Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Ixodes ricinus and Ixodes scapularis in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 3

Ixodes ricinus studies: mean live tick counts per group and efficacy results.

Study	n	Arithmetic means (AM) of live ticks and % efficacy¹ on indicated days
I. ricinus #1			Day 2	Day 9	Day 16	Day 23	Day 30	Day 37	Day 44
Control group²	6	AM	20.5	20.8	19.0	24.3	31.2	30.8	–
Treated group⁴	6	AM	1.8	0.0	0.0	0.0	0.3	2.7	–
		% efficacy⁵	91.1	100.0	100.0	100.0	98.9	91.4	–
I. ricinus #2			Day 2	Day 9	Day 16	Day 23	Day 30	Day 37	Day 44
Control group³	8	AM	23.1	–	–	27.0	29.5	26.6	14.4
Treated group⁴	8	AM	1.9	–	–	0.4	0.0	0.0	0.9
		% efficacy⁵	91.9	–	–	98.6	100.0	100.0	93.9
I. ricinus #3			Day 2	Day 10	Day 16	Day 22	Day 30	Day 37	–
Control group³	10	AM	21.0	17.8	18.1	23.9	19.1	21	–
Treated group⁴	10	AM	0.0	0.0	0.0	0.0	0.2	0.0	–
		% efficacy⁵	100.0	100.0	100.0	100.0	99.0	100.0	–

Note: p-values⁶ for comparison of the untreated and treated groups = <0.0001 at all time-points.

n = number of cats per group.

The I. ricinus counts were analyzed using SAS Version 9.4. The logarithm of the (count + 1) was analyzed at each study day separately using the MIXED procedure with treatment group used as a fixed effect and blocks used as a random effect.

Control group = Mineral sham dosed.

Control group = Mineral oil administered topically once on Day 0 at 0.12 mL/kg.

⁴

Treated group = Novel formulation administered topically once on Day 0 at 0.12 mL/kg, providing 1.4 mg/kg esafoxolaner, 10.0 mg/kg praziquantel and 0.5 mg/kg eprinomectin.

⁵

Percent efficacy = [(C – T)/C] × 100, where C and T are the arithmetic means of the control and treated groups, respectively.

⁶

Two-sample probability value comparing the population means of the treated group vs. the control group.

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