Efficacy of two endectoparasiticide products combining fipronil and (S)-methoprene or esafoxolaner with eprinomectin and praziquantel against fleas and intestinal helminths in cats naturally infested in Brazil

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 2

Gastro-intestinal helminths efficacy results.

		Ancylostoma			Toxocara			Dipylidium caninum
		Day 0	Day 9	Day 39	Day 0	Day 9	Day 39	Day 0	Day 9	Day 39
Broadline^®	n cats	143	143	143	42	42	42	46	46	46
	Geo Mean	459.2	0.9	0.3	190.9	0.2	0.1	1.6	0.0	0.0
	% efficacy		99.8	99.9		99.9	99.9		98.0	97.0
	p-value		<0.0001	<0.0001		<0.0001	<0.0001		<0.0007	<0.0012
NexGard^® Combo	n cats	137	137	137	44	44	44	47	47	47
	Geo Mean	426.2	0.6	0.3	202.8	0.4	0.2	1.65	0.06	0.03
	% efficacy		99.9	99.9		99.8	99.9		96.3	98.2
	p-value		<0.0001	<0.0001		<0.0001	<0.0001		<0.0009	<0.0006

Geo Mean = geometric mean of eggs per gram (EPG) for Ancylostoma and Toxocara, and proglottids for Dipylidium.

Percent efficacy = 100[(C − T)/C], where C is the geometric (Geo) mean at baseline (Day 0) and T is the geometric mean at evaluation timepoints.

Two-sided probability value from analysis of variance on log-counts of the mean at baseline and evaluation timepoints.

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