Table 2
Characteristics of parasite clearance according to hemoglobin type.
| HbAA | HbAC | HbAS | HbCC | HbSC | HbSS | |
|---|---|---|---|---|---|---|
| Patients for parasite clearance calculation (n) * | 359 | 20 | 22 | 4 | 6 | 3 |
| Median k (/hour), (IQR) | 0.2 (0.2–0.3) | 0.2 (0.2–0.2) | 0.2 (0.2–0.3) | 0.2 (0.1–0.2) | 0.1 (0.1–0.2) | 0.2 (0.1–0.2) |
| Slope half-life (hour), median (IQR) | 3.1 (2.7–3.6) | 2.9 (2.7–3.2) | 2.6 (2.3–3.6) | 3.4 (3.2–3.6) | 3.8 (3.6–3.9) | 3.2 (2.5–4.3) |
| Patients with slope half-life > 5 h, n (%) | 26 (7.2) | 1 (5.0) | 1 (4.5) | 0 | 0 | 0 |
| PCT in hours, median (IQR) | 24 (24–48) | 24 (24–36) | 24 (24–48) | 48 (42–48) | 48 (48–48) | 24 (24–48) |
| PC50, median (IQR) | 12.1 (9.4–13.3) | 11.9 (8.2–12.4) | 11.7 (9.2–13.9) | 12.8 (12.5–13.1) | 13.7 (13.6–14.0) | 12.5 (9.2–14.4) |
| PC90, median (IQR) | 21.9 (14.7–23.7) | 21.7 (14.5–22.6) | 20.3 (13.3–23.9) | 23.4 (22.9–23.9) | 24.8 (24.2–25.1) | 22.9 (15.0–26.2) |
| PC95, median (IQR) | 24.9 (17.3–27.0) | 24.8 (17.3–25.7) | 23.2 (15.1–27.3) | 26.7 (26.1–27.3) | 28.3 (27.6–28.6) | 26.1 (17.5–29.9) |
| PC99, median (IQR) | 31.0 (23.0–33.6) | 30.7 (23.7–31.9) | 28.8 (19.2–33.9) | 33.1 (32.3–33.8) | 35.0 (34.2–35.4) | 32.3 (23.4–36.9) |
| p-values | HbAA vs. HbAC | HbAA vs. HbAS | HbAA vs. HbCC | HbAA vs. HbSC | HbAA vs. HbSS | |
| Median k (/hour), (IQR) | 0.44 | 0.80 | 0.16 | 0.007 | 0.54 | |
| Slope half-life (hour), median (IQR) | 0.89 | 0.87 | 0.18 | 0.008 | 0.56 | |
| PCT in hours, median (IQR) | 0.13 | 0.49 | 0.05 | 0.02 | 0.82 | |
| PC50, median (IQR) | 0.34 | 0.74 | 0.24 | 0.006 | 0.65 | |
| PC90, median (IQR) | 0.56 | 0.83 | 0.13 | 0.01 | 0.53 | |
| PC95, median (IQR) | 0.55 | 0.82 | 0.12 | 0.02 | 0.14 | |
| PC99, median (IQR) | 0.64 | 0.86 | 0.15 | 0.03 | 0.54 | |
Notes: PC50, 50% parasite clearance rate; PC90, 90% parasite clearance rate; PC95, 95% parasite clearance rate; PC99, 99% parasite clearance rate.
Abbreviations: Hb, hemoglobin; IQR, interquartile range; PCE, parasite clearance estimator; PCT, parasite clearance time; k, parasite clearance rate.
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