Open Access
Research Article
Volume 24, 2017
Article Number 41
Number of page(s) 9
Published online 09 November 2017
  1. Ahmadpour E, Sarvi S, Hashemi Soteh MB, Sharif M, Rahimi MT, Valadan R, Tehrani M, Khalilian A, Montazeri M, Daryani A. 2017. Evaluation of the immune response in BALB/c mice induced by a novel DNA vaccine expressing GRA14 against Toxoplasma gondii. Parasite Immunology, 39(4). doi: 10.1111/pim.12419 [CrossRef]
  2. Brown CR, McLeod R. 1990. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. Journal of Immunology, 145(10), 3438-3441.
  3. Cao A, Liu Y, Wang J, Li X, Wang S, Zhao Q, Cong H, He S, Zhou H. 2015. Toxoplasma gondii: Vaccination with a DNA vaccine encoding T- and B-cell epitopes of SAG1, GRA2, GRA7 and ROP16 elicits protection against acute toxoplasmosis in mice. Vaccine, 33(48), 6757-6762. [CrossRef]
  4. Cenci-Goga BT, Rossitto PV, Sechi P, McCrindle CM, Cullor JS. 2011. Toxoplasma in animals, food, and humans: an old parasite of new concern. Foodborne Pathogens and Disease, 8(7), 751-762. [CrossRef] [PubMed]
  5. Chellan P, Sadler PJ, Land KM. 2017. Recent developments in drug discovery against the protozoal parasites Cryptosporidium and Toxoplasma. Bioorganic & Medicinal Chemistry Letters, 27(7), 1491-1501. [CrossRef] [PubMed]
  6. Chen J, Li ZY, Huang SY, Petersen E, Song HQ, Zhou DH, Zhu XQ. 2014. Protective efficacy of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice. BMC Infectious Diseases, 14, 487. [CrossRef] [PubMed]
  7. Chen R, Lu SH, Tong QB, Lou D, Shi DY, Jia BB, Huang GP, Wang JF. 2009. Protective effect of DNA-mediated immunization with liposome-encapsulated GRA4 against infection of Toxoplasma gondii. Journal of Zhejiang University Science B, 10(7), 512-521. [CrossRef] [PubMed]
  8. Cong W, Liu GH, Meng QF, Dong W, Qin SY, Zhang FK, Zhang XY, Wang XY, Qian AD, Zhu XQ. 2015. Toxoplasma gondii infection in cancer patients: prevalence, risk factors, genotypes and association with clinical diagnosis. Cancer Letters, 359(2), 307-313.
  9. Correa D, Canedo-Solares I, Ortiz-Alegria LB, Caballero-Ortega H, Rico-Torres CP. 2007. Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host. Parasite Immunology, 29(12), 651-660. [CrossRef] [PubMed]
  10. Donnelly JJ, Wahren B, Liu MA. 2005. DNA vaccines: progress and challenges. Journal of Immunology, 175(2), 633-639. [CrossRef]
  11. Gavrilescu LC, Butcher BA, Del Rio L, Taylor GA, Denkers EY. 2004. STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infection and Immunity, 72(3), 1257-1264. [CrossRef] [PubMed]
  12. Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kuhn R, Muller W, Trinchieri G, Sher A. 1996. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. Journal of Immunology, 157(2), 798-805.
  13. Harper JF, Harmon A. 2005. Plants, symbiosis and parasites: a calcium signalling connection. Nature Reviews Molecular Cell Biology, 6(7), 555-566. [CrossRef] [PubMed]
  14. Hiszczynska-Sawicka E, Holec-Gasior L, Kur J. 2009. DNA vaccines and recombinant antigens in prevention of Toxoplasma gondii infections–current status of the studies. Wiadomosci Parazytologiczne, 55(2), 125-139. [in Polish]
  15. Hunter CA, Sibley LD. 2012. Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nature Reviews Microbiology, 10(11), 766-778. [CrossRef] [PubMed]
  16. Hunter CA, Subauste CS, Van Cleave VH, Remington JS. 1994. Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha. Infection and Immunity, 62(7), 2818-2824. [PubMed]
  17. Jongert E, Roberts CW, Gargano N, Forster-Waldl E, Petersen E. 2009. Vaccines against Toxoplasma gondii: challenges and opportunities. Memórias do Instituto Oswaldo Cruz, 104 (2), 252-266. [CrossRef]
  18. Jordan KA, Hunter CA. 2010. Regulation of CD8+ T cell responses to infection with parasitic protozoa. Experimental Parasitology, 126(3), 318-325. [CrossRef] [PubMed]
  19. Khan IA, Matsuura T, Kasper LH. 1994. Interleukin-12 enhances murine survival against acute toxoplasmosis. Infection and Immunity, 62(5), 1639-1642. [PubMed]
  20. Kijlstra A, Jongert E. 2008. Control of the risk of human toxoplasmosis transmitted by meat. International Journal for Parasitology, 38(12), 1359-1370. [CrossRef] [PubMed]
  21. Li WS, Chen QX, Ye JX, Xie ZX, Chen J, Zhang LF. 2011. Comparative evaluation of immunization with recombinant protein and plasmid DNA vaccines of fusion antigen ROP2 and SAG1 from Toxoplasma gondii in mice: cellular and humoral immune responses. Parasitology Research, 109(3), 637-644. [CrossRef] [PubMed]
  22. Li ZY, Chen J, Petersen E, Zhou DH, Huang SY, Song HQ, Zhu XQ. 2014. Synergy of mIL-21 and mIL-15 in enhancing DNA vaccine efficacy against acute and chronic Toxoplasma gondii infection in mice. Vaccine, 32(25), 3058-3065. [CrossRef] [PubMed]
  23. Lieberman LA, Banica M, Reiner SL, Hunter CA. 2004. STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis. Journal of Immunology, 172(1), 457-463. [CrossRef]
  24. Liu S, Shi L, Cheng YB, Fan GX, Ren HX, Yuan YK. 2009. Evaluation of protective effect of multi-epitope DNA vaccine encoding six antigen segments of Toxoplasma gondii in mice. Parasitology Research, 105(1), 267-274. [CrossRef] [PubMed]
  25. Lourido S, Shuman J, Zhang C, Shokat KM, Hui R, Sibley LD. 2010. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature, 465(7296: 359-362. [CrossRef] [PubMed]
  26. Lourido S, Tang KL, Sibley LD. 2012. Distinct signalling pathways control Toxoplasma egress and host-cell invasion. EMBO Journal, 31(24), 4524-4534. [CrossRef]
  27. Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM. 2011. CD8 alpha(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity, 35(2), 249-259. [CrossRef] [PubMed]
  28. Montoya JG, Liesenfeld O. 2004. Toxoplasmosis. Lancet, 363(9425), 1965-1976. [CrossRef] [PubMed]
  29. Mordue DG, Monroy F, La Regina M, Dinarello CA, Sibley LD. 2001. Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. Journal of Immunology, 167(8), 4574-4584. [CrossRef]
  30. Morlon-Guyot J, Berry L, Chen CT, Gubbels MJ, Lebrun M, Daher W. 2014. The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival. Cellular Microbiology, 16(1), 95-114. [CrossRef] [PubMed]
  31. Nielsen HV, Lauemoller SL, Christiansen L, Buus S, Fomsgaard A, Petersen E. 1999. Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. Infection and Immunity, 67(12), 6358-6363. [PubMed]
  32. Quan JH, Chu JQ, Ismail HA, Zhou W, Jo EK, Cha GH, Lee YH. 2012. Induction of protective immune responses by a multiantigenic DNA vaccine encoding GRA7 and ROP1 of Toxoplasma gondii. Clinical and Vaccine Immunology, 19(5), 666-674. [CrossRef]
  33. SchartonKersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A. 1996. In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. Journal of Immunology, 157(9), 4045-4054.
  34. Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJP, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL1, Webb AI1, McConville MJ, Tonkin CJ. 2015. Regulation of starch stores by a Ca2+-dependent protein kinase is essential for viable cyst development in Toxoplasma gondii. Cell Host & Microbe, 18(6), 670-681.
  35. van Asseldonk M, van Wagenberg CP, Wisselink HJ. 2017. Break-even analysis of costs for controlling Toxoplasma gondii infections in slaughter pigs via a serological surveillance program in the Netherlands. Preventive Veterinary Medicine, 138, 139-146. [CrossRef] [PubMed]
  36. Wang HL, Wang YJ, Pei YJ, Bai JZ, Yin LT, Guo R, Yin GR. 2016. DNA vaccination with a gene encoding Toxoplasma gondii Rhoptry Protein 17 induces partial protective immunity against lethal challenge in mice. Parasite, 23, 4. [CrossRef] [EDP Sciences] [PubMed]
  37. Wang T, Yin HQ, Li Y, Zhao LZ, Sun XH, Cong H. 2017. Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes. Parasite, 24, 12. [CrossRef] [EDP Sciences] [PubMed]
  38. Yan HK, Yuan ZG, Petersen E, Zhang XX, Zhou DH, Liu Q, He Y, Lin RQ, Xu MJ, Chen XL, Zhong XL, Zhu XQ. 2011. Toxoplasma gondii: protective immunity against experimental toxoplasmosis induced by a DNA vaccine encoding the perforin-like protein 1. Experimental Parasitology, 128(1), 38-43. [CrossRef] [PubMed]
  39. Wang ZD, Liu HH, Ma ZX, Ma HY, Li ZY, Yang ZB, Zhu XQ, Xu B, Wei F, Liu Q. 2017. Toxoplasma gondii infection in immunocompromised patients: a systematic review and meta-analysis. Frontiers in Microbiology, 8, 389. [PubMed]
  40. Zasukhin DN. 1954. Toxoplasmosis in humans and animals. Meditsinskaia Parazitologiia i Parazitarnye Bolezni, 23, 3-6. [in Russian]
  41. Zhang NZ, Huang SY, Xu Y, Chen J, Wang JL, Tian WP, Zhu XQ. 2014. Evaluation of Immune Responses in mice after DNA immunization with putative Toxoplasma gondii calcium-dependent protein kinase 5. Clinical and Vaccine Immunology, 21(7), 924-929. [CrossRef]
  42. Zhang NZ, Huang SY, Zhou DH, Chen J, Xu Y, Tian WP, Lu J, Zhu XQ. 2013. Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3. BMC Infectious Diseases, 13, 512. [CrossRef] [PubMed]
  43. Zhang NZ, Xu Y, Wang M, Chen J, Huang SY, Gao Q, Zhu XQ. 2016. Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly (lactide-co-glycolide) microspheres induces long-term protective immunity in mice. BMC Infectious Diseases, 16, 168. [CrossRef] [PubMed]
  44. Zheng B, Ding J, Chen X, Yu H, Lou D, Tong Q, Kong Q, Lu S. 2017. Immuno-efficacy of a T. gondii secreted protein with an altered thrombospondin repeat (TgSPATR) as a novel DNA vaccine candidate against acute toxoplasmosis in BALB/c mice. Frontiers in Microbiology, 8, 216. [PubMed]
  45. Zheng L, Hu Y, Hua Q, Luo F, Xie G, Li X, Lin J, Wan Y, Ren S, Pan C, Tan F. 2017. Protective immune response in mice induced by a suicidal DNA vaccine encoding NTPase-II gene of Toxoplasma gondii. Acta Tropica, 166, 336-342. [CrossRef] [PubMed]
  46. Zhou J, Wang L, Lu G, Zhou A, Zhu M, Li Q, Wang Z, Arken M, Wang A, He S. 2016. Epitope analysis and protection by a ROP19 DNA vaccine against Toxoplasma gondii. Parasite, 23, 17. [CrossRef] [EDP Sciences] [PubMed]
  47. Zhu WN, Wang JL, Chen K, Yue DM, Zhang XX, Huang SY, Zhu XQ. 2017. Evaluation of protective immunity induced by DNA vaccination with genes encoding Toxoplasma gondii GRA17 and GRA23 against acute toxoplasmosis in mice. Experimental Parasitology, 179, 20-27. [CrossRef] [PubMed]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.