Pathogenesis of Plasmodium berghei ANKA infection in the gerbil (Meriones unguiculatus) as an experimental model for severe malaria

Quazim Olawale Junaid; Loke Tim Khaw; Rohela Mahmud; Kien Chai Ong; Yee Ling Lau; Prajakta Uttam Borade; Jonathan Wee Kent Liew; Sinnadurai Sivanandam; Kum Thong Wong; Indra Vythilingam

doi:10.1051/parasite/2017040

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Volume 24 (2017)

Parasite, 24 (2017) 38

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Research Article

Table 2

Clinical symptoms observed in infected gerbils (n = 30).

Symptoms	Concentrations of pRBCs						Total N (%)

	10⁷	10⁶	10⁵	10⁴	10³	10²
Ruffled hair	5	4	4	4	5	3	25 (83.3)
Hunchback	2	3	4	3	4	4	20 (66.7)
Ataxia	0	0	0	0	0	0	0 (0.0)
Convulsion	0	0	0	0	0	0	0 (0.0)
Wobbly gait	1	2	3	2	1	2	11 (36.7)
Deviation of the head	0	0	0	0	0	0	0 (0.0)
Paralysis	0	0	0	1	0	0	1 (3.3)^*

Gerbils were observed daily to monitor their clinical symptoms. Five gerbils were assessed in each group.

^*

The gerbil showed partial paralysis of the hind limbs briefly before death. pRBCs: parasitized red blood cells.

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