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Table 2

Therapeutic uses of important plants of the Asteraceae family reported as an antiparasitic

Plant1 Plant part used Pharmacological Preparation Organism tested Context of use Reference
Acanthospermum hispidum DC. Whole plant Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
  Aerial part Antitrypanosomal Dichloromethane/ Methanol/ Aqueous Trypanosoma brucei brucei In vitro [10]
Achyrocline flaccida (Weinm.) DC. Whole plant Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
Ageratina pentlandiana (DC.) R. M. King & H. Rob. Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis In vitro [69]
Ageratum conyzoides (L.) L. Whole plant Antiparasitic Organic (hexane, ethyl acetate, chloroform, methanol) and aqueous extracts Trypanosoma brucei Trypanosoma brucei rhodesiense Trypanosoma cruzi Leishmania donovani Plasmodium falciparum In vitro [98]
  Whole plant Chagas disease Aqueous and ethanolic Trypanosoma cruzi In vitro [149]
  Whole plant Antileishmanial Aqueous and ethanolic Leishmania amazonensis In vitro [149]
  Leaf Antiparasitic Aqueous and ethanol extract Heligmosomoides bakeri In vitro [157]
  Leaf Antiparasitic Ethanol extract Rhipicephalus microplus In vitro [115]
Artemisia absinthium L. Flower Antiparasitic Di-ethyl ether essential oil Toxocara cati In vivo [163]
        Trypanosoma cruzi In vitro [74]
        Trichomonas vaginalis    
        Trypanosoma cruzi In vitro [5]
        Leishmania infantum    
  Leaf Schistosomicidal Dichloromethane Schistosoma mansoni In vitro [20]
Artemisia abyssinica Sch. Bip. ex A. Rich. Aerial part Antitrypanosomal Dichloromethane: Methanol Trypanosoma brucei brucei In vitro [94]
      Dichloromethane Trypanosoma congolense In vivo [25]
  Aerial part Antitrypanosomal Dichloromethane: Methanol Trypanosoma brucei brucei In vitro [94]
Artemisia afra Jacq. ex Willd. Leaf Antitrypanosomal Dichloromethane Trypanosoma brucei rhodesiense / Trypanosoma cruzi. In vitro [82]
    Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei brucei In vitro [94]
    Antimalarial Acetone Plasmodium falciparum NF54 In vitro [85]
Artemisia annua L. Aerial part Antitrypanosomal Dichloromethane: Methanol Trypanosoma brucei brucei In vitro [94]
Artemisia herba-alba Asso Antileishmanial Aqueous Leishmania tropica In vitro [43]
Baccharis salicifolia (Ruiz & Pav.) Pers. Leaf Antileishmanial Ethyl acetate extract Leishmania braziliensis In vitro [27]
Baccharis uncinella DC. Leaf Antileishmanial Ursolic acid Leishmania infantum In vivo [49]
Bidens pilosa L. Leaf Antimalarial Organic extracts and fractions Plasmodium falciparum In vitro [13]
    Antimalarial Organic extracts Plasmodium falciparum In vitro [102]
    Antimalarial Organic extracts Plasmodium falciparum In vitro [151]
    Antimalarial Organic extracts Plasmodium falciparum, in vitro & in vivo (mice) [63]
        Plasmodium berghei NK-65    
    Anthelmintic Ethanol extract Haemonchus contortus In vitro [36]
    Antileishmanial Crude extracts Leishmania amazonensis In vitro [35,49,151]
Blumea lacera (Burm.f.) DC. Leaf Anthelmintic Alcoholic and aqueous extracts Ascaris lumbricoides In vitro [119]
        Pheretima posthuma    
Calendula officinalis L. Flower Antileishmanial Methanol (80%) Leishmania major In vitro [95]
    Antiparasitic Oleanolic acid and its glycosides Heligmosomoides polygyrus in vitro & in vivo (mice) [145]
Centipeda minima (L.) A. Braun & Asch. Whole plant Antiparasitic Crude extracts and fractions Giardia intestinalis In vitro [164]
        Entamoeba histolytica    
        Plasmodium falciparum    
Chersodoma jodopappa Cabrera Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
  Stem Antileishmanial Ethanol extract Leishmania donovani In vitro [27]
Cichorium intybus L. Leaf Anthelmintic Methanol:water Ascaris suum In vitro [160]
        Oesophagostomum dentatum    
Cnicothamnus lorentzii Griseb. Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania donovani    
  Stem Antileishmanial Ethanol extract Leishmania braziliensis In vitro [27]
Conyza albida Willd. ex Spreng. Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, Trypanosoma cruzi In vitro [82]
Conyza podocephala DC. Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Conyza scabrida DC. Leaf Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Echinacea purpurea (L.) Moench Whole part Antileishmanial Ethanol extract Leishmania sp. In vitro [114]
Eclipta alba (L.) Hassk. Leaf Antimalarial Crude extract Plasmodium berghei In vivo [6]
    Antileishmanial Crude extract Leishmania donovani In vitro [138]
Eclipta prostrata (L.) L. Leaf Anthelmintic activity Ethanol and aqueous extracts Pheretima posthuma In vitro [11]
  Leaf Anthelmintic activity Organic extracts Pheretima posthuma In vitro [50]
  Leaf Antileishmanial Saponin, dasyscyphin C Leishmania major, In vitro [56]
        Leishmania aethiopica,    
        Leishmania tropica    
  Whole plant Anthelmintic activity Organic and water extracts Haemonchus contortus In vitro [139]
Elephantopus scaber L. Leaf Antitrypanosomal Organic extracts and sesquiterpene lactone Trypanosoma brucei rhodesiense In vitro [165]
Helichrysum nudifolium (L.) Less. Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Inula montana L. Aerial part Antileishmanial Methanol Leishmania infantum In vitro [73]
Jasonia glutinosa (L.) DC. Aerial part Antileishmanial Acetone Leishmania donovani In vitro [156]
Kleinia odora (Forssk.) DC. Whole plant Antiparasitic Ursane, triterpenes of lupane Trypanosoma brucei In vitro [89]
        Trypanosoma cruzi    
Leishmania infantum
        Plasmodium falciparum    
Munnozia fournetii H. Rob. (unresolved name) Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania donovani    
  Stem Antileishmanial Ethanol extract Leishmania braziliensis In vitro [27]
Neurolaena lobate (L.) R.Br. ex Cass. Leaf Antileishmanial Ethanol extract Leishmania mexicana In vitro [9]
        Leishmania braziliensis    
Oedera genistifolia (L.) Anderb. & K.Bremer Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, Trypanosoma cruzi In vitro [82]
Ophryosporus piquerioides (DC.) Benth. ex Baker Whole plant Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
Pentzia globosa Less. Root Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense /Trypanosoma cruzi In vitro [82]
Perezia multiflora (Humb. & Bonpl.) Less. Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
        Leishmania donovani    
Pterocaulon alopecuroideum Chodat (unresolved name) Whole plant Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
        Leishmania donovani    
Senecio clivicolus Wedd. Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania donovani    
  Stem Antileishmanial Ethanol extract Leishmania braziliensis In vitro [27]
Solanecio mannii (Hook. F) C. Jeffrey Leaf Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei brucei In vitro [94]
Sphaeranthus indicus L. Whole plant Anthelmintic Ethanolic and aqueous extracts Pheretima posthuma, In vitro [134]
        Ascaridia galli    
  Leaf Macrofilaricidal activity Methanolic Setaria digitata In vitro [96]
Stevia yaconensis Hieron. Whole plant Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
        Leishmania donovani    
Tagetes erecta L. Root Antimalarial Organic and aqueous extracts Plasmodium falciparum In vitro [41]
  Flower Anthelmintic Organic extracts Pheretima posthuma In vitro [106]
Tithonia diversifolia (Hemsl.) A. Gray Leaf Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei brucei In vivo [103]
Tridax procumbens (L.) L. Whole plant Antileishmanial property Organic extracts and (3S)-16,17 didehydrofalcarinol Leishmania mexicana In vitro [75]
      Methanol extract and in combination with Allium sativum Leishmania mexicana In vivo [33]
      Oxylipin, (3S)-16,17-didehydrofalcarinol Leishmania mexicana In vitro [75]
Vernonia anthelmintica (L.)
Willd.
Whole plant Anthelmintic Aqueous and methanolic extracts Haemonchus contortus in vitro & in vivo [45]
  Seed Anthelmintic Ethanolic extract Haemonchus contortus In vitro [44]
  Seed Anthelmintic Haemonchus contortus In vivo (buffaloes) [93]
Vernonia auriculifera Hiern Root Antitrypanosomal Dichloromethane Trypanosoma brucei rhodesiense In vitro [29]
Vernonia hirsute (DC.) Sch. Bip. ex Walp. Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Vernonia mespilifolia Less. Leaf Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Vernonia natalensis Oliv. & Hiern Whole plant Antitrypanosomal Dichloromethane: methanol Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Vernonia oligocephala Katt Leaf Antitrypanosomal Dichloromethane Trypanosoma brucei rhodesiense, In vitro [82]
        Trypanosoma cruzi    
Vernonia squamulose Hook. & Arn. Stem Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania braziliensis    
        Leishmania donovani    
Werneria nubigena Kunth Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania donovani    
  Stem Antileishmanial Ethanol extract Leishmania braziliensis In vitro [27]
Xanthium catharticum Kunth Leaf Antileishmanial Ethanol extract Leishmania amazonensis In vitro [27]
        Leishmania donovani    
  Stem Antileishmanial Ethanol extract Leishmania braziliensis In vitro [27]
Xanthium strumarium L. Leaf Antitrypanosomal 50% ethanolic extract Trypanosoma evansi In vitro and in vivo [147]
  Fruit Antimalarial Methanol: water extract Plasmodium falciparum strain FCR-3 In vitro [153]
1

All taxonomic names were verified in the Global Composite Checklist database (http://compositae.landcareresearch.co.nz/Default.aspx)

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