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Review Article
Table 2
Therapeutic uses of important plants of the Asteraceae family reported as an antiparasitic
| Plant1 | Plant part used | Pharmacological | Preparation | Organism tested | Context of use | Reference |
|---|---|---|---|---|---|---|
| Acanthospermum hispidum DC. | Whole plant | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Aerial part | Antitrypanosomal | Dichloromethane/ Methanol/ Aqueous | Trypanosoma brucei brucei | In vitro | [10] | |
| Achyrocline flaccida (Weinm.) DC. | Whole plant | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Ageratina pentlandiana (DC.) R. M. King & H. Rob. | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | In vitro | [69] | ||||
| Ageratum conyzoides (L.) L. | Whole plant | Antiparasitic | Organic (hexane, ethyl acetate, chloroform, methanol) and aqueous extracts | Trypanosoma brucei Trypanosoma brucei rhodesiense Trypanosoma cruzi Leishmania donovani Plasmodium falciparum | In vitro | [98] |
| Whole plant | Chagas disease | Aqueous and ethanolic | Trypanosoma cruzi | In vitro | [149] | |
| Whole plant | Antileishmanial | Aqueous and ethanolic | Leishmania amazonensis | In vitro | [149] | |
| Leaf | Antiparasitic | Aqueous and ethanol extract | Heligmosomoides bakeri | In vitro | [157] | |
| Leaf | Antiparasitic | Ethanol extract | Rhipicephalus microplus | In vitro | [115] | |
| Artemisia absinthium L. | Flower | Antiparasitic | Di-ethyl ether essential oil | Toxocara cati | In vivo | [163] |
| Trypanosoma cruzi | In vitro | [74] | ||||
| Trichomonas vaginalis | ||||||
| Trypanosoma cruzi | In vitro | [5] | ||||
| Leishmania infantum | ||||||
| Leaf | Schistosomicidal | Dichloromethane | Schistosoma mansoni | In vitro | [20] | |
| Artemisia abyssinica Sch. Bip. ex A. Rich. | Aerial part | Antitrypanosomal | Dichloromethane: Methanol | Trypanosoma brucei brucei | In vitro | [94] |
| Dichloromethane | Trypanosoma congolense | In vivo | [25] | |||
| Aerial part | Antitrypanosomal | Dichloromethane: Methanol | Trypanosoma brucei brucei | In vitro | [94] | |
| Artemisia afra Jacq. ex Willd. | Leaf | Antitrypanosomal | Dichloromethane | Trypanosoma brucei rhodesiense / Trypanosoma cruzi. | In vitro | [82] |
| Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei brucei | In vitro | [94] | ||
| Antimalarial | Acetone | Plasmodium falciparum NF54 | In vitro | [85] | ||
| Artemisia annua L. | Aerial part | Antitrypanosomal | Dichloromethane: Methanol | Trypanosoma brucei brucei | In vitro | [94] |
| Artemisia herba-alba Asso | – | Antileishmanial | Aqueous | Leishmania tropica | In vitro | [43] |
| Baccharis salicifolia (Ruiz & Pav.) Pers. | Leaf | Antileishmanial | Ethyl acetate extract | Leishmania braziliensis | In vitro | [27] |
| Baccharis uncinella DC. | Leaf | Antileishmanial | Ursolic acid | Leishmania infantum | In vivo | [49] |
| Bidens pilosa L. | Leaf | Antimalarial | Organic extracts and fractions | Plasmodium falciparum | In vitro | [13] |
| Antimalarial | Organic extracts | Plasmodium falciparum | In vitro | [102] | ||
| Antimalarial | Organic extracts | Plasmodium falciparum | In vitro | [151] | ||
| Antimalarial | Organic extracts | Plasmodium falciparum, | in vitro & in vivo (mice) | [63] | ||
| Plasmodium berghei NK-65 | ||||||
| Anthelmintic | Ethanol extract | Haemonchus contortus | In vitro | [36] | ||
| Antileishmanial | Crude extracts | Leishmania amazonensis | In vitro | [35,49,151] | ||
| Blumea lacera (Burm.f.) DC. | Leaf | Anthelmintic | Alcoholic and aqueous extracts | Ascaris lumbricoides | In vitro | [119] |
| Pheretima posthuma | ||||||
| Calendula officinalis L. | Flower | Antileishmanial | Methanol (80%) | Leishmania major | In vitro | [95] |
| Antiparasitic | Oleanolic acid and its glycosides | Heligmosomoides polygyrus | in vitro & in vivo (mice) | [145] | ||
| Centipeda minima (L.) A. Braun & Asch. | Whole plant | Antiparasitic | Crude extracts and fractions | Giardia intestinalis | In vitro | [164] |
| Entamoeba histolytica | ||||||
| Plasmodium falciparum | ||||||
| Chersodoma jodopappa Cabrera | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania donovani | In vitro | [27] | |
| Cichorium intybus L. | Leaf | Anthelmintic | Methanol:water | Ascaris suum | In vitro | [160] |
| Oesophagostomum dentatum | ||||||
| Cnicothamnus lorentzii Griseb. | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania donovani | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania braziliensis | In vitro | [27] | |
| Conyza albida Willd. ex Spreng. | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, Trypanosoma cruzi | In vitro | [82] |
| Conyza podocephala DC. | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Conyza scabrida DC. | Leaf | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Echinacea purpurea (L.) Moench | Whole part | Antileishmanial | Ethanol extract | Leishmania sp. | In vitro | [114] |
| Eclipta alba (L.) Hassk. | Leaf | Antimalarial | Crude extract | Plasmodium berghei | In vivo | [6] |
| Antileishmanial | Crude extract | Leishmania donovani | In vitro | [138] | ||
| Eclipta prostrata (L.) L. | Leaf | Anthelmintic activity | Ethanol and aqueous extracts | Pheretima posthuma | In vitro | [11] |
| Leaf | Anthelmintic activity | Organic extracts | Pheretima posthuma | In vitro | [50] | |
| Leaf | Antileishmanial | Saponin, dasyscyphin C | Leishmania major, | In vitro | [56] | |
| Leishmania aethiopica, | ||||||
| Leishmania tropica | ||||||
| Whole plant | Anthelmintic activity | Organic and water extracts | Haemonchus contortus | In vitro | [139] | |
| Elephantopus scaber L. | Leaf | Antitrypanosomal | Organic extracts and sesquiterpene lactone | Trypanosoma brucei rhodesiense | In vitro | [165] |
| Helichrysum nudifolium (L.) Less. | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Inula montana L. | Aerial part | Antileishmanial | Methanol | Leishmania infantum | In vitro | [73] |
| Jasonia glutinosa (L.) DC. | Aerial part | Antileishmanial | Acetone | Leishmania donovani | In vitro | [156] |
| Kleinia odora (Forssk.) DC. | Whole plant | Antiparasitic | Ursane, triterpenes of lupane | Trypanosoma brucei | In vitro | [89] |
| Trypanosoma cruzi | ||||||
| Leishmania infantum | ||||||
| Plasmodium falciparum | ||||||
| Munnozia fournetii H. Rob. (unresolved name) | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania donovani | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania braziliensis | In vitro | [27] | |
| Neurolaena lobate (L.) R.Br. ex Cass. | Leaf | Antileishmanial | Ethanol extract | Leishmania mexicana | In vitro | [9] |
| Leishmania braziliensis | ||||||
| Oedera genistifolia (L.) Anderb. & K.Bremer | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, Trypanosoma cruzi | In vitro | [82] |
| Ophryosporus piquerioides (DC.) Benth. ex Baker | Whole plant | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Pentzia globosa Less. | Root | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense /Trypanosoma cruzi | In vitro | [82] |
| Perezia multiflora (Humb. & Bonpl.) Less. | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Leishmania donovani | ||||||
| Pterocaulon alopecuroideum Chodat (unresolved name) | Whole plant | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Leishmania donovani | ||||||
| Senecio clivicolus Wedd. | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania donovani | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania braziliensis | In vitro | [27] | |
| Solanecio mannii (Hook. F) C. Jeffrey | Leaf | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei brucei | In vitro | [94] |
| Sphaeranthus indicus L. | Whole plant | Anthelmintic | Ethanolic and aqueous extracts | Pheretima posthuma, | In vitro | [134] |
| Ascaridia galli | ||||||
| Leaf | Macrofilaricidal activity | Methanolic | Setaria digitata | In vitro | [96] | |
| Stevia yaconensis Hieron. | Whole plant | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Leishmania donovani | ||||||
| Tagetes erecta L. | Root | Antimalarial | Organic and aqueous extracts | Plasmodium falciparum | In vitro | [41] |
| Flower | Anthelmintic | Organic extracts | Pheretima posthuma | In vitro | [106] | |
| Tithonia diversifolia (Hemsl.) A. Gray | Leaf | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei brucei | In vivo | [103] |
| Tridax procumbens (L.) L. | Whole plant | Antileishmanial property | Organic extracts and (3S)-16,17 didehydrofalcarinol | Leishmania mexicana | In vitro | [75] |
| Methanol extract and in combination with Allium sativum | Leishmania mexicana | In vivo | [33] | |||
| Oxylipin, (3S)-16,17-didehydrofalcarinol | Leishmania mexicana | In vitro | [75] | |||
| Vernonia anthelmintica (L.) Willd. |
Whole plant | Anthelmintic | Aqueous and methanolic extracts | Haemonchus contortus | in vitro & in vivo | [45] |
| Seed | Anthelmintic | Ethanolic extract | Haemonchus contortus | In vitro | [44] | |
| Seed | Anthelmintic | – | Haemonchus contortus | In vivo (buffaloes) | [93] | |
| Vernonia auriculifera Hiern | Root | Antitrypanosomal | Dichloromethane | Trypanosoma brucei rhodesiense | In vitro | [29] |
| Vernonia hirsute (DC.) Sch. Bip. ex Walp. | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Vernonia mespilifolia Less. | Leaf | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Vernonia natalensis Oliv. & Hiern | Whole plant | Antitrypanosomal | Dichloromethane: methanol | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Vernonia oligocephala Katt | Leaf | Antitrypanosomal | Dichloromethane | Trypanosoma brucei rhodesiense, | In vitro | [82] |
| Trypanosoma cruzi | ||||||
| Vernonia squamulose Hook. & Arn. | Stem | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania braziliensis | ||||||
| Leishmania donovani | ||||||
| Werneria nubigena Kunth | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania donovani | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania braziliensis | In vitro | [27] | |
| Xanthium catharticum Kunth | Leaf | Antileishmanial | Ethanol extract | Leishmania amazonensis | In vitro | [27] |
| Leishmania donovani | ||||||
| Stem | Antileishmanial | Ethanol extract | Leishmania braziliensis | In vitro | [27] | |
| Xanthium strumarium L. | Leaf | Antitrypanosomal | 50% ethanolic extract | Trypanosoma evansi | In vitro and in vivo | [147] |
| Fruit | Antimalarial | Methanol: water extract | Plasmodium falciparum strain FCR-3 | In vitro | [153] | |
1
All taxonomic names were verified in the Global Composite Checklist database (http://compositae.landcareresearch.co.nz/Default.aspx)
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