Preventive efficacy of a topical combination of fipronil – (S)-methoprene – eprinomectin – praziquantel against ear mite (Otodectes cynotis) infestation of cats through a natural infestation model

Open Access

Table 1.

Design of the study.

Study day or range	Event
Day −7 to Day 0	Randomly allocate the 12 naive cats to group 1 or 2 Put each group into a specific large room
Day −1	Control the infested status of 6 ear mite-infested “donor cats”
Day 0	Treat group 2 cats
Days 7, 14, 21	Clinical examination of the cats to be sure of their healthy status and that they do not need treatment.
Day 28	All cats Clinical scoring^* Complete ear flush for all cats followed by ear mite counts

Clinical scoring system.

Ear pruritus: 0 = absent; 1 = present and very low; 2 = mild; 3 = pronounced. Cerumen: 0 = absent; 1 = present but clear and with a low volume; 2 = moderate volume and brown color; 3 = abundant dark cerumen.

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