Table 1
Study contexts and designs.
| Studies | Lab #1 | Lab #2 | Field |
|---|---|---|---|
| Model | Induced infestation | Natural infestation | Natural infestation |
| Location/date | South Africa/Dec 2015 – March 2016 | Michigan, USA/Dec 2018 – Jan 2019 | Europe/Oct 2018 – Apr 2019 |
| O. cynotis strain origin | South Africa | USA | Hungary and Greece |
| Variable used for randomization | Bodyweight | Pre-treatment otoscopic live mite count | Order of presentation |
| Inlusion criteria | Both ear canals positive for mites | Both ear canals positive for mites | At least 1 motile ear mite in 1 ear canal |
| Number of treated/control cats | 8/8 | 10/10 | 32/33 sentinels*, 54/61 total* |
| Treatment dose | Minimum dose of 0.12 mL/kg | Minimum dose of 0.12 mL/kg | Commercial dose |
| Main variable of efficacy | Live O. cynotis counts collected in ear canals, Day 28 | Live O. cynotis counts collected in ear canals, Day 32 | Live O. cynotis counts collected in ear canals of sentinel animals, Day 30 (±3) |
| Secondary efficacy evaluations | Otoscopic assessment (scoring of debris/cerumen and live mites), Days −7, 7, 14, 21, 28 | None | Otoscopic assessment (scoring of pruritus and quality/quantity of cerumen), Day 0, Day 30 (±3) |
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.