Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against adult cat flea Ctenocephalides felis and flea egg production in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 5

Ctenocephalides felis egg production reduction and larval hatching inhibition.

	Flea egg production					Larval hatching proportion from collected eggs
	Period of egg collection	GM¹ control group	GM¹ treated group	% reduction²	p-value	Period of incubation	% control group (N)	% treated group (N)	p-value
Study #2	Days 0–1	68.1	16.4	75.9	0.0128	Days 1–4	47 (10)	17.0 (9)	0.0058
n = 10	Days 7–8	35.6	0.1	99.8	<0.0001	Days 8–11	50 (9)	NA (1)	–^*
	Days 14–15	28.2	0.0	100.0	<0.0001	Days 15–18	41 (10)	– (0)	–
	Days 21–22	38.7	0.0	100.0	<0.0001	Days 22–25	55 (9)	– (0)	–
	Days 30–31	36.5	0.0	100.0	<0.0001	Days 31–34	34 (10)	– (0)	–
Study #3	Days 1–3	138.6	9.5	93.2	0.0019	Days 3–6	68 (8)	26 (7)	0.0001
n = 8	Days 8–10	102.6	0.0	100.0	<0.0001	Days 10–13	84 (8)	– (0)	–
	Days 15–17	171.6	0.3	99.8	<0.0001	Days 17–20	73 (8)	NA (1)	–^*
	Days 22–24	130.4	0.0	100.0	<0.0001	Days 24–27	68 (8)	– (0)	–
	Days 29–31	260.3	0.1	100.0	<0.0001	Days 31–34	72 (8)	NA (1)	–^*

Statistical analysis not performed as not meaningful because eggs produced on only one cat.

GM = Geometric mean; n = number of cats per group; N = number of cats from which egg(s) were collected and incubated.

The percent reduction was calculated as [(C − T)/C] × 100, where C was the geometric mean of the egg counts among the placebo control cats, and T was the geometric mean among the Nexgard^® Combo-treated cats.

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