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miR-155 deficiency exacerbated CD8+ T cell exhaustion by targeting to SHIP-1 and SOCS1. Spleens were collected from each mouse in the WT and miR-155−/− groups. The percentages of Tregs, IFN-γ CD8+ T, TNF-α CD8+ T and PD1 CD8+ T cells were analysed by flow cytometric analysis. The expressions of SHIP-1 and SOCS1 were estimated by qRT-PCR. Data are shown from one representative experiment of three independent experiments and presented as a mean ± SD. ***p < 0.001; **p < 0.01.
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