Open Access
Table 1.
Polymorphisms in the therapeutic targets DHPS and DHFR and the three ABC proteins, TgABC.B1, TgABC.B2, and TgABC.C1, for three sensitive and naturally resistant strains representative of the three major genotypes (I, II, and III) in T. gondii. Only the polymorphisms leading to amino acid changes are represented.
| Genotype | Sulfadiazine susceptibility | TgABC.B1 | TgABC.B2 | TgABC.C1 | dhps | dhfr | |
|---|---|---|---|---|---|---|---|
| RH | I | Sensitive | * (20) T9A, K1285Q EU213065.1 |
* (22) S2N, S267N, G368D, I509T, L729M, M848L, L883I EF418617.1 |
* (19) K7E, D491E, T665S G672E, H954P, G968A E1125A, S1718R V1722A, P1785S FJ201251.1 |
*(2) E474K, R560K A597E |
*(1) |
| PRU | II | Sensitive | 0 | 0 | 0 | 0 | 0 |
| EU213066.1 | EF418618.1 | FJ201252.1 | GQ415579.1 | GQ397454.1 | |||
| NED | III | Sensitive | * (13) | 0 | 0 | 0 | 0 |
| T9A, K1285Q EU213067.1 |
EF418619.1 | FJ201253.1 | GQ415579.1 | GQ397454.1 | |||
| TgA 103001 | I | Resistant | * (19) T9A, K1285Q FJ201255.1 |
* (23) S2N, S267N, G368D, I509T, G816E, M848L, L883I FJ201256.1 |
* (23) K7E, D491E, G782A H954P, G968A E1125A, G1440A, H1659Q, S1718R, V1722A, P1785S FJ201254.1 |
* (2) E474K, R560K, A597E GQ415574.1 |
* (1) GQ415574.1 |
| TgH 32006 | II | Resistant | 0 | 0 | 0 | A587V | 0 |
| FJ201257.1 | FJ215662.1 | GQ865628.1 | GQ865628.1 | GQ397458.1 | |||
| TgH 32045 | II Variant | Resistant | * (1) | *(1) L729M |
K642E, H1659Q | 0 | 0 |
| FJ201258.1 | GQ865630.1 | GQ865629.1 | GQ415580.1 | GQ397459.1 |
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