Open Access

Table 3

Amino acids at the binding pocket and type of bonds involved. Different polymorphisms of AChE2 result in different amino acid compositions in the binding pocket, which in turn results indifferent types of bonds with diazoxon ligand.

Strain/Isolate Binding pocket Hydrogen bonds Hydrophobic bonds Ionic bonds
Susceptible F107, S108, W114, G150, E154 L161, W229, N359, I360,T363, R366, H476, D478, G477 E154-G150 W114-L-161 E154-Diazoxon
R366-F107 W114-W229
N359-T363 I159-L161
T363-I360 F107-T363
H476-N359 W114-Diazoxon
G150-E154 I360-Diazoxon
N-Diazoxon W229-Diazoxon
C1 V106, F107, S108, P109, R110, G149, G150, E154, G155, I159, L161, W229, N359, I360, T363 H476, L480 H476-E356 W229-Diazoxon G154-Diazoxon
H476-N359 I360-Diazoxon R110-Diazoxon
T363-I360 T363-Diazoxon
N359-T363 P109-Diazoxon
T364-I360 L161-Diazoxon
Y362-S358 I159-Diazoxon
C2 V106, F107, S108, P109, R110, Y117, G149, G150, E154, G155, I159, L161, W229, N359, I360, T363, H476, G477, L480 H476-N359 F107-T363 H476-Diazoxon
N359-T363 I159-L161 N359-Diazoxon
I360-T363 F107-Diazoxon R110-Diazoxon
Y362-S358 W229-Diazoxon
G357-L361 V106-Diazoxon
H476-E356 L161-Diazoxon
F472-S368 I159-Diazoxon
N355-S358 R110-Diazoxon
D359-Diazoxon T363-Diazoxon

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.