Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 1

Study designs.

Study/Group	n⁶	Dosage (mL/kg)	Treatment Day(s)	Blood collection days (minutes, hours after treatment)
Study #1 – Pharmacokinetics and non-interference
NexGard^® Combo – Topical¹	8	0.12	0	0 (4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 29, 42, 56, 70
Esafoxolaner – Topical²	8	0.12	0	0 (4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 29, 42, 56, 70
Broadline^® – Topical³	8	0.12	0	0 (4 h, 8 h), 1(24 h, 32 h), 2, 4, 7, 14, 21, 29, 42, 56, 70
Esafoxolaner – Intravenous²	6	0.12	0	0 (15 min, 30 min, 2 h, 4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 29, 42, 56, 70
Study #2 – Dose proportionality and multiple-dose kinetics
NexGard^® Combo – Topical– 0.5×⁴	8	0.06	0	0 (2 h, 4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 28, 42, 56,70, 84 and 91
NexGard^® Combo – Topical– 1× ¹	8	0.12	0	0 (2 h, 4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 28, 42, 56,70, 84 and 91
NexGard^® Combo – Topical – 2× ⁵	8	0.24	0	0 (2 h, 4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 28, 42, 56,70, 84 and 91
NexGard^® Combo – Topical– 1×¹	8	0.12	0, 28, 56, 84, 112	0 (2 h, 4 h, 8 h), 1 (24 h, 32 h), 2, 4, 7, 14, 21, 28^, 56^, 84^, 112 (0 h^, 2 h, 4 h, 8 h), 113 (24 h, 32 h), 114 (48 h), 116, 119, 126, 133, 140, 154 and 168

Blood sampling before treatment.

Esafoxolaner 1.44 mg/kg, praziquantel 10.0 mg/kg, eprinomectin 0.5 mg/kg.

Esafoxolaner alone 1.44 mg/kg.

Fipronil 10.0 mg/kg, (S)-methoprene 12.0 mg/kg, praziquantel 10.0 mg/kg, eprinomectin 0.5 mg/kg.

⁴

Esafoxolaner 0.72 mg/kg, praziquantel 5.0 mg/kg, eprinomectin 0.25 mg/kg.

⁵

Esafoxolaner 2.88 mg/kg, praziquantel 20.0 mg/kg, eprinomectin 1.0 mg/kg.

⁶

n = number of cats per group (equal number of males and females).

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