Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Echinococcus multilocularis infections in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 2

Efficacy of the novel formulation against induced E. multilocularis infections in cats.

	E. multilocularis counts				Efficacy^c (%)	p-value^d
	Placebo group		Novel formulation group
	NI/NG^a	GM^b (range)	NI/NG^a	GM^b (range)
Study #1	5/10	8.9 (0–1025)	0/10	0.0 (0)	100.0	0.0123
Study #2	8/10	28.8 (0–345)	0/10	0.0 (0)	100.0	0.0002

NI/NG: number of cats infected/number of cats in the group.

GM = geometric mean.

Percent efficacy = ([C – T]/C) × 100, where T and C were geometric means of the placebo and the novel formulation groups, respectively.

p-value = two-sided probability value from analysis of variance on log-counts of placebo and novel formulation groups.

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