Table 2
Prior characterization of P-type transport ATPases in the Trypanosomatidae.
| Protein | Size (aa) | Prior Homologues [Citation] | Size (aa) | Percent identity | Accession | Localization (stage) | Expression (stage) | mRNA |
|---|---|---|---|---|---|---|---|---|
| P2A, Ca++ transport (SERCA) | ||||||||
| LD2 | 1023 | LDSERCA [154] | 1023 | 94 | Q5S054 | |||
| LMx2 | 1013 | Lmaa1 [87, 137] | 1031 | 87 | O09489 | ER (P, A) | P, A ↑ | 3.5 kb |
| TB2 | 1011 | TBA1 [114, 133] | 1011 | 99 | P35315 | ER (Pc, B) | Pc, B | 4.3 kb |
| TC2s | 1006 | TcSCA1 [55] | 1006 | 97 | O96608 | ER (E, T, A) | E, T, A | 5.0 kb |
| P2B, Ca++ transport (PMCA) | ||||||||
| TB3 | 1080 | TbPMC2 (TbA2) [90] | 1080 | 100 | Q8I919 | PM (Pc) | Pc, B ↑ | 4.43 kb |
| TB4 | 1106 | TbPMC1 (TbA1) [90] | 1106 | 99 | Q8I920 | AC (Pc) | Pc, B ↑ | 4.12 kb |
| TB4b | 1102 | TBCA2 [154] | 340 (p) | 96 | Q9XZJ8 | |||
| TC3s/3p | 1101/1103 | Tca1 [88] | 1100 | 90 | O60948 | AC, PM (E, T, A) | E, T ↑, A ↑↑ | 4.3 kb |
| TCCA2 [154] | 341 (p) | 98 | Q86QH6 | |||||
| P2D, Na+ transport | ||||||||
| LD7 | 1109 | LDCA1 [154] | 1047 | 92 | O61136 | P, A | >7.5 kb | |
| TB7 | 1041 | TBCA1 [154] | 340 (p) | 100 | Q9XZJ9 | PM (Pc, B) | Pc, B ↑ | 5.0 kb |
| TC7s/7p | 1039 | TcENA [66] | 1039 | 100 | Q76DT8 | PM (E, T, A) | E ↑, T ↑, A | 4.5 kb |
| TCNA1 [154] | 340 (p) | 97 | Q86QH8 | |||||
| P3A, H+ transport | ||||||||
| LD8 | 974 | LDH1A [98, 99] | 974 | 97 | P11718 | P, A ↓ | 5.20 kb | |
| LD9 | 974 | LDH1B [98, 99] | 974 | 95 | P12522 | P, A | 5.75 kb | |
| TB8 | 920 | TbHA3 [91] | 920 | 100 | Q6WZI6 | PM (Pc, B) | Pc ↑, B | 3.58 kb |
| TbHA2 [91] | 905 | 92 | Q7Z1X2 | PM (Pc, B) | Pc ↑, B | 3.59 kb | ||
| TBH1 [154] | 257 (p) | 100 | Q9XZJ7 | |||||
| TB9 | 912 | TbHA1 [91] | 912 | 100 | Q86DE0 | PM (Pc, B) | Pc ↑, B | 3.56 kb |
| TC10s | 898 | TCH1 [101] | 599 (p) | 61 | O00931 | |||
| TCH3 [101] | 925 | 64 | O15637 | E ↑, T | 3.8 kb | |||
| TcHA1 [89, 170] | 875 | 65 | Q8T7V7 | PM, R (E, T, A) | E ↑, T, A | 3.86 kb | ||
| TcHA2 [89, 170] | 917 | 64 | Q8T7V6 | R (E, T, A) | E, T ↑, A | 5.35 kb | ||
| P4, aminophospholipid translocation | ||||||||
| LD13 | 1157 | LDAPLT1 [154] | 1156 | 89 | O61137 | |||
| LD15 | 1097 | LdMT [123] | 1097 | 93 | Q6VXY9 | PM (P) | ||
| TC15s/15p | 1099 | TCAPLT2 [154] | 387 (p) | 99 | Q86QH7 | |||
Notes. aa, amino acids; kb, kilobase pairs; PMCA, plasma membrane calcium ATPase; SERCA, sarcoplasmic-endoplasmic reticulum calcium ATPase; (p), partial sequence; AC, acidocalcisome membrane; ER, endoplasmic reticulum membrane; PM, plasma membrane; R, reservosome; A, amastigote stage; B, bloodstream stage trypomastigote; E, epimastigote stage trypomastigote; Pc, procyclic stage trypomastigote; P, promastigote stage; ↑, upregulated; ↓, downregulated. Accession numbers are from the UniProtKB database (http://www.uniprot.org).
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