoids Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani and Plasmodium falciparum [98]
Ambrosia tenuifolia Spreng. Psilostachyin Leishmania mexicana [143]
  Peruvin    
Ambrosia tenuifolia Spreng. and Ambrosia scabra Hook. & Arn. Psilostachyin and psilostachyin C Trypanosoma cruzi [143]
Artemisia annua L. Sesquiterpenes and sesquiterpene lactones Plasmodium falciparum [127]
Aspilia africana (Pers.) C. D. Adams Thiarubrine A Caenorhabditis elegans [128]
Baccharis retusa DC. Sakuranetin Leishmania sp. [40]
Baccharis uncinella DC. Caffeic acid Leishmania amazonensis [116]
Pectolinarigenin Leishmania braziliensis
Bidens pilosa L. Polyacetylene Plasmodium falciparum [63,151]
Bidens sulphurea (Cav.) Sch. Bip. 2,6-Di-tert-butyl-4-methylphenol, germacrene D, β-caryophyllene Schistosoma mansoni [1]
Calendula officinalis L. Glycosides of oleanolic acid Heligmosomoides polygyrus [145]
Centipeda minima (L.) A. Braun & Asch. Sesquiterpene lactone, brevilin A Giardia intestinalis [164]
    Entamoeba histolytica  
    Plasmodium falciparum  
Chromolaena odorata f. odorata Quercetin-4’-methyl ether Plasmodium falciparum [23]
Cichorium intybus L. Sesquiterpene lactone Haemonchus contortus [26]
Coreopsis lanceolate L. 1-Phenylhepta-1,3,5-triyne and 5-phenyl-2-(1’-propynyl)-thiophene Bursaphelenchus xylophilus and Caenorhabditis elegans [55]
Dicoma tomentosa Cass. Sesquiterpene lactones Plasmodium falciparum [48]
    3D7 and W2  
Dicoma anomala subsp. gerrardii (Harv. ex F. C. Wilson) S. Ortiz & Rodr. Oubiña Eudesmanolide-type sesquiterpene lactone Plasmodium falciparum D10 [38]
Eclipta prostrata (L.) L. Dasyscyphin C Leishmania major, [56]
    Leishmania aethiopica,  
    Leishmania tropica  
Elephantopus scaber L. Deoxyelephantopin Trypanosoma brucei rhodesience, strain STIB 900 [165]
Fructus arctii Arctigenin and arctiin Dactylogyrus intermedius [158]
Heterotheca inuloides Cass. 7-Hydroxy-3,4-dihydrocadalene, Giardia intestinalis [129]
  7-hydroxycalamenene    
Kleinia odora (Forssk.) DC. Ursolic acid and derivatives Plasmodium falciparum [89]
    Leishmania infantum  
    Trypanosoma cruzi  
    Trypanosoma brucei  
Pentacalia desiderabilis Cuatrec. Jacaranone Leishmania braziliensis [83]
    Leishmania amazonensis  
Porophyllum ruderale (Jacq.) Cass. Thiophene derivatives Leishmania amazonensis [146]
Sphaeranthus indicus L. Indicusalactone, (−)-oxyfrullanolide, 7-Hydroxyfrullanolide, squalene, 3,5-di-O-caffeoylquinic acid methyl ester, 3,4-di-O-caffeoylquinic acid methyl ester Plasmodium falciparum [132]
Tagetes erecta L. 2-Hydroxymethyl-non-3-ynoic acid, 2-[2,2’]-bithiophenyl-5- ethyl ester Plasmodium falciparum MRC-pf-2 [41]
Plasmodium falciparum MRC-pf-56
Tagetes patula L. Synonym of Tagetes erecta L. α-terthienyl, gallic and linoleic acids Heterodera zeae [24]
Tridax procumbens (L.) L. (3s)-16,17-Didehydrofalcarinol, Leishmania mexicana [75]
  (3S)-16,17-didehydrofalcarinol Leishmania mexicana [75]
Tanacetum parthenium (L.) Sch. Bip. Parthenolide Leishmania amazonensis [150]
Tithonia diversifolia (Hemsl.) A. Gray Sesquiterpenes and sesquiterpene lactones Plasmodium falciparum [38]
Trixis antimenorrhoea (Schrank) Mart. ex Baker Trixanolide Leishmania amazonensis [72]
    Leishmania braziliensis  
Vernonia amygdalina Delile Sesquiterpenes and sesquiterpene lactones Plasmodium falciparum [100]
Vernonia brachycalyx O. Hoffm. Sesquiterpene dilactone Plasmodium falciparum (K39, 3D7, V1/S and Dd2) [101]
Vernonia angulifolia DC. Sesquiterpenes and sesquiterpene lactones Plasmodium falciparum [121]
Xanthium macrocarpum DC. Xanthanolides (xanthinosin xanthatin, xanthinin, Leishmania mexicana [65]
  4-epiisoxanthanol, Leishmania infantum  
  4-epixanthanol)    
1

All taxonomic names were verified in the Global Composite Checklist database (http://compositae.landcareresearch.co.nz/Default.aspx)

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