Phenotypic characterization of Leishmania spp. causing cutaneous leishmaniasis in the lower Amazon region, western Pará state, Brazil, reveals a putative hybrid parasite, Leishmania (Viannia) guyanensis × Leishmania (Viannia) shawi shawi

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Table 3.

McAb reaction profiles and serodemes, enzymatic profiles and zymodemes of 43 strains of Leishmania spp. isolated from human cases of cutaneous leishmaniasis from the lower Amazon mesoregion, western Pará state, Brazil.

Leishmania spp. WHO code	McAb reaction-profile	Serodeme	Species^a	Enzymatic profile^b	Zymodeme	Locality^c
MHOM/BR/2001/M19678	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/2001/M19698	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/2001/M19669	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/2001/M19665	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	5
MHOM/BR/2001/M19667	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/2001/M19673	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/1996/M15991	B2, B5, B12, B18, L1, N2	I	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/1996/M15986	B2, B12, B18, L1, N2	II	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/1996/M15923	B5, B12, B18, L1, N2	III	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/1996/M15866	B5, B12, B18, L1, N2	III	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/1996/M15990	B5, B12, B18, L1, N2	III	L. (V.) braziliensis	3; 3; 2; 5; 4; 4	IEC-Z1	1
MHOM/BR/2001/M19869	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	8
MHOM/BR/1997/M16174	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	8
MHOM/BR/1990/M13245	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	8
MHOM/BR/1990/M13102	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	13
MHOM/BR/2001/M19663	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	1
MHOM/BR/2001/M19671^*	B2, B12V, B19, L1 – II	–	L. (V.)s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/2001/M19693^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/2001/M19694^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/1996/M15982^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/1996/M15989	B2, B12V, B19, L1 – II	–	L. (V.) guyanensis	2; 2; 3; 6; 2; 2	IEC-Z2	1
MHOM/BR/1996/M15985^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/1990/M13070^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/1996/M15981^*	B2, B12V, B19, L1 – II	–	L. (V.) s. santarensis	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/1996/M15996	M2, W1, WA2V, L1 – III	–	L. (L.) amazonensis	1; 6; 6; 1; 1; 5	IEC-Z3	2
MHOM/BR/1996/M15807	M2, W1, WA2V, L1 – III	–	L. (L.) amazonensis	1; 6; 6; 1; 1; 5	IEC-Z3	4
MHOM/BR/2001/M19664	B2, B12, L1 – IV	–	L. (V.) s. shawi	5; 1; 4; 7; 3; 2	IEC-Z5	3
MHOM/BR/1996/M15992	B2, B12, L1 – IV	–	L. (V.) s. shawi	5; 1; 4; 7; 3; 2	IEC-Z5	1
MHOM/BR/2001/M19670	B2, B12, L1 – IV	–	L. (V.) s. shawi	5; 1; 4; 7; 3; 2	IEC-Z5	5
MHOM/BR/1990/M19703	B2, B12, L1 – IV	–	L. (V.) s. shawi	5; 1; 4; 7; 3; 2	IEC-Z5	5
MHOM/BR/2001/M19675	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19690	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19692	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19696	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19701	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19702	L1 – V	–	L. (V.) lainsoni	6; 5; 1; 2; 2; 1	IEC-Z4	1
MHOM/BR/2001/M19672	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 4; 6;	IEC-Z9	1
			L. (V.) s. shawi/var2	5; 2
MHOM/BR/2001/M19676	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 4; 6;	IEC-Z9	1
			L. (V.) s. shawi/var2	5; 2
MHOM/BR/2001/M19697	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 4; 6;	IEC-Z9	1
			L. (V.) s. shawi/var2	5; 2
MHOM/BR/1996/M15983	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 4; 6;	IEC-Z9	1
			L. (V.) s. shawi/var2	5; 2
MHOM/BR/1996/M15984	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 3; 6;	IEC-Z8	1
			L. (V.) s. shawi/var1	5; 2
MHOM/BR/1996/M15987	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 3; 6;	IEC-Z8	1
			L. (V.) s. shawi/var1	5; 2
MHOM/BR/1996/M15988	B2, B12V, L1 – VI	–	L. (V.) guyanensis/	2,3,5; 2; 3; 6;	IEC-Z8	1
			L. (V.) s. shawi/var1	5; 2

Definitive nomination of Leishmania spp.

Order of enzymes used for characterization of enzymatic profiles: 6PGDH, G6PD, PGM, MPI, ASAT, ALAT.

Santarém⁽¹⁾, Monte Alegre⁽²⁾, Alenquer⁽³⁾, Prainha⁽⁴⁾, Belterra⁽⁵⁾, Curuá⁽⁶⁾, Placas⁽⁷⁾, Óbidos⁽⁸⁾, Faro⁽⁹⁾, Juruti⁽¹⁰⁾, Terra Santa⁽¹¹⁾, Oriximiná⁽¹²⁾, Almeirim⁽¹³⁾ and Porto de Moz⁽¹⁴⁾.

Strains of L. (V.) s. santarensis that cross-reacted to McAb B19 epitope and were later identified by their isoenzyme electrophoretic profile.

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