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Figure 4


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RNA expression of investigated target genes in strain Neff after treatment with auranofin for 48 h. High-molecular weight thioredoxin reductase (TrxR-L), low-molecular weight thioredoxin reductase (TrxR-S), thioredoxin 1 (Trx-1), peroxiredoxin 2 (Prx-2), glutaredoxin 1 (Grx-1), glutathione reductase (GR), glutathione peroxidase (Gpx), untreated control (C). Grey bars: 10 μM auranofin; black bars: 20 μM auranofin. The y-axis indicates – fold increase of mRNA levels as compared to untreated controls. Error bars show the standard deviation of the mean (SEM). Values were obtained from at least three biological replicates in triplicate. *p < 0.05, **p < 0.01, and ***p < 0.0001 according to statistical analysis (nonparametric Mann–Whitney U test).

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