Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against adult cat flea Ctenocephalides felis and flea egg production in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 2

Study designs.

	Treatment¹	Infestations (~100 unfed adult C. felis)	Flea counts (comb count)	Egg collection²	Egg incubation³
Study #1	Day 0	Days −1, 6, 13, 20, 27, 34, 41, 48, 55	Days 1, 7, 14, 21, 28, 35, 42, 49, 56	NA	NA
Study #2	Day 0	Days −1, 7, 14, 21, 30	Days 1, 8, 15, 22, 31	Days 0–1, 7–8, 14–15, 21–22, 30–31	Days 0–4, 7–11, 14–18, 21–25, 30–34
Study #3	Day 0	Days 1, 8, 15, 22, 29	Days 3, 10, 17, 24, 31 (removal only)	Days 1–3, 8–10, 15–17, 22–24, 29–31	Days 1–6, 8–13, 15–20, 22–27, 29–34
Study #4	Day 0	Days −1, 6, 13, 20, 30, 37	Days 1, 7, 14, 21, 31, 38	NA	NA

Cat were treated once topically with Nexgard^® Combo at the minimum recommended dose (the control group was treated with a placebo).

Cats were placed in individual enclosures for egg collection; eggs were collected daily and incubated on the day of collection.

Larval hatching assessment performed on the last day of incubation.

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