Table 2
Summary of the pharamacokinetic parameters (mean ± SD) of esafoxolaner, eprinomectin and praziquantel in NexGard® Combo following a single topical application at the minimum recommended dose, of eprinomectin and praziquantel in Broadline®, and of esafoxolaner alone administered topically or intravenously.
| Analyte | Group1 | T1/2 | Tmax | Cmax | AUC0−Tlast | AUC0−inf | Cl | Vss |
|---|---|---|---|---|---|---|---|---|
| (day) | (day) | (ng/mL) | (day × ng/mL) | (day × ng/mL) | (mL/day/kg) | (mL/kg) | ||
| Esafoxolaner –Topical | 1 | 21.7 ± 2.8 | 7.13 ± 3.1 | 130 ± 36 | 4411 ± 1525 | 4972 ± 1711 | NA | NA |
| 2 | 20.8 ± 6.4 | 3.75 ± 3.1 | 218 ± 68 | 6368 ± 1665 | 7181 ± 2250 | NA | NA | |
| p-value2 | 0.713 | 0.019 | 0.0305 | 0.0792 | 0.0923 | NA | NA | |
| Eprinomectin –Topical | 1 | 5.42 ± 2.7 | 1.46 ± 0.47 | 23.6 ± 11 | 156 ± 94 | 159 ± 94 | NA | NA |
| 3 | 5.63 ± 1.6 | 1.71 ± 0.97 | 27.1 ± 16 | 175 ± 67 | 179 ± 69 | NA | NA | |
| p-value2 | 0.806 | 0.476 | 0.6 | 0.656 | 0.642 | NA | NA | |
| Praziquantel – Topical | 1 | 4.30 ± 1.9 | 0.292 ± 0.08 | 107 ± 59 | 123 ± 25 | 132 ± 23 | NA | NA |
| 3 | 3.50 ± 2.2 | 0.313 ± 0.06 | 118 ± 88 | 185 ± 93 | 173 ± 89 | NA | NA | |
| p-values2 | 0.462 | 0.351 | 0.797 | 0.0897 | 0.187 | NA | NA | |
| Esafoxolaner –Intravenous | 4 | 21.0 ± 4.2 | NA | NA | 9586 ± 1985 | 10,542 ± 2029 | 141 ± 29.5 | 4016 ± 1190 |
| p-value2 vs. 1 | 0.657 | NA | NA | NA | NA | NA | NA | |
| p-value2 vs. 2 | 0.484 | NA | NA | NA | NA | NA | NA |
T1/2 = plasma half-life; Tmax = time from dosing to the maximum concentration; Cmax = peak drug plasma concentration; AUC = area under the concentration versus time curve: 0−Tlast = from the time of dosing to the time to the last quantifiable concentration, 0−inf = from the time of dosing to infinity (by extrapolation); Cl = systemic clearance; Vss = volume of distribution at steady-state.
Group 1: NexGard Combo – Topical; esafoxolaner 1.44 mg/kg, eprinomectin 0.5 mg/kg, praziquantel 10.0 mg/kg.
Group 2: Esafoxolaner alone – Topical; esafoxolaner 1.44 mg/kg.
Group 3: Broadline® – Topical; fipronil 10.0 mg/kg, (S)-methoprene 12.0 mg/kg, eprinomectin 0.5 mg/kg, praziquantel 10.0 mg/kg.
Group 4: Esafoxolaner – IV; esafoxolaner 1.44 mg/kg.
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.