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Review Article

Table 1

Relation of genes described with pathogenicity potential found in N. fowleri.

Pathogenicity-related genes Gene function Database accession OMIC approach
Heat Shock Protein 70 (hsp70) Cytotoxicity and proliferation related GenBank AY684788 Comparative proteomics [75]
Actin 1 Attachment of amoebae to substrates and phagocytosis GenBank M90311 Comparative proteomics [75], comparative genomics and transcriptomics [34]
Actin 2 Attachment of amoebae to substrates and phagocytosis GenBank M90312 Comparative proteomics [75], comparative genomics and Transcriptomics [34]
Formin D Regulate the formation of actin filaments Uniprot accession number Q5TJ55 Comparative proteomics [75], comparative genomics and transcriptomics [34]
Severin Actin-fragmenting and capping proteins Uniprot accession number P10733 Comparative proteomics [75], comparative genomics and transcriptomics [34]
Villin-1 Multifunctional actin cytoskeleton regulating protein Uniprot accession number Q3SZP7 Comparative proteomics [75], comparative genomics and transcriptomics [34]
Myosin II Phagocytic processes Uniprot accession number P08799 Comparative proteomics [75]
Membrane protein Mp2CL5 Contact-dependent pathogenesis GenBank AY049749 Comparative proteomics [75]
Cyclophilin Stimulation of pro-inflammatory signaling GenBank XM_002681214 Comparative proteomics [75]
Apoptosis-linked gene-2-interacting protein X1 (AIP1) Vesicular trafficking Uniprot accession number P34552 Comparative proteomics [75]
Naegleriapore A Vesicular trafficking/destroy target cells Uniprot accession number Q9BKM2 Comparative proteomics [75], genomics [47], comparative genomics and transcriptomics [34]
Naegleriapore B Vesicular trafficking/destroy target cells Uniprot accession number Q9BKM1 Comparative proteomics [75], comparative genomics and transcriptomics [34]
Golgi-localized transmembrane protein HID-1 Vesicular trafficking/vesicular exocytosis Uniprot accession number Q8IV36 Comparative proteomics [75]
Ras-related protein Rab-1 Vesicular trafficking/phagocytosis regulation Uniprot accession number Q4UB16 Comparative proteomics [75]
Virulence-related protein Nf314 Protease Uniprot accession number P42661 Genomics [47], comparative genomics and transcriptomics [34]
Heat Shock Protein 40 (hsp40) domain Regulator of HSP70 Uniprot accession number A0A6A5BGT1 Genomics [47], comparative genomics [35]
Serine protease S81 Lysozyme activity GenBank AAA96144.1 Comparative genomics and transcriptomics [34]
Rab GTPase Rab32 Endo-lysosomal trafficking gene GenBank XP_002683044.1 Comparative genomics and transcriptomics [34]
Retromer component Vps35 Endo-lysosomal trafficking gene GenBank NP_060676.2 Comparative genomics and transcriptomics [34]
Nfa1 Cell–cell adhesion factor Uniprot accession number Q9NH76 Comparative genomics and transcriptomics [34]

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