Study contexts and designs.
|Studies||Lab #1||Lab #2||Field|
|Model||Induced infestation||Natural infestation||Natural infestation|
|Location/date||South Africa/Dec 2015 – March 2016||Michigan, USA/Dec 2018 – Jan 2019||Europe/Oct 2018 – Apr 2019|
|O. cynotis strain origin||South Africa||USA||Hungary and Greece|
|Variable used for randomization||Bodyweight||Pre-treatment otoscopic live mite count||Order of presentation|
|Inlusion criteria||Both ear canals positive for mites||Both ear canals positive for mites||At least 1 motile ear mite in 1 ear canal|
|Number of treated/control cats||8/8||10/10||32/33 sentinels*, 54/61 total*|
|Treatment dose||Minimum dose of 0.12 mL/kg||Minimum dose of 0.12 mL/kg||Commercial dose|
|Main variable of efficacy||Live O. cynotis counts collected in ear canals, Day 28||Live O. cynotis counts collected in ear canals, Day 32||Live O. cynotis counts collected in ear canals of sentinel animals, Day 30 (±3)|
|Secondary efficacy evaluations||Otoscopic assessment (scoring of debris/cerumen and live mites), Days −7, 7, 14, 21, 28||None||Otoscopic assessment (scoring of pruritus and quality/quantity of cerumen), Day 0, Day 30 (±3)|
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