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Emerging screening platform characterises aminoquinoline structure–activity relationships with phospholipid layers
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Magnetic nanoparticle-catalysed synthesis of quinoline derivatives: A green and sustainable method
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Approved drugs successfully repurposed against Leishmania based on machine learning predictions
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Evaluation of the inhibitory effects of sitamaquine on Babesia infections
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Pathobiology of Parasitic Protozoa: Dynamics and Dimensions
Quinolinyl β-enaminone derivatives exhibit leishmanicidal activity against Leishmania donovani by impairing the mitochondrial electron transport chain complex and inducing ROS-mediated programmed cell death
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The Potential of 2-Substituted Quinolines as Antileishmanial Drug Candidates
Philippe M. Loiseau, Kaluvu Balaraman, Gillian Barratt, Sébastien Pomel, Rémy Durand, Frédéric Frézard and Bruno Figadère Molecules 27(7) 2313 (2022) https://doi.org/10.3390/molecules27072313
Discovery of 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-one derivatives as possible antileishmanial agents
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Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents
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Vitória de Souza Fernandes, Rafael da Rosa, Lara A. Zimmermann, Kamilla R. Rogério, Arthur E. Kümmerle, Lilian S. C. Bernardes and Cedric S. Graebin Archiv der Pharmazie 355(2) (2022) https://doi.org/10.1002/ardp.202100338
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Palladium-mediated synthesis and biological evaluation of C-10b substituted Dihydropyrrolo[1,2-b]isoquinolines as antileishmanial agents
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Overcoming multi‐resistant leishmania treatment by nanoencapsulation of potent antimicrobials
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Biological Evaluation and Mechanistic Studies of Quinolin-(1
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In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana
Review on natural products as an alternative to contemporary anti-leishmanial therapeutics
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Synthesis and leishmanicidal evaluation of sulfanyl‐ and sulfonyl‐tethered functionalized benzoate derivatives featuring a nitroimidazole moiety
Miguel Rodríguez, Joyce Gutiérrez, José Domínguez, Philippe A. Peixoto, Alexis Fernández, Noris Rodríguez, Denis Deffieux, Luis Rojas, Stéphane Quideau, Laurent Pouységu and Jaime Charris Archiv der Pharmazie 353(5) (2020) https://doi.org/10.1002/ardp.202000002
Pre-clinical evidences of the antileishmanial effects of diselenides and selenocyanates
Pablo Garnica, Mikel Etxebeste-Mitxeltorena, Daniel Plano, et al. Bioorganic & Medicinal Chemistry Letters 30(17) 127371 (2020) https://doi.org/10.1016/j.bmcl.2020.127371
Nanotechnology in Skin, Soft Tissue, and Bone Infections
Marco Vinicius Chaud, Venâncio Alves Amaral, Fernando Batain, et al. Nanotechnology in Skin, Soft Tissue, and Bone Infections 183 (2020) https://doi.org/10.1007/978-3-030-35147-2_11
Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
Soraya Silva Santos, Renan Vinicius de Araújo, Jeanine Giarolla, Omar El Seoud and Elizabeth Igne Ferreira International Journal of Antimicrobial Agents 55(4) 105906 (2020) https://doi.org/10.1016/j.ijantimicag.2020.105906
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Vladimir V. Kouznetsov, Carlos M. Meléndez Gómez, José Luis Valencia Peña and Leonor Y. Vargas-Méndez Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases 87 (2019) https://doi.org/10.1016/B978-0-12-815723-7.00004-3
Targeting Pteridine Reductase 1 and Dihydrofolate Reductase: The Old is a New Trend for Leishmaniasis Drug Discovery
Gustavo Machado das Neves, Luciano P Kagami, Itamar L Gonçalves and Vera L Eifler-Lima Future Medicinal Chemistry 11(16) 2107 (2019) https://doi.org/10.4155/fmc-2018-0512
Structure-activity relationships and mechanistic studies of novel mitochondria-targeted, leishmanicidal derivatives of the 4-aminostyrylquinoline scaffold
Enhancing the copy number of Ldrab6 gene in Leishmania donovani parasites mediates drug resistance through drug‐thiol conjugate dependent multidrug resistance protein A (MRPA)
Cinnamic Acid Conjugates in the Rescuing and Repurposing of Classical Antimalarial Drugs
Ana Teresa Silva, Clara M. Bento, Ana C. Pena, Luísa M. Figueiredo, Cristina Prudêncio, Luísa Aguiar, Tânia Silva, Ricardo Ferraz, Maria Salomé Gomes, Cátia Teixeira and Paula Gomes Molecules 25(1) 66 (2019) https://doi.org/10.3390/molecules25010066
Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasis
The alkylaminoalkanethiosulfuric acids exhibit in-vitro antileishmanial activity against Leishmania (Viannia) braziliensis: a new perspective for use of these schistosomicidal agents
Gabriane Nascimento Porcino, Luciana Maria Ribeiro Antinarelli, Ana Carolina Ribeiro Gomes Maia, Priscila Faria-Pinto, Alessandro Taunay-Rodrigues, Paulo Marcos Zech Coelho, David Lee Nelson, Marcus Luiz Oliveira Penido, Elaine Soares Coimbra and Eveline Gomes Vasconcelos Journal of Pharmacy and Pharmacology 71(12) 1784 (2019) https://doi.org/10.1111/jphp.13163
Synthesis and biological evaluation of new quinoline derivatives as antileishmanial and antitrypanosomal agents
Therapeutic Interventions for Countering Leishmaniasis and Chagas’s Disease: From Traditional Sources to Nanotechnological Systems
Eliana B. Souto, João Dias-Ferreira, Sara A. Craveiro, Patrícia Severino, Elena Sanchez-Lopez, Maria L. Garcia, Amélia M. Silva, Selma B. Souto and Sheefali Mahant Pathogens 8(3) 119 (2019) https://doi.org/10.3390/pathogens8030119
Antileishmanial activity of a 4-hydrazinoquinoline derivative: Induction of autophagy and apoptosis-related processes and effectiveness in experimental cutaneous leishmaniasis
Luciana Maria Ribeiro Antinarelli, Isabela de Oliveira Souza, Priscila Vanessa Zabala Capriles, et al. Experimental Parasitology 195 78 (2018) https://doi.org/10.1016/j.exppara.2018.10.007
Neglected Diseases: Extensive Space for Modern Drug Discovery
Chiara Borsari, Antonio Quotadamo, Stefania Ferrari, et al. Annual Reports in Medicinal Chemistry, Neglected Diseases: Extensive Space for Modern Drug Discovery 51 39 (2018) https://doi.org/10.1016/bs.armc.2018.08.002
Polyamine-based analogs and conjugates as antikinetoplastid agents
Elodie Jagu, Sébastien Pomel, Stéphanie Pethe, Philippe M. Loiseau and Raphaël Labruère European Journal of Medicinal Chemistry 139 982 (2017) https://doi.org/10.1016/j.ejmech.2017.08.014
An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Mark C. Field, David Horn, Alan H. Fairlamb, Michael A. J. Ferguson, David W. Gray, Kevin D. Read, Manu De Rycker, Leah S. Torrie, Paul G. Wyatt, Susan Wyllie and Ian H. Gilbert Nature Reviews Microbiology 15(4) 217 (2017) https://doi.org/10.1038/nrmicro.2016.193
Library of Seleno-Compounds as Novel Agents against Leishmania Species
Álvaro Martín-Montes, Daniel Plano, Rubén Martín-Escolano, et al. Antimicrobial Agents and Chemotherapy 61(6) (2017) https://doi.org/10.1128/AAC.02546-16
Antimicrobial Drug Resistance
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Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents
Ylenia Baquedano, Verónica Alcolea, Miguel Ángel Toro, et al. Antimicrobial Agents and Chemotherapy 60(6) 3802 (2016) https://doi.org/10.1128/AAC.02529-15
Zinc(II)-Dipicolylamine Coordination Complexes as Targeting and Chemotherapeutic Agents for Leishmania major
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In vitro antileishmanial activity of aza-scorpiand macrocycles. Inhibition of the antioxidant enzyme iron superoxide dismutase
Imidazole-containing phthalazine derivatives inhibit Fe-SOD performance in Leishmania species and are active in vitro against visceral and mucosal leishmaniasis
The Dialogue of the Host-Parasite Relationship:Leishmaniaspp. andTrypanosoma cruziInfection
Carlos Gustavo Vieira de Morais, Ana Karina Castro Lima, Rodrigo Terra, et al. BioMed Research International 2015 1 (2015) https://doi.org/10.1155/2015/324915
4‐Aminoquinoline Derivatives as Potential Antileishmanial Agents
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Finding of leishmanicidal activity of 14-hydroxylunularin in mice experimentally infected with Leishmania infantum
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity
Rosemary Rochford, Colin Ohrt, Paul C. Baresel, et al. Proceedings of the National Academy of Sciences 110(43) 17486 (2013) https://doi.org/10.1073/pnas.1310402110
Developments in diagnosis and treatment of visceral leishmaniasis during the last decade and future prospects
Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix
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