Efficacy of a novel topical combination of esafoxolaner, eprinomectin and praziquantel against Ixodes ricinus and Ixodes scapularis in cats

Special Issue – NexGard^® Combo (esafoxolaner, eprinomectin, praziquantel): A new endectocide spot-on formulation for cats. Invited Editor: Frédéric Beugnet

Open Access

Table 2

Tick colonies (origin, number and sex), infestations and tick counts for efficacy evaluations by study.

Study #	Ixodes strain origin	Number of ticks at infestation	Infestation timepoints	Efficacy timepoints (48 h after treatment or infestation)
I. ricinus #1	North and southwest Germany, EU	40 females¹	Days −2, 7, 14, 21, 28, 35	Days 2, 9, 16, 23, 30, 37
I. ricinus #2	Berlin, Germany, EU	40 females² (25 at Day 42)	Days −2, 21, 28, 35, 42	Days 2, 23, 30, 37, 44
I. ricinus #3	North and southwest Germany, EU	50 females²	Days −2, 8, 14, 20, 28, 35	Days 2, 10, 16, 22, 30, 37
I. scapularis #1	Oklahoma, USA	50 (males and females)	Days −2, 7, 14, 21, 30	Days 2, 9, 16, 23, 32
I. scapularis #2	South Carolina, USA¹	50 (males and females)	Days −2, 7, 14, 21, 30	Days 2, 9, 16, 23, 32

Ticks wild caught from the field.

And an undefined number of males.

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