Safety evaluation of a novel topical combination of esafoxolaner, eprinomectin and praziquantel, in reproducing female cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 1

Breeding parameters, statistical analyses, and results.

	Group 1	Group 2	Group 3
Mean gestation length^a: days (SD)	45.7 (3.35)	45.3 (2.21)	45.8 (2.05)
p-value: one-way ANOVA with a treatment effect		0.7771	0.9296
No. of mating pairs	10	9	10
No. of pairs confirmed to have mated	9	7	9
Mating index	0.90	0.78	0.90
p-value vs. Group 1. Fisher’s exact test		0.5820	1.0000
No. of mating pairs	10	9	10
No. of confirmed pregnancies	9	7	9
Conception index	0.90	0.78	0.90
p-value vs. Group 1. Fisher’s exact test		0.5820	1.0000
No. of confirmed pregnancies	9	7	9
No. of females with live kittens	9	7	9
Gestational index	1.00	1.00	1.00
p-value vs. Group 1. Fisher’s exact test		0.5820	1.0000
No. of confirmed pregnancies	9	7	9
No. of females who had an abortion	0	0	0
Abortion rate	0.00	0.00	0.00
p-value vs. Group 1. Fisher’s exact test	Data structure unsupported by Fischer’s exact test
No. of litters	9	7	9
No. of kittens born^b (Min, Max) – Average per litter	34 (2, 6) – 3.8	38 (3, 8) – 5.4	53 (3, 8) – 5.9
p-value: one-way ANOVA with a treatment effect		0.0486	0.0092
No. of kittens born alive^c (Min, Max)	33 (2, 6)	36 (3, 8)	51 (3, 8)
p-value: one-way ANOVA with a treatment effect		0.0821	0.0150
No. of stillborn kittens^d	1	2	2
Proportion	0.03	0.03	0.04
p-value vs. Group 1. Fisher’s exact test		1.0000	1.0000
No. of kittens born with an abnormality^e	1	2	3
Proportion	0.03	0.03	0.06
p-value vs. Group 1. Fisher’s exact test		1.0000	1.0000
No. of litters with at least one abnormality	1	2	2
Proportion	0.11	0.29	0.22
p-value vs. Group 1. Fisher’s exact test		1.0000	1.0000
No. of kittens weaned (56 days after birth)	27	31	50
Weaning index (vs. n° of kittens born alive)	0.82	0.86	0.98
p-value vs. Group 1. Fisher’s exact test		0.7465	0.0134
No. of female kittens born (proportion)	18 (0.53)	19 (0.50)	29 (0.55)
No. of male kittens born (proportion)	16 (0.47)	15 (0.39)	23 (0.43)
Sexing omitted (proportion)	0 (0.0)	4 (0.11)	1 (0.02)
p-value vs. Group 1. Fisher’s exact test		0.1798	0.8950
Mean bodyweight of kittens on Day 7: kg (SD)	0.208 (0.032)	0.179 (0.027)	0.180 (0.025)
p-value: one-way ANOVA with a treatment effect		<0.0001	<0.0001
Mean bodyweight of kittens on Day 56: kg (SD)	0.807 (0.154)	0.686 (0.102)	0.648 (0.104)
p-value: one-way ANOVA with a treatment effect		0.0002	<0.0001
Mean growth of kittens from Day 7 to Day 56: kg	0.599	0.506	0.477
p-value: one-way ANOVA with a treatment effect		0.0030	<0.0001

Group 1: Placebo (mineral oil) at 1.125 mL/kg; Group 2: NexGard^® Combo at 0.375 mL/kg; Group 3: NexGard^® Combo at 1.125 mL/kg.

Gestation length calculated from the day of pregnancy diagnosis to the day of whelping.

Includes kittens born alive, found dead on whelping day and stillborn.

Includes kittens born alive, found dead on whelping day, excludes stillborn.

Stillborn = dead on whelping day, without a single pulmonary inspiratory flow (as determined by lung histology).

Includes stillborn.

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