Table 1

Study contexts and designs.

Studies Lab #1 Lab #2 Field
Model Induced infestation Natural infestation Natural infestation
Location/date South Africa/Dec 2015 – March 2016 Michigan, USA/Dec 2018 – Jan 2019 Europe/Oct 2018 – Apr 2019
O. cynotis strain origin South Africa USA Hungary and Greece
Variable used for randomization Bodyweight Pre-treatment otoscopic live mite count Order of presentation
Inlusion criteria Both ear canals positive for mites Both ear canals positive for mites At least 1 motile ear mite in 1 ear canal
Number of treated/control cats 8/8 10/10 32/33 sentinels*, 54/61 total*
Treatment dose Minimum dose of 0.12 mL/kg Minimum dose of 0.12 mL/kg Commercial dose
Main variable of efficacy Live O. cynotis counts collected in ear canals, Day 28 Live O. cynotis counts collected in ear canals, Day 32 Live O. cynotis counts collected in ear canals of sentinel animals, Day 30 (±3)
Secondary efficacy evaluations Otoscopic assessment (scoring of debris/cerumen and live mites), Days −7, 7, 14, 21, 28 None Otoscopic assessment (scoring of pruritus and quality/quantity of cerumen), Day 0, Day 30 (±3)

In the field trial, all cats in a household (total) were treated, one cat per household (sentinel) was evaluated for efficacy and safety, all other cats for safety.

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