Table 2
Distribution of MDSCs and lymphocyte subsets in S. japonicum-infected patients and healthy controls.
| All persons, n = 77 | SJ, n = 56 |
Healthy controls, n = 21 | p value◇ | |||
|---|---|---|---|---|---|---|
| CSJ, n = 38 | ASJ, n = 18 | p value▽ | ||||
| Percent of MDSCs among CD45+ PBMCs (Mean ± SD) (%) | 26.71 ± 20.75 | 34.85 ± 18.61 | 5.03 ± 2.07 | <0.001 | ||
| 31.84 ± 17.11 | 41.20 ± 20.51 | 0.079 | ||||
| Percent of G-MDSCs among CD45+ PBMCs (Mean ± SD) (%) | 23.53 ± 21.44 | 32.25 ± 18.76 | 0.30 ± 0.36 | <0.001 | ||
| 29.39 ± 17.92 | 38.27 ± 19.57 | 0.099 | ||||
| Percent of M-MDSCs among CD45+ PBMCs (Mean ± SD) (%) | 3.18 ± 2.37 | 2.60 ± 2.24 | 4.73 ± 2.01 | <0.001 | ||
| 2.44 ± 1.59 | 2.93 ± 3.25 | 0.454 | ||||
| Absolute cell counts of CD3+ cells (Mean ± SD) (109/L) | 1.08 ± 0.44 | 1.07 ± 0.48 | 1.13 ± 0.35 | 0.583 | ||
| 1.12 ± 0.40 | 0.95 ± 0.60 | 0.199 | ||||
| Absolute cell counts of CD3+ CD4+ cells (Mean ± SD) (109/L) | 0.59 ± 0.22 | 0.59 ± 0.23 | 0.59 ± 0.20 | 0.997 | ||
| 0.63 ± 0.21 | 0.50 ± 0.25 | 0.051 | ||||
| Absolute cell counts of CD3+ CD8+ cells (Mean ± SD) (109/L) | 0.43 ± 0.26 | 0.41 ± 0.30 | 0.46 ± 0.15 | 0.496 | ||
| 0.41 ± 0.25 | 0.41 ± 0.38 | 0.963 | ||||
| Absolute cell counts of CD19+ cells (Mean ± SD) (109/L) | 0.19 ± 0.11 | 0.19 ± 0.11 | 0.19 ± 0.12 | 0.734 | ||
| 0.19 ± 0.09 | 0.18 ± 0.13 | 0.776 | ||||
| Absolute cell counts of CD16+ CD56+ cells (Mean ± SD) (109/L) | 0.31 ± 0.22 | 0.35 ± 0.25 | 0.22 ± 0.09 | 0.023 | ||
| 0.37 ± 0.26 | 0.29 ± 0.21 | 0.271 | ||||
▽: Comparison between patients with CSJ and ASJ; ◇: Comparison between healthy controls and S. japonicum-infected patients.
MDSCs, myeloid-derived suppressor cells. S. japonicum, Schistosoma japonicum. SJ, schistosomiasis japonica. CSJ, chronic schistosomiasis japonica. ASJ, advanced schistosomiasis japonica. PBMCs, peripheral blood mononuclear cells. SD, standard deviation. G-MDSCs, granulocytic myeloid-derived suppressor cells. M-MDSCs, monocytic myeloid-derived suppressor cells.
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