miR-155 deficiency exacerbated CD8⁺ T cell exhaustion by targeting to SHIP-1 and SOCS1. Spleens were collected from each mouse in the WT and miR-155^−/− groups. The percentages of Tregs, IFN-γ CD8⁺ T, TNF-α CD8⁺ T and PD1 CD8⁺ T cells were analysed by flow cytometric analysis. The expressions of SHIP-1 and SOCS1 were estimated by qRT-PCR. Data are shown from one representative experiment of three independent experiments and presented as a mean ± SD. ***p < 0.001; **p < 0.01.