Open Access
Volume 22, 2015
Article Number 10
Number of page(s) 20
Published online 18 February 2015
  1. Abdulhalim B, Wagih MM, Gad AA, Boghdadi G, Nagy RR. 2015. Amniotic membrane graft to conjunctival flap in treatment of non-viral resistant infectious keratitis: a randomised clinical study. British Journal of Ophthalmology, 99(1), 59–63. [CrossRef] [Google Scholar]
  2. Aichelburg AC, Walochnik J, Assadian O, Prosch H, Steuer A, Perneczky G, Visvesvara GS, Aspöck H, Vetter N. 2008. Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine. Emerging Infectious Diseases, 14, 1743–1746. [CrossRef] [PubMed] [Google Scholar]
  3. Alsam S, Sissons J, Dudley R, Khan NA. 2005. Mechanisms associated with Acanthamoeba castellanii (T4) phagocytosis. Parasitology Research, 96, 402–409. [CrossRef] [PubMed] [Google Scholar]
  4. Aqeel Y, Siddiqui R, Khan NA. 2013. Silencing of xylose isomerase and cellulose synthase by siRNA inhibits encystation in Acanthamoeba castellanii. Parasitology Research, 112(3), 1221–1227. [CrossRef] [PubMed] [Google Scholar]
  5. Arnalich-Montiel F, Martín-Navarro CM, Alió JL, López-Vélez R, Martínez-Carretero E, Valladares B, Piñero JE, Lorenzo-Morales J. 2012. Successful monitoring and treatment of intraocular dissemination of Acanthamoeba with voriconazole. Archives of Ophthalmology, 130, 1474–1475. [CrossRef] [PubMed] [Google Scholar]
  6. Bacon AS, Frazer DG, Dart JK, Matheson M, Ficker LA, Wright P. 1993. A review of 72 consecutive cases of Acanthamoeba keratitis, 1984–1992. Eye, 7, 719–725. [CrossRef] [Google Scholar]
  7. Bagorda A, Parent CA. 2008. Eukaryotic chemotaxis at a glance. Journal of Cell Science, 121, 2621–2624. [CrossRef] [PubMed] [Google Scholar]
  8. Barisani-Asenbauer T, Walochnik J, Mejdoubi L, Binder S. 2012. Successful management of recurrent Acanthamoeba keratitis using topical and systemic miltefosine. Acta Ophthalmologica, 900, doi: 10.1111/j.1755-3768.2012.F095.x. [Google Scholar]
  9. Beattie TK, Tomlinson A, McFadyen AK, Seal DV, Grimason AM. 2003. Enhanced attachment of Acanthamoeba to extended-wear silicone hydrogel contact lenses: a new risk factor for infection? Ophthalmology, 110, 765–771. [CrossRef] [PubMed] [Google Scholar]
  10. Blackman HJ, Rao NA, Lemp MA, Visvesvara GS. 1984. Acanthamoeba keratitis successfully treated with penetrating keratoplasty: suggested immunogenic mechanisms of action. Cornea, 3, 125. [CrossRef] [PubMed] [Google Scholar]
  11. Booton GC, Joslin CE, Shoff M, Tu EY, Kelly DJ, Fuerst PA. 2009. Genotypic identification of Acanthamoeba sp. isolates associated with an outbreak of Acanthamoeba keratitis. Cornea, 28(6), 673–676. [CrossRef] [PubMed] [Google Scholar]
  12. Bouheraoua N, Gaujoux T, Goldschmidt P, Chaumeil C, Laroche L, Borderie VM. 2013. Prognostic factors associated with the need for surgery in Acanthamoeba keratitis. Cornea, 32, 130–136. [CrossRef] [PubMed] [Google Scholar]
  13. Brooks SE, Schneider DL. 1985. Oxidative metabolism associated with phagocytosis in Acanthamoeba castellanii. Journal of Protozoology, 32, 330–333. [CrossRef] [Google Scholar]
  14. Campochiaro PA. 2006. Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders. Gene Therapy, 13, 559–562. [CrossRef] [PubMed] [Google Scholar]
  15. Cho JH, Na BK, Kim TS, Song CY. 2000. Purification and characterization of an extracellular serine proteinase from Acanthamoeba castellanii. IUBMB Life, 50, 209–214. [CrossRef] [PubMed] [Google Scholar]
  16. Chusattayanond AD, Boonsilp S, Kasisit J, Boonmee A, Warit S. 2010. Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway. Parasitology International, 59, 512–516. [CrossRef] [PubMed] [Google Scholar]
  17. Clarke DW, Niederkorn JY. 2006. The immunobiology of Acanthamoeba keratitis. Microbes and Infection, 8(5), 1400–1405. [CrossRef] [Google Scholar]
  18. Clarke DW, Niederkorn JY. 2006. The pathophysiology of Acanthamoeba keratitis. Trends in Parasitology, 22(4), 175–180. [CrossRef] [PubMed] [Google Scholar]
  19. Clarke M, Lohan AJ, Liu B, Lagkouvardos I, Roy S, Zafar N, Bertelli C, Schilde C, Kianianmomeni A, Bürglin TR, Frech C, Turcotte B, Kopec KO, Synnott JM, Choo C, Paponov I, Finkler A, Heng Tan CS, Hutchins AP, Weinmeier T, Rattei T, Chu JS, Gimenez G, Irimia M, Rigden DJ, Fitzpatrick DA, Lorenzo-Morales J, Bateman A, Chiu CH, Tang P, Hegemann P, Fromm H, Raoult D, Greub G, Miranda-Saavedra D, Chen N, Nash P, Ginger ML, Horn M, Schaap P, Caler L, Loftus BJ. 2013. Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. Genome Biology, 14(2), R11. [CrossRef] [PubMed] [Google Scholar]
  20. Cohen EJ, Buchanan HW, Laughrea PA, Adams CP, Galentine PG, Visvesvara GS, Folberg R, Arentsen JJ, Laibson PR. 1985. Diagnosis and management of Acanthamoeba keratitis. American Journal of Ophthalmology, 100(3), 389–395. [CrossRef] [PubMed] [Google Scholar]
  21. Cohen EJ, Parlato CJ, Arentsen JJ, Genvert GI, Eagle RC Jr, Wieland MR, Laibson PR. 1987. Medical and surgical treatment of Acanthamoeba keratitis. American Journal of Ophthalmology, 103(5), 615–625. [CrossRef] [PubMed] [Google Scholar]
  22. Cursons RTM, Brown TJ. 1978. Use of cell cultures as an indicator of pathogenicity of free-living amoebae. Journal of Clinical Pathology, 31, 1–11. [CrossRef] [PubMed] [Google Scholar]
  23. Dart JK, Saw VP, Kilvington S. 2009. Acanthamoeba keratitis: diagnosis and treatment update 2009. American Journal of Ophthalmology, 148(4), 487–499. [CrossRef] [PubMed] [Google Scholar]
  24. De Jonckheere JF. 1980. Growth characteristics, cytopathic effect in cell culture, and virulence in mice of 36 type strains belonging to 19 different Acanthamoeba spp. Applied and Environmental Microbiology, 39(4), 681–685. [PubMed] [Google Scholar]
  25. Del Buey MA, Cristóbal JA, Casas P, Goñi P, Clavel A, Mínguez E, Lanchares E, García A, Calvo B. 2012. Evaluation of in vitro efficacy of combined riboflavin and ultraviolet a for Acanthamoeba isolates. American Journal of Ophthalmology, 153(3), 399–404. [CrossRef] [PubMed] [Google Scholar]
  26. Diaz J, Osuna A, Rosales MJ, Cifuentes J, Mascaro C. 1991. Sucker-like structures in two strains of Acanthamoeba: scanning electron microscopy study. International Journal of Parasitology, 21, 365–367. [CrossRef] [Google Scholar]
  27. Dudley R, Alsam S, Khan NA. 2007. Cellulose biosynthesis pathway is a potential target in the improved treatment of Acanthamoeba keratitis. Applied Microbiology and Biotechnology, 75(1), 133–140. [CrossRef] [PubMed] [Google Scholar]
  28. Ferreira GA, Magliano AC, Pral EM, Alfieri SC. 2009. Elastase secretion in Acanthamoeba polyphaga. Acta Tropica, 112, 156–163. [CrossRef] [PubMed] [Google Scholar]
  29. Ficker L, Seal D, Warhurst D, Wright P. 1990. Acanthamoeba keratitis-resistance to medical therapy. Eye, 4, 835–838. [CrossRef] [Google Scholar]
  30. Garate M, Cao Z, Bateman E, Panjwani N. 2004. Cloning and characterization of a novel mannose-binding protein of Acanthamoeba. Journal of Biological Chemistry, 279, 29849–29856. [CrossRef] [Google Scholar]
  31. Garate M, Cubillos I, Marchant J, Panjwani N. 2005. Biochemical characterization and functional studies of Acanthamoeba mannose-binding protein. Infection and Immunity, 73, 5775–5781. [CrossRef] [PubMed] [Google Scholar]
  32. Garduño-Vieyra L, González-Sánchez CR, Hernández-Da Mota SE. 2011. Ultraviolet-a light and riboflavin therapy for Acanthamoeba keratitis: a case report. Case Reports in Ophthalmology, 2(2), 291–295. [PubMed] [Google Scholar]
  33. Gast RJ, Ledee DR, Fuerst PA, Byers T. 1996. Subgenus systematics of Acanthamoeba: Four nuclear 18S rDNA sequence types. Journal of Eukaryotic Microbiology, 43, 498–504. [CrossRef] [Google Scholar]
  34. Griffin JL. 1972. Temperature tolerance of pathogenic and nonpathogenic free-living amoebae. Science, 178, 869–870. [CrossRef] [PubMed] [Google Scholar]
  35. Grossniklaus HE, Waring GO 4th, Akor C, Castellano-Sanchez AA, Bennett K. 2003. Evaluation of hematoxylin and eosin and special stains for the detection of Acanthamoeba keratitis in penetrating keratoplasties. American Journal of Ophthalmology, 136(3), 520–526. [CrossRef] [PubMed] [Google Scholar]
  36. Hamburg A, De Jonckheere JF. 1980. Amoebic keratitis. Ophthalmologica, 181, 74. [CrossRef] [PubMed] [Google Scholar]
  37. He YG, Niederkorn JY, McCulley JP, Stewart GL, Meyer DR, Silvany R, Dougherty J. 1990. In vivo and in vitro collagenolytic activity of Acanthamoeba castellanii. Investigative Ophthalmology and Visual Science, 31, 2235–2240. [Google Scholar]
  38. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G. 1995. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proceedings of the National Academy of Science USA, 92(15), 7090–7094. [CrossRef] [Google Scholar]
  39. Henrissat B, Davies G. 1995. Structures and mechanisms of glycosyl hydrolases. Structure, 3(9), 853–859. [CrossRef] [PubMed] [Google Scholar]
  40. Hong YC, Lee WM, Kong HH, Jeong HJ, Chung DI. 2004. Molecular cloning and characterization of a cDNA encoding a laminin-binding protein (AhLBP) from Acanthamoeba healyi. Experimental Parasitology, 106, 95–102. [CrossRef] [PubMed] [Google Scholar]
  41. Ikeda Y, Miyazaki D, Yakura K, Kawaguchi A, Ishikura R, Inoue Y, Mito T, Shiraishi A, Ohashi Y, Higaki S, Itahashi M, Fukuda M, Shimomura Y, Yagita K. 2012. Assessment of real-time polymerase chain reaction detection of Acanthamoeba and prognosis determinants of Acanthamoeba keratitis. Ophthalmology, 119, 1111–1119. [CrossRef] [PubMed] [Google Scholar]
  42. Im K. 1990. Pathogenic free-living amoebae. Korean Journal of Parasitology, 28, 29–39. [CrossRef] [Google Scholar]
  43. Kao PM, Tung MC, Hsu BM, Tsai HL, She CY, Shen SM, Huang WC. 2013. Real-time PCR method for the detection and quantification of Acanthamoeba species in various types of water samples. Parasitology Research, 112(3), 1131–1136. [CrossRef] [PubMed] [Google Scholar]
  44. Kandori M, Inoue T, Shimabukuro M, Hayashi H, Hori Y, Maeda N, Tano Y. 2010. Four cases of Acanthamoeba keratitis treated with phototherapeutic keratectomy. Cornea, 29(10), 1199–1202. [CrossRef] [PubMed] [Google Scholar]
  45. Kashiwabuchi RT, Carvalho FR, Khan YA, de Freitas D, Foronda AS, Hirai FE, Campos MS, McDonnell PJ. 2011. Assessing efficacy of combined riboflavin and UV-A light (365 nm) treatment of Acanthamoeba trophozoites. Investigative Ophthalmology and Visual Science, 52(13), 9333–9338. [CrossRef] [Google Scholar]
  46. Khan NA. 2009. Acanthamoeba – Biology and Pathogenesis. Caister Academic Press: Norfolk, Great Britain, 290 p. [Google Scholar]
  47. Khan NA. 2006. Acanthamoeba: biology and increasing importance in human health. FEMS Microbiology Reviews, 30, 564–595. [CrossRef] [PubMed] [Google Scholar]
  48. Khan NA. 2001. Pathogenicity, morphology and differentiation of Acanthamoeba. Current Microbiology, 43, 391–395. [CrossRef] [PubMed] [Google Scholar]
  49. Khan YA, Kashiwabuchi RT, Martins SA, Castro-Combs JM, Kalyani S, Stanley P, Flikier D, Behrens A. 2011. Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis: report of 3 cases. Ophthalmology, 118(2), 324–331. [CrossRef] [PubMed] [Google Scholar]
  50. Kim JY, Na BK, Song KJ, Park MH, Park YK, Kim TS. 2012. Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii. Parasitology Research, 111, 1673–1682. [CrossRef] [PubMed] [Google Scholar]
  51. Kitzmann AS, Goins KM, Sutphin JE, Wagoner MD. 2009. Keratoplasty for treatment of Acanthamoeba keratitis. Ophthalmology, 116, 864–869. [CrossRef] [PubMed] [Google Scholar]
  52. Lim N, Goh D, Bunce C, Xing W, Fraenkel G, Poole TR, Ficker L. 2008. Comparison of polyhexamethylene biguanide and chlorhexidine as monotherapy agents in the treatment of Acanthamoeba keratitis. American Journal of Ophthalmology, 145, 130–135. [CrossRef] [PubMed] [Google Scholar]
  53. Lorenzo-Morales J, Kliescikova J, Martínez-Carretero E, De Pablos LM, Profotova B, Nohynkova E, Osuna A, Valladares B. 2008. Glycogen phosphorylase in Acanthamoeba spp.: determining the role of the enzyme during the encystment process using RNA interference. Eukaryotic Cell, 7(3), 509–517. [CrossRef] [PubMed] [Google Scholar]
  54. Lorenzo-Morales J, Martín-Navarro CM, López-Arencibia A, Arnalich-Montiel F, Piñero JE, Valladares B. 2013. Acanthamoeba keratitis: an emerging disease gathering importance worldwide? Trends in Parasitology, 29(4), 181–187. [CrossRef] [PubMed] [Google Scholar]
  55. Lorenzo-Morales J, Ortega-Rivas A, Foronda P, Abreu-Acosta N, Ballart D, Martínez E, Valladares B. 2005. RNA interference (RNAi) for the silencing of extracellular serine proteases genes in Acanthamoeba: Molecular analysis and effect on pathogenecity. Molecular and Biochemical Parasitology, 144, 10–15. [CrossRef] [PubMed] [Google Scholar]
  56. Marciano-Cabral F, Cabral G. 2003. Acanthamoeba spp. as agents of disease in humans. Clinical Microbiology Reviews, 16(2), 273–307. [Google Scholar]
  57. Martín-Navarro CM, Lorenzo-Morales J, López-Arencibia A, Reyes-Batlle M, Piñero JE, Valladares B, Maciver SK. 2014. Evaluation of Acanthamoeba myosin-IC as a potential therapeutic target. Antimicrobial Agents and Chemotherapy, 58(4), 2150–2155. [CrossRef] [PubMed] [Google Scholar]
  58. Martín-Navarro CM, Lorenzo-Morales J, Machin RP, López-Arencibia A, García-Castellano JM, de Fuentes I, Loftus B, Maciver SK, Valladares B, Piñero JE. 2013. Inhibition of HMG-CoA reductase and the application of statins as a novel effective therapeutic approach against Acanthamoeba infections. Antimicrobial Agents and Chemotherapy, 57(1), 375–381. [CrossRef] [PubMed] [Google Scholar]
  59. Mathers WD, Nelson SE, Lane JL, Wilson ME, Allen RC, Folberg R. 2000. Confirmation of confocal microscopy diagnosis of Acanthamoeba keratitis using polymerase chain reaction analysis. Archives of Ophthalmology, 118, 178–183. [CrossRef] [PubMed] [Google Scholar]
  60. Mattana A, Cappai V, Alberti L, Serra C, Fiori PL, Cappuccinelli P. 2002. ADP and other metabolites released from Acanthamoeba castellanii lead to human monocytic cell death through apoptosis and stimulate the secretion of proinflammatory cytokines. Infection and Immunity, 70, 4424–4432. [CrossRef] [PubMed] [Google Scholar]
  61. Maubon D, Dubosson M, Chiquet C, Yera H, Brenier-Pinchart MP, Cornet M, Savy O, Renard E, Pelloux H. 2012. A one-step multiplex PCR for Acanthamoeba keratitis diagnosis and quality samples control. Investigative Ophthalmology and Visual Science, 53(6), 2866–2872. [CrossRef] [Google Scholar]
  62. Mazur T, Hadas E, Iwanicka I. 1995. The duration of the cyst stage and the viability and virulence of Acanthamoeba isolates. Tropical Medicine and Parasitology, 46, 106–108. [Google Scholar]
  63. McClellan K, Howard K, Niederkorn JY, Alizadeh H. 2001. Effect of steroids on Acanthamoeba cysts and trophozoites. Investigative Ophthalmology and Visual Science, 42, 2885–2893. [Google Scholar]
  64. Michalek M, Sönnichsen FD, Wechselberger R, Dingley AJ, Hung CW, Kopp A, Wienk H, Simanski M, Herbst R, Lorenzen I, Marciano-Cabral F, Gelhaus C, Gutsmann T, Tholey A, Grötzinger J, Leippe M. 2013. Structure and function of a unique pore-forming protein from a pathogenic Acanthamoeba. Nature Chemical Biology, 9, 37–42. [CrossRef] [PubMed] [Google Scholar]
  65. Moon EK, Hong Y, Chung DI, Goo YK, Kong HH. 2014. Down-regulation of cellulose synthase inhibits the formation of endocysts in Acanthamoeba. Korean Journal of Parasitology, 52(2), 131–135. [CrossRef] [Google Scholar]
  66. Mortazavi PN, Keisary E, Loh LN, Jung SY, Khan NA. 2011. Possible roles of phospholipase A2 in the biological activities of Acanthamoeba castellanii (T4 genotype). Protist, 162, 168–176. [CrossRef] [PubMed] [Google Scholar]
  67. Na BK, Cho JH, Song CY, Kim TS. 2002. Degradation of immunoglobulins, protease inhibitors and interleukin-1 by a secretory proteinase of Acanthamoeba castellanii. Korean Journal of Parasitology, 40, 93–99. [CrossRef] [Google Scholar]
  68. Na BK, Kim JC, Song CY. 2001. Characterization and pathogenetic role of proteinase from Acanthamoeba castellanii. Microbial Pathogenesis, 30, 39–48. [CrossRef] [PubMed] [Google Scholar]
  69. Nguyen TH, Weisenthal RW, Florakis GJ, Reidy JJ, Gaster RN, Tom D. 2010. Penetrating keratoplasty in active Acanthamoeba keratitis. Cornea, 29, 1000–1004. [CrossRef] [PubMed] [Google Scholar]
  70. Niederkorn JY, Alizadeh H, Leher H, McCulley JP. 1999. The pathogenesis of Acanthamoeba keratitis. Microbes and Infection, 1, 437–443. [CrossRef] [Google Scholar]
  71. Page FC, Siemensma FJ. 1991. Nackte Rhizopoda und Heliozoea, in Protozoenfauna, Band 2, Matthes D (Hrsg.). G. Fischer: Stuttgart. [Google Scholar]
  72. Parthasarathy A, Tan DT. 2007. Deep lamellar keratoplasty for Acanthamoeba keratitis. Cornea, 26(8), 1021–1023. [CrossRef] [PubMed] [Google Scholar]
  73. Pellegrin JL, Ortega-Barria E, Barza M, Baum J, Pereira ME. 1991. Neuraminidase activity in Acanthamoeba species trophozoites and cysts. Investigative Ophthalmology and Visual Science, 32, 3061–3066. [Google Scholar]
  74. Pellegrin JL, Ortega-Barria E, Prioli RP, Meijia JS, Pereira ME. 1992. The neuraminidases of Trypanosoma cruzi and Acanthamoeba castellanii are immunologically related. Tropical Medicine and Parasitology, 43, 33–37. [Google Scholar]
  75. Pérez-Serrano J, Martínez J, Pérez B, Bernadina WE, Rodríguez-Caabeiro F. 2000. In vitro shock response to different stressors in free living and pathogenic Acanthamoeba. International Journal of Parasitology, 30(7), 829–835. [CrossRef] [Google Scholar]
  76. Pettit DA, Williamson J, Cabral GA, Marciano-Cabral F. 1996. In vitro destruction of nerve cell cultures by Acanthamoeba spp.: a transmission and scanning electron microscopy study. Journal of Parasitology, 82, 769–777. [CrossRef] [Google Scholar]
  77. Podlipaeva IuI, Shmakov LA, Gilichinskiĭ DA, Gudkov AV. 2006. Heat shock protein of HSP70 family revealed in some contemporary freshwater Amoebae and in Acanthamoeba sp. from cysts isolated from permafrost samples. Tsitologiia, 48(8), 691–694. [PubMed] [Google Scholar]
  78. Polat ZA, Obwaller A, Vural A, Walochnik J. 2012. Efficacy of miltefosine for topical treatment of Acanthamoeba keratitis in Syrian hamsters. Parasitology Research, 110(2), 515–522. [CrossRef] [PubMed] [Google Scholar]
  79. Polat ZA, Walochnik J, Obwaller A, Vural A, Dursun A, Arici MK. 2014. Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis. Clinical and Experimental Ophthalmology, 42(2), 151–158. [CrossRef] [Google Scholar]
  80. Pussard M, Pons R. 1977. Morphologie de la paroi kystique et taxonomie du genre Acanthamoeba (Protozoa, Amoebida). Protistologica, 8, 557–598. [Google Scholar]
  81. Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ. 2006. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. Journal of Clinical Microbiology, 44(10), 3589–3595. [CrossRef] [PubMed] [Google Scholar]
  82. Ren M, Gao L, Wu X. 2010. TLR4: the receptor bridging Acanthamoeba challenge and intracellular inflammatory responses in human corneal cell lines. Immunology and Cell Biology, 88, 529–536. [CrossRef] [PubMed] [Google Scholar]
  83. Ren MY, Wu XY. 2011. Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba keratitis. Parasite Immunology, 33, 25–33. [CrossRef] [PubMed] [Google Scholar]
  84. Rivière D, Szczebara FM, Berjeaud JM, Frère J, Héchard Y. 2006. Development of a real-time PCR assay for quantification of Acanthamoeba trophozoites and cysts. Journal of Microbiological Methods, 64(1), 78–83. [CrossRef] [PubMed] [Google Scholar]
  85. Robaei D, Carnt N, Minassian DC, Dart JK. 2014. The impact of topical corticosteroid use before diagnosis on the outcome of Acanthamoeba keratitis. Ophthalmology, 121(7), 1383–1388. [CrossRef] [PubMed] [Google Scholar]
  86. Roberts CW, Henriquez FL. 2010. Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections. Experimental Parasitology, 126, 91–96. [CrossRef] [PubMed] [Google Scholar]
  87. Rocha-Azevedo BD, Jamerson M, Cabral GA, Silva-Filho FC, Marciano-Cabral F. 2009. Acanthamoeba interaction with extracellular matrix glycoproteins: biological and biochemical characterization and role in cytotoxicity and invasiveness. Journal of Eukaryotic Microbiology, 56, 270–278. [CrossRef] [Google Scholar]
  88. Rondinone CM. 2006. Therapeutic potential of RNAi in metabolic diseases. Biotechniques, 40, 31–36. [CrossRef] [Google Scholar]
  89. Saheb E, Trzyna W, Bush J. 2013. An Acanthamoeba castellanii metacaspase associates with the contractile vacuole and functions in osmoregulation. Experimental Parasitology, 133, 314–326. [CrossRef] [PubMed] [Google Scholar]
  90. Schroeder JM, Booton GC, Hay J, Niszl IA, Seal DV, Markus MB, Fuerst PA, Byers TJ. 2001. Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of Acanthamoeba from humans with keratitis and from sewage sludge. Journal of Clinical Microbiology, 39, 1903–1911. [CrossRef] [PubMed] [Google Scholar]
  91. Schuster FL. 2002. Cultivation of pathogenic and opportunistic free-living amebas. Clinical Microbiology Reviews, 15(3), 342–354. [CrossRef] [PubMed] [Google Scholar]
  92. Schuster FL, Levandowsky M. 1996. Chemosensory responses of Acanthamoeba castellanii: visual analysis of random movement and responses to chemical signals. Journal of Eukaryotic Microbiology, 43, 150–158. [CrossRef] [Google Scholar]
  93. Siddiqui R, Iqbal J, Maugueret MJ, Khan NA. 2012. The role of Src kinase in the biology and pathogenesis of Acanthamoeba castellanii. Parasites and Vectors, 5, 112. [CrossRef] [Google Scholar]
  94. Sissons J, Alsam S, Jayasekera S, Khan NA. 2004. Ecto-ATPases of clinical and non-clinical isolates of Acanthamoeba. Microbial Pathogenesis, 37, 231–239. [CrossRef] [PubMed] [Google Scholar]
  95. Sissons J, Alsam S, Jayasekera S, Kim KS, Stins M, Khan NA. 2004. Acanthamoeba induces cell-cycle arrest in the host cells. Journal of Medical Microbiology, 53, 711–717. [CrossRef] [PubMed] [Google Scholar]
  96. Sissons J, Kim KS, Stins M, Jayasekera S, Alsam S, Khan NA. 2005. Acanthamoeba castellanii induces host cell death via a phosphatidylinositol 3-kinase-dependent mechanism. Infection and. Immunity, 73, 2704–2708. [CrossRef] [PubMed] [Google Scholar]
  97. Stothard DR, Schroeder-Diedrich JM, Awwad MH, Gast RJ, Ledee DR, Rodriguez-Zaragoza S, Dean CL, Fuerst PA, Byers TJ. 1998. The evolutionary history of the genus Acanthamoeba and the identification of eight new 18S rDNA gene sequence types. Journal of Eukaryotic Microbiology, 45, 45–54. [CrossRef] [Google Scholar]
  98. Sun X, Zhang Y, Li R, Wang Z, Luo S, Gao M, Deng S, Chen W, Jin X. 2006. Acanthamoeba keratitis: clinical characteristics and management. Ophthalmology, 113, 412–416. [CrossRef] [PubMed] [Google Scholar]
  99. Szentmáry N, Goebels S, Matoula P, Schirra F, Seitz B. 2012. Die Akanthamöbenkeratitis – ein seltenes und oft spät diagnostiziziertes Chamäleon. Klinische Monatsblätter für Augenheilkunde, 229(5), 521–528. [CrossRef] [Google Scholar]
  100. Taylor WM, Pidherney MS, Alizadeh H, Niederkorn JY. 1995. In vitro characterization of Acanthamoeba castellanii cytopathic effect. Journal of Parasitology, 81, 603–609. [CrossRef] [Google Scholar]
  101. Thomas PA, Kuriakose T. 1990. Rapid detection of Acanthamoeba cysts in corneal scrapings by lactophenol cotton blue staining. Archives of Ophthalmology, 108(2), 168. [CrossRef] [PubMed] [Google Scholar]
  102. Tripathi T, Abdi M, Alizadeh H. 2013. Role of phospholipase A2 (PLA2) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis. Experimental Eye Research, 113, 182–191. [CrossRef] [PubMed] [Google Scholar]
  103. Trzyna WC, Legras XD, Cordingley JS. 2008. A type-1 metacaspase from Acanthamoeba castellanii. Microbiology Research, 163, 414–423. [CrossRef] [Google Scholar]
  104. Tu EY, Joslin CE, Sugar J, Shoff ME, Booton GC. 2008. Prognostic factors affecting visual outcome in Acanthamoeba keratitis. Ophthalmology, 115, 1998–2003. [CrossRef] [PubMed] [Google Scholar]
  105. Tu EY, Joslin CE, Nijm LM, Feder RS, Jain S, Shoff ME. 2009. Polymicrobial keratitis: Acanthamoeba and infectious crystalline keratopathy. American Journal of Ophthalmology, 148, 13–19. [CrossRef] [PubMed] [Google Scholar]
  106. Turner NA, Russell AD, Furr JR, Lloyd D. 2004. Resistance, biguanide sorption and biguanide-induced pentose leakage during encystment of Acanthamoeba castellanii. Journal of Applied Microbiology, 96(6), 1287–1295. [CrossRef] [PubMed] [Google Scholar]
  107. Turner NA, Russell AD, Furr JR, Lloyd D. 2000. Emergence of resistance to biocides during differentiation of Acanthamoeba castellanii. Journal of Antimicrobials and Chemotherapy, 46(1), 27–34. [CrossRef] [Google Scholar]
  108. Ueki N, Eguchi H, Oogi Y, Shiota H, Yamane S, Umazume H, Mizui K. 2009. Three cases of Acanthamoeba keratitis diagnosed and treated in the early stage. Journal of Medical Investigation, 56(3–4), 166–169. [CrossRef] [Google Scholar]
  109. Van Klink F, Alizadeh H, Stewart GL, Pidherney MS, Silvany RE, He Y, McCulley JP, Niederkorn JY. 1992. Characterization and pathogenic potential of a soil isolate and an ocular isolate of Acanthamoeba castellanii in relation to Acanthamoeba keratitis. Current Eye Research, 11, 1207–2012. [CrossRef] [PubMed] [Google Scholar]
  110. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M. 2014. In vivo confocal microscopy of the ocular surface: from bench to bedside. Current Eye Research, 39(3), 213–231. [CrossRef] [PubMed] [Google Scholar]
  111. Visvesvara GS, Moura H, Schuster FL. 2007. Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea. FEMS Immunology and Medical Microbiology, 50(1), 1–26. [Google Scholar]
  112. Visvesvara GS. 2010. Amebic meningoencephalitides and keratitis: challenges in diagnosis and treatment. Current Opinion in Infectious Diseases, 23(6), 590–594. [CrossRef] [PubMed] [Google Scholar]
  113. Walochnik J, Michel R, Aspöck H. 2004. A molecular biological approach to the phylogenetic position of the genus Hyperamoeba. Journal of Eukaryotic Microbiology, 51(4), 433–440. [CrossRef] [Google Scholar]
  114. Walochnik J, Obwaller A, Aspöck H. 2000. Correlations between morphological, molecular biological, and physiological characteristics in clinical and nonclinical isolates of Acanthamoeba spp. Applied and Environmental Microbiology, 66(10), 4408–4413. [CrossRef] [PubMed] [Google Scholar]
  115. Walochnik J, Obwaller A, Haller-Schober EM, Aspöck H. 2001. Anti-Acanthamoeba IgG, IgM, and IgA immunoreactivities in correlation to strain pathogenicity. Parasitology Research, 87(8), 651–656. [CrossRef] [PubMed] [Google Scholar]
  116. Walochnik J, Scheikl U, Haller-Schober EM. 2014. Twenty years of Acanthamoeba diagnostics in Austria. Journal of Eukaryotic Microbiology, 2014 July 22. doi: 10.1111/jeu.12149. [Epub ahead of print]. [Google Scholar]
  117. Wynter-Allison Z, Lorenzo Morales J, Calder D, Radlein K, Ortega-Rivas A, Lindo JF. 2005. Acanthamoeba infection as a cause of severe keratitis in a soft contact lens wearer in Jamaica. American Journal of Tropical Medicine and Hygiene, 73(1), 92–94. [Google Scholar]
  118. Zegans ME, Becker HI, Budzik J, O’Toole G. 2002. The role of bacterial biofilms in ocular infections. DNA and Cell Biology, 21, 415–420. [CrossRef] [PubMed] [Google Scholar]

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