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Table 1
Relation of genes described with pathogenicity potential found in N. fowleri.
| Pathogenicity-related genes | Gene function | Database accession | OMIC approach |
|---|---|---|---|
| Heat Shock Protein 70 (hsp70) | Cytotoxicity and proliferation related | GenBank AY684788 | Comparative proteomics [75] |
| Actin 1 | Attachment of amoebae to substrates and phagocytosis | GenBank M90311 | Comparative proteomics [75], comparative genomics and transcriptomics [34] |
| Actin 2 | Attachment of amoebae to substrates and phagocytosis | GenBank M90312 | Comparative proteomics [75], comparative genomics and Transcriptomics [34] |
| Formin D | Regulate the formation of actin filaments | Uniprot accession number Q5TJ55 | Comparative proteomics [75], comparative genomics and transcriptomics [34] |
| Severin | Actin-fragmenting and capping proteins | Uniprot accession number P10733 | Comparative proteomics [75], comparative genomics and transcriptomics [34] |
| Villin-1 | Multifunctional actin cytoskeleton regulating protein | Uniprot accession number Q3SZP7 | Comparative proteomics [75], comparative genomics and transcriptomics [34] |
| Myosin II | Phagocytic processes | Uniprot accession number P08799 | Comparative proteomics [75] |
| Membrane protein Mp2CL5 | Contact-dependent pathogenesis | GenBank AY049749 | Comparative proteomics [75] |
| Cyclophilin | Stimulation of pro-inflammatory signaling | GenBank XM_002681214 | Comparative proteomics [75] |
| Apoptosis-linked gene-2-interacting protein X1 (AIP1) | Vesicular trafficking | Uniprot accession number P34552 | Comparative proteomics [75] |
| Naegleriapore A | Vesicular trafficking/destroy target cells | Uniprot accession number Q9BKM2 | Comparative proteomics [75], genomics [47], comparative genomics and transcriptomics [34] |
| Naegleriapore B | Vesicular trafficking/destroy target cells | Uniprot accession number Q9BKM1 | Comparative proteomics [75], comparative genomics and transcriptomics [34] |
| Golgi-localized transmembrane protein HID-1 | Vesicular trafficking/vesicular exocytosis | Uniprot accession number Q8IV36 | Comparative proteomics [75] |
| Ras-related protein Rab-1 | Vesicular trafficking/phagocytosis regulation | Uniprot accession number Q4UB16 | Comparative proteomics [75] |
| Virulence-related protein Nf314 | Protease | Uniprot accession number P42661 | Genomics [47], comparative genomics and transcriptomics [34] |
| Heat Shock Protein 40 (hsp40) domain | Regulator of HSP70 | Uniprot accession number A0A6A5BGT1 | Genomics [47], comparative genomics [35] |
| Serine protease S81 | Lysozyme activity | GenBank AAA96144.1 | Comparative genomics and transcriptomics [34] |
| Rab GTPase Rab32 | Endo-lysosomal trafficking gene | GenBank XP_002683044.1 | Comparative genomics and transcriptomics [34] |
| Retromer component Vps35 | Endo-lysosomal trafficking gene | GenBank NP_060676.2 | Comparative genomics and transcriptomics [34] |
| Nfa1 | Cell–cell adhesion factor | Uniprot accession number Q9NH76 | Comparative genomics and transcriptomics [34] |
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