Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Notoedres cati mange in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 2

Live Notoedres cati mite counts in cats treated topically once (Day 0) either with mineral oil (placebo control) or NexGard^® Combo, and percentage efficacy of NexGard^® Combo treatment over eight weeks after treatment.

Time point	Live Notoedres cati mite counts				p-value^d	Efficacy^e
	Mineral oil (control)		NexGard^® Combo
	NI/NG^a	AM^b, GM^c, Range	NI/NG	AM, GM, Range
Pre-treatment	7/7	31.6	7/7	24.3	0.5630	NA^f
		22.0		17.0
		5–91		5–67
Day 14	7/7	10.3	0/7	0	<0.001	100%
		9.2		0
		4–21		NA
Day 27/28	6/7	15.3	0/7	0	0.0055	100%
		6.4		0
		0–65		NA
Day 42	6/7	9.4	0/7	0	0.0046	100%
		4.2		0
		0–43		NA
Day 56	6/7	6.9	0/7	0	0.0082	100%
		3.0		0
		0–21		NA

Number of cats positive for mites/Number of cats in group.

Arithmetic mean.

Geometric mean (based on transformation to the natural logarithm of [count + 1]).

p-value = two-sided p-value from the MIXED model of the NexGard^® Combo group and the mineral oil (control) group for mite counts.

Efficacy = 100 × (mean mineral oil [control] − mean NexGard^® Combo/mean mineral oil [control]).

Not applicable.

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