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Table 3

Non-O. ochengi (O. gutturosa and O. dukei) MFD per gram of skin in each animal and each treatment group at D0, M6, M12, and M24. Post-treatment-positive results are shown in bold.

Groupa ID D0
M6
M12
M24
W No. Ogd MFD Ogd W No. Ogd MFD Ogd W No. Ogd MFD Ogd W No. Ogd MFD Ogd
A 4 0.73 2 2.7 0.18 0 0 1.90 0 0 0.92 0 0
A 9 0.34 90 264.7 0.31 0 0 1.00 0 0 0.70 0 0
A 28 0.25 20 80.0 0.24 0 0 1.10 0 0 0.87 0 0
A 294 0.22 216 981.8 0.99 0 0 1.30 0 0 1.47 0 0
Meanb 332.3 0 0 0
B 3 0.30 11 36.7 0.44 0 0 1.10 0 0 0.32 0 0
B 92 0.18 92 511.1 0.30 0 0 1.10 0 0 0.86 0 0
B 147 0.62 40 64.5 0.47 0 0 0.30 0 0 1.36 0 0
B 255 0.44 137 311.4 0.16 0 0 1.50 0 0 0.13 0 0
Meanb 230.9 0 0 0
C 254 0.45 9 20.0 0.32 21 65.6 0.90 0 0 0.52 59 113.5
C 256 0.37 5 14.7 0.50 7 14.0 0.40 27 67.5 0.52 0 0
Meanb 17.3 39.8 33.7 56.7

Abbreviations: ID = animal identity number; W = weight of skin specimen (in grams); No. Ogd = total number of microfilariae of Onchocerca gutturosa or O. dukei having emerged from the skin specimen; MFD Ogd = O. gutturosa + O. dukei microfilarial density per gram of skin.

a

A = 500 mg IVM; B = 1000 mg IVM; C = Control (vehicle only).

b

Arithmetic mean of the individual Onchocerca ochengi microfilarial densities in the group.

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