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Table 1.

Polymorphisms in the therapeutic targets DHPS and DHFR and the three ABC proteins, TgABC.B1, TgABC.B2, and TgABC.C1, for three sensitive and naturally resistant strains representative of the three major genotypes (I, II, and III) in T. gondii. Only the polymorphisms leading to amino acid changes are represented.

Genotype Sulfadiazine susceptibility TgABC.B1 TgABC.B2 TgABC.C1 dhps dhfr
RH I Sensitive * (20)
T9A, K1285Q
EU213065.1
* (22)
S2N, S267N,
G368D, I509T,
L729M, M848L, L883I
EF418617.1
* (19)
K7E, D491E, T665S
G672E, H954P, G968A
E1125A, S1718R
V1722A, P1785S
FJ201251.1
*(2)
E474K, R560K
A597E
*(1)
PRU II Sensitive 0 0 0 0 0
EU213066.1 EF418618.1 FJ201252.1 GQ415579.1 GQ397454.1
NED III Sensitive * (13) 0 0 0 0
T9A, K1285Q
EU213067.1
EF418619.1 FJ201253.1 GQ415579.1 GQ397454.1
TgA 103001 I Resistant * (19)
T9A, K1285Q
FJ201255.1
* (23)
S2N, S267N,
G368D, I509T,
G816E, M848L, L883I
FJ201256.1
* (23)
K7E, D491E,
G782A
H954P, G968A
E1125A, G1440A, H1659Q,
S1718R, V1722A, P1785S
FJ201254.1
* (2)
E474K,
R560K, A597E
GQ415574.1
* (1)
GQ415574.1
TgH 32006 II Resistant 0 0 0 A587V 0
FJ201257.1 FJ215662.1 GQ865628.1 GQ865628.1 GQ397458.1
TgH 32045 II Variant Resistant * (1) *(1)
L729M
K642E, H1659Q 0 0
FJ201258.1 GQ865630.1 GQ865629.1 GQ415580.1 GQ397459.1
*

corresponds to silent mutations. GenBank accession numbers are indicated for each case.

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