Heartworm count per treatment group and efficacy of NexGard® Combo against D. immitis in cats.
|Treatment groupsa||n||Total D. immitis counts in individual cats at necropsyb||D. immitis counts geometric mean||Efficacy||P-value||Total live D. immitis counts by sex/Total live count ranges per cat by sex|
|Study 1||Control (Placebo)||10||0, 1, 2, 5, 8, 8, 8, 14, 16, 16||5.1||NA||NA||32 m & 43 f/2–9 m & 1–11 f|
|NexGard® Combo||10||0 in each of the 10 cats||0.0||100%||<0.0001||0/0|
|Study 2||Control (Placebo)||10||0, 0, 0, 1, 1, 1, 3, 6, 6, 7||1.6||NA||NA||15 m & 10 f/1–4 m & 1–4 f|
|NexGard® Combo||10||0 in each of the 10 cats||0.0||100%||0.0024||0/0|
m = male; f = female; NA = not applicable.
Placebo group treated once on Day 0 with 0.12 mL/kg of mineral oil and NexGard® Combo Group treated once on Day 0 with 0.12 mL/kg of the novel formulation delivering 1.44 mg/kg esafoxolaner, 0.48 mg/kg eprinomectin, and 10.0 mg/kg praziquantel.
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