Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Ixodes ricinus and Ixodes scapularis in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 4

Ixodes scapularis studies: mean live tick counts per group and efficacy results

Study	n	Arithmetic means (AM) of live ticks and % efficacy¹ on indicated days
I. scapularis #1			Day 2	Day 9	Day 16	Day 23	Day 32
Control group²	8	AM	26.5	27.9	30.4	32.1	32.5
Treated group³	8	AM	1.3	0.2	0.0	0.4	0.0
		% efficacy⁴	95.1	99.3	100.0	98.8	100.0
I. scapularis #2			Day 2	Day 9	Day 16	Day 22	Day 32
Control group²	10	AM	24.5	26.5	27.2	24.4	22.2
Treated group³	10	AM	0.3	0.0	0.0	0.1	0.4
		% efficacy⁴	98.8	100.0	100.0	99.6	98.2

Note: p-values⁵ for comparison of the untreated and treated groups = <0.0001 at all time-points.

n = number of cats per group.

The I. scapularis counts were analyzed using SAS Version 9.4. The logarithm of the (count + 1) was analyzed at each study day separately using the MIXED procedure with treatment group used as a fixed effect and blocks used as a random effect.

Control group = Mineral oil administered topically once on Day 0 at 0.12 mL/kg

Treated group = Novel formulation administered topically once on Day 0 at 0.12 mL/kg, providing 1.4 mg/kg esafoxolaner, 10.0 mg/kg praziquantel and 0.5 mg/kg eprinomectin

⁴

Percent efficacy = [(C – T)/C] × 100, where C and T are the arithmetic means of the control and treated groups, respectively.

⁵

Two-sample probability value comparing the population means of the treated group vs. the control group.

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