Influence of neurotoxocarosis on behavior of APP/PS1 mice. (A) Frequency of open arm visits was lower in APP/PS1 compared to WT mice –1 WPI, but notably increased 16 WPI. (B) Total distance walked was altered by neither genotype nor time point. (C) APP/PS1 mice spent more time at the center of the open field compared to WT across all time points; this parameter was notably increased 16 WPI in both groups. (D) Total distance walked in the open field was comparable between WT and APP/PS1, with a dramatic increase 16 WPI seen in both groups. (E) Spontaneous alternation was not affected by genotype but differed across time points. (F) Total arm visits were affected by neither time point nor genotype. Individual data are shown along with the group median. A mixed-effects model was used along with Holm-Šidák’s multiple comparisons test to detect differences at particular time points. Significant differences among WT and APP/PS1 mice are indicated by asterisks (*p ≤ 0.05). If the animal fell from the apparatus (EPM) or was not moving (Y-maze), it was excluded from the data sets, which explains lower n indicated in some cases.