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Table 1.

Important characteristics for the differential diagnosis of Acanthamoeba keratitis (AK) compared to keratitis due to other infectious agents.

Specific characteristics of AK When compared to
Pseudo-dendritiform epitheliopathy, epithelium defects without terminal knots, perineural infiltrates, [ring infiltrate]*, endothelium is not involved Herpes simplex keratitis
Usually restricted to cornea, absence of anterior chamber activity, stromal infiltrates are usually multifocal (not monofocal), [ring infiltrate]* Bacterial keratitis
Usually restricted to cornea, clear epithelium defects, perineural stromal infiltrates, [ring infiltrate]* Fungal keratitis

The characteristic ring infiltrate is only seen in the advanced stage and even then only in 50% of patients.

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