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Table 2

Onchocerca ochengi MFD per gram of skin in each animal and each treatment group at D0, M6, M12, and M24. Post-treatment-positive results are shown in bold.

Groupa ID D0
M6
M12
M24
W No. Oo MFD Oo W No. Oo MFD Oo W No. Oo MFD Oo W No. Oo MFD Oo
A 4 0.73 15 20.5 0.18 0 0 1.90 0 0 0.92 0 0
A 9 0.34 177 520.6 0.31 0 0 1.00 0 0 0.70 7 10.0
A 28 0.25 334 1336.0 0.24 0 0 1.10 1 0.9 0.87 0 0
A 294 0.22 2 9.1 0.99 0 0 1.30 0 0 1.47 0 0
Meanb 471.6 0 0.2 2.5
B 3 0.30 0 0 0.44 0 0 1.10 0 0 0.32 0 0
B 92 0.18 6 33.3 0.30 0 0 1.10 0 0 0.86 0 0
B 147 0.62 287 462.9 0.47 0 0 0.30 0 0 1.36 0 0
B 255 0.44 173 393.2 0.16 0 0 1.50 0 0 0.13 0 0
Meanb 296.5 0 0 0
C 254 0.45 207 460.0 0.32 120 375.0 0.90 1110 1233.3 0.52 120 230.8
C 256 0.37 25 67.6 0.50 137 274.0 0.40 187 467.5 0.52 1335 2567.3
Meanb 263.8 324.5 850.4 1399.0

Abbreviations: ID = animal identity number; W = weight of skin specimen (in grams); No. Oo = total number of microfilariae of Onchocerca ochengi having emerged from the skin specimen; MFD Oo = O. ochengi microfilarial density per gram of skin.

a

A = 500 mg IVM; B = 1000 mg IVM; C = Control (vehicle only).

b

Arithmetic mean of the individual Onchocerca ochengi microfilarial densities in the group (in group B, the mean was calculated after excluding animal #3, which did not present O. ochengi microfilariae before treatment).

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