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Schematic life cycle of Trypanosoma brucei. 1: Bloodstream trypanosomes in mammalian host; A: long slender form; B: short stumpy form. 2: Procyclic trypanosomes in tsetse fly midgut. 3: Epimastigote trypanosomes colonize salivary glands. 4: Metacyclic trypanosomes in salivary glands can be transmitted to a mammalian host during the next tsetse fly meal. In red: localization of the parasites in the tsetse fly through the cycle.

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