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All issues Volume 28 (2021) Parasite, 28 (2021) 24 Full HTML

Table 1

Rhipicephalus sanguineus, mean live tick counts per group and efficacy results.

n 5 Day 2 Day 9 Day 16 Day 23 Day 32 Day 39 Day 46 Day 55 Day 60
Control group1 AM3 10 15.7 19.5 21.9 18.5 19.2 15.7 17.9 16.9 14.2
Treated group2 AM3 10 1.6 0.0 0.0 0.0 0.2 0.5 0.7 2.0 5.3
% Efficacy4 89.8 100.0 100.0 100.0 99.0 96.8 96.1 88.2 62.7
p-value <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 0.0191
1

The Control (CP) group was treated topically once on Day 0 with 0.12 mL/kg Technical oil.

2

The Treated (IVP) group was treated topically once on Day 0 with 0.12 mL/kg of the novel formulation of (S)afoxolaner, eprinomectin and praziquantel.

3

Percent efficacy = [(C − T)/C] × 100, where T and C are arithmetic means (AM) of the IVP group and the CP group, respectively.

4

p-value = two-sided p-value from the MIXED model of the IVP group and the CP group.

5

n = number of cats per group: one cat was removed on Day 50 because deemed unsuitable to remain in the study for excessive tick bite wounds, consequently n = 9 in the control group on Days 55 and 60.

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