Open Access
Research Article
Volume 21, 2014
Article Number 19
Number of page(s) 7
Published online 24 April 2014
  1. Anonymous. 2013. World Malaria Report 2013. World Health Organization. [Google Scholar]
  2. Barry AE, Trieu A, Fowkes FJ, Pablo J, Kalantari-Dehaghi M, Jasinskas A, Tan X, Kayala MA, Tavul L, Siba PM, Day KP, Baldi P, Felgner PL, Doolan DL. 2011. The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area. Molecular & Cellular Proteomics, 10, M111.008326. [CrossRef] [Google Scholar]
  3. Cham GK, Turner L, Lusingu J, Vestergaard L, Mmbando BP, Kurtis JD, Jensen AT, Salanti A, Lavstsen T, Theander TG. 2009. Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains. Journal of Immunology, 183, 3356–3363. [CrossRef] [Google Scholar]
  4. Chen Q, Fernandez V, Sundström A, Schlichtherle M, Datta S, Hagblom P, Wahlgren M. 1998. Developmental selection of var gene expression in Plasmodium falciparum. Nature, 394, 392–395. [CrossRef] [PubMed] [Google Scholar]
  5. Chen Q. 2007. The naturally acquired immunity in severe malaria and its implication for a PfEMP-1 based vaccine. Microbes and Infection, 9, 777–783. [CrossRef] [Google Scholar]
  6. Dahlbäck M, Lavstsen T, Salanti A, Hviid L, Arnot DE, Theander TG, Nielsen MA. 2007. Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites. Malaria Journal, 6, 78. [CrossRef] [PubMed] [Google Scholar]
  7. Epp C, Li F, Howitt CA, Chookajorn T, Deitsch KW. 2009. Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum. RNA, 15, 116–127. [CrossRef] [PubMed] [Google Scholar]
  8. Flick K, Chen Q. 2004. var genes, PfEMP1 and the human host. Molecular and Biochemical Parasitology, 134, 3–9. [CrossRef] [PubMed] [Google Scholar]
  9. Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE. 1998. Maternal antibodies block malaria. Nature, 395, 851–852. [CrossRef] [PubMed] [Google Scholar]
  10. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B. 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419, 498–511. [CrossRef] [PubMed] [Google Scholar]
  11. Hinterberg K, Scherf A, Gysin J, Toyoshima T, Aikawa M, Mazie JC, da Silva LP, Mattei D. 1994. Plasmodium falciparum: the Pf332 antigen is secreted from the parasite by a brefeldin A-dependent pathway and is translocated to the erythrocyte membrane via the Maurer’s clefts. Experimental Parasitology, 79, 279–291. [CrossRef] [PubMed] [Google Scholar]
  12. Joergensen L, Bengtsson DC, Bengtsson A, Ronander E, Berger SS, Turner L, Dalgaard MB, Cham GK, Victor ME, Lavstsen T, Theander TG, Arnot DE, Jensen AT. 2010. Surface co-expression of two different PfEMP1 antigens on single Plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1. PLoS Pathogens, 6, e1001083. [CrossRef] [PubMed] [Google Scholar]
  13. Juillerat A, Lewit-Bentley A, Guillotte M, Gangnard S, Hessel A, Baron B, Vigan-Womas I, England P, Mercereau-Puijalon O, Bentley GA. 2011. Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition. Proceedings of the National Academy of Sciences of the United States of America, 108, 5243–5248. [CrossRef] [PubMed] [Google Scholar]
  14. Kinyanjui SM, Howard T, Williams TN, Bull PC, Newbold CI, Marsh K. 2004. The use of cryopreserved mature trophozoites in assessing antibody recognition of variant surface antigens of Plasmodium falciparum-infected erythrocytes. Journal of Immunological Methods, 288, 9–18. [CrossRef] [PubMed] [Google Scholar]
  15. Kirchgatter K, Portillo Hdel A. 2002. Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residues. Molecular Medicine, 8, 16–23. [Google Scholar]
  16. Kraemer SM, Smith JD. 2006. A family affair: var genes, PfEMP1 binding, and malaria disease. Current Opinion in Microbiology, 9, 374–380. [CrossRef] [PubMed] [Google Scholar]
  17. Kyes S, Horrocks P, Newbold C. 2001. Antigenic variation at the infected red cell surface in malaria. Annual Review of Microbiology, 55, 673–707. [CrossRef] [PubMed] [Google Scholar]
  18. Kyriacou HM, Stone GN, Challis RJ, Raza A, Lyke KE, Thera MA, Kone AK, Doumbo OK, Plowe CV, Rowe JA. 2006. Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. Molecular and Biochemical Parasitology, 150, 211–218. [CrossRef] [PubMed] [Google Scholar]
  19. Lavstsen T, Salanti A, Jensen AT, Arnot DE, Theander TG. 2003. Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Malaria Journal, 2, 27. [CrossRef] [PubMed] [Google Scholar]
  20. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402–408. [CrossRef] [PubMed] [Google Scholar]
  21. Moll K, Chene A, Ribacke U, Kaneko O, Nilsson S, Winter G, Haeggstrom M, Pan W, Berzins K, Wahlgren M, Chen Q. 2007. A novel DBL-domain of the P. falciparum 332 molecule possibly involved in erythrocyte adhesion. PLoS One, 2, e477. [CrossRef] [PubMed] [Google Scholar]
  22. Rask TS, Hansen DA, Theander TG, Gorm Pedersen A, Lavstsen T. 2010. Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes – divide and conquer. PLoS Computational Biology, 6, e1000933. [CrossRef] [PubMed] [Google Scholar]
  23. Rorick MM, Rask TS, Baskerville EB, Day KP, Pascual M. 2013. Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population. BMC Microbiology, 13, 244. [CrossRef] [PubMed] [Google Scholar]
  24. Scherf A, Hernandez-Rivas R, Buffet P, Bottius E, Benatar C, Pouvelle B, Gysin J, Lanzer M. 1998. Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum. EMBO Journal, 17, 5418–5426. [CrossRef] [Google Scholar]
  25. Scherf A, Pouvelle B, Buffet PA, Gysin J. 2001. Molecular mechanisms of Plasmodium falciparum placental adhesion. Cellular Microbiology, 3, 125–131. [CrossRef] [PubMed] [Google Scholar]
  26. Smith DB, Johnson KS. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene, 67, 31–40. [CrossRef] [PubMed] [Google Scholar]
  27. Su XZ, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA, Wellems TE. 1995. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes. Cell, 82, 89–100. [CrossRef] [PubMed] [Google Scholar]
  28. Trager W, Jensen JB. 2005. Human malaria parasites in continuous culture. Journal of Parasitology, 91, 484–486. [CrossRef] [Google Scholar]
  29. Trimnell AR, Kraemer SM, Mukherjee S, Phippard DJ, Janes JH, Flamoe E, Su XZ, Awadalla P, Smith JD. 2006. Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Molecular and Biochemical Parasitology, 148, 169–180. [CrossRef] [PubMed] [Google Scholar]
  30. Wang CW, Lavstsen T, Bengtsson DC, Magistrado PA, Berger SS, Marquard AM, Alifrangis M, Lusingu JP, Theander TG, Turner L. 2012. Evidence for in vitro and in vivo expression of the conserved var3 (type 3) plasmodium falciparum erythrocyte membrane protein 1. Malaria Journal, 11, 129. [CrossRef] [PubMed] [Google Scholar]
  31. Warimwe GM, Fegan G, Musyoki JN, Newton CR, Opiyo M, Githinji G, Andisi C, Menza F, Kitsao B, Marsh K, Bull PC. 2012. Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profiles. Science Translational Medicine, 4, 129ra45. [CrossRef] [PubMed] [Google Scholar]
  32. Warimwe GM, Recker M, Kiragu EW, Buckee CO, Wambua J, Musyoki JN, Marsh K, Bull PC. 2013. Plasmodium falciparum var gene expression homogeneity as a marker of the host-parasite relationship under different levels of naturally acquired immunity to malaria. PLoS One, 8, e70467. [CrossRef] [PubMed] [Google Scholar]

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.